The association of urinary organophosphate ester metabolites and self-reported personal care and household product use among pregnant women in Puerto Rico

Ingle, Mary E.; Watkins, Deborah J.; Rosario, Zaira; Vega, Carmen M. Vélez; Huerta-Montañez, Gredia; Calafat, Antònia M.; Ospina, María; Cordero, José F.; Alshawabkeh, Akram N.; Meeker, John D.

doi:10.1016/j.envres.2019.108756

Cited by 29 publications

(36 citation statements)

References 50 publications

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“…Such chemicals include organophosphate esters (OPE), which may be used in consumer products as either flame retardants or plasticizers, as well as phthalates and phenols. These chemicals, or their metabolites, are commonly detected in the urine of pregnant women [ 9 – 11 ]. Previous studies have linked the use of consumer products, such as cosmetics or household cleaners, to higher exposure to OPEs [ 9 , 12 ], phthalates [ 11 , 13 ], and phenols [ 10 ] in pregnant women.…”

Section: Introductionmentioning

confidence: 99%

“…These chemicals, or their metabolites, are commonly detected in the urine of pregnant women [ 9 – 11 ]. Previous studies have linked the use of consumer products, such as cosmetics or household cleaners, to higher exposure to OPEs [ 9 , 12 ], phthalates [ 11 , 13 ], and phenols [ 10 ] in pregnant women. Exposures from consumer products likely occur through dermal or inhalation pathways and represent a substantial proportion of exposure to many of these chemicals [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

et al. 2021

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Background While fetal growth is a tightly regulated process, it is sensitive to environmental exposures that occur during pregnancy. Many commonly used consumer products contain chemicals that can disturb processes underlying fetal growth. However, mixtures of these chemicals have been minimally examined. We investigated associations between prenatal exposure to 33 consumer product chemicals (nine organophosphate ester flame retardant [OPE] metabolites, 12 phthalate metabolites, and 12 phenols) and the odds of small- or large-for-gestational age (SGA and LGA) births. Methods This case-control study was comprised of SGA (N = 31), LGA (N = 28), and appropriate for gestational age control (N = 31) births selected from the larger LIFECODES cohort. Biomarkers of exposure to consumer product chemicals were quantified in maternal urine collected from up to three study visits during pregnancy. In a single-pollutant approach, odds ratios (OR) and 95% confidence intervals (CI) of SGA and LGA associated with an interquartile range (IQR)-increase in exposure biomarkers were estimated using multinomial logistic regression. In a multi-pollutant approach, quantile g-computation was used to jointly estimate the OR (95% CI) of SGA and LGA per simultaneous one quartile-change in all biomarkers belonging to each chemical class. Results Among the 33 biomarkers analyzed, 20 were detected in at least 50% of the participants. After adjusting for potential confounders, we observed reduced odds of LGA in association with higher urinary concentrations of several exposure biomarkers. For example, an IQR-increase in the OPE metabolite, diphenyl phosphate, was associated with lower odds of LGA (OR: 0.40 [95% CI: 0.18, 0.87]). Using quantile g-computation, we estimated lower odds of an LGA birth for higher OPE metabolite concentrations (OR: 0.49 [95% CI: 0.27, 0.89]) and phthalate metabolite concentrations (OR: 0.23 [95% CI: 0.07, 0.73]). Associations between consumer product chemicals and SGA were largely null. Conclusions Joint exposure to OPEs and phthalates was associated with lower odds of delivering LGA. Associations with LGA could indicate a specific impact of these exposures on the high end of the birth weight spectrum. Future work to understand this nuance in the associations between consumer product chemical mixtures and fetal growth is warranted.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Such chemicals include organophosphate esters (OPE), which may be used in consumer products as either ame retardants or plasticizers, as well as phthalates and phenols. These chemicals, or their metabolites, are commonly detected in the urine of pregnant women (9)(10)(11). Previous studies have linked the use of consumer products, such as cosmetics or household cleaners, to higher exposure to OPEs (9,12), phthalates (11,13), and phenols (10) in pregnant women.…”

Section: Introductionmentioning

confidence: 99%

“…These chemicals, or their metabolites, are commonly detected in the urine of pregnant women (9)(10)(11). Previous studies have linked the use of consumer products, such as cosmetics or household cleaners, to higher exposure to OPEs (9,12), phthalates (11,13), and phenols (10) in pregnant women. Exposures from consumer products likely occur through dermal or inhalation pathways and represent a substantial proportion of exposure to many of these chemicals (14,15).…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

Bommarito

Welch

Keil

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: While fetal growth is a tightly regulated process, it is sensitive to environmental exposures that occur during pregnancy. Many commonly used consumer products contain chemicals that can disturb processes underlying fetal growth. However, mixtures of these chemicals have been minimally examined. We investigated associations between prenatal exposure to 33 consumer product chemicals (nine organophosphate ester flame retardant [OPE] metabolites, 12 phthalate metabolites, and 12 phenols) and the odds of small- or large-for-gestational age (SGA and LGA) births.Methods: This case-control study was comprised of SGA (N = 31), LGA (N = 28), and appropriate for gestational age control (N = 31) births selected from the larger LIFECODES cohort. Biomarkers of exposure to consumer product chemicals were quantified in maternal urine collected from up to three study visits during pregnancy. In a single-pollutant approach, odds ratios (OR) and 95% confidence intervals (CI) of SGA and LGA associated with an interquartile range (IQR)-increase in exposure biomarkers were estimated using multinomial logistic regression. In a multi-pollutant approach, quantile g-computation was used to jointly estimate the OR (95% CI) of SGA and LGA per simultaneous one quartile-change in all biomarkers belonging to each chemical class. Results: Among the 33 biomarkers analyzed, 20 were detected in at least 50% of the participants. After adjusting for potential confounders, we observed reduced odds of LGA in association with higher urinary concentrations of several exposure biomarkers. For example, an IQR-increase in the OPE metabolite, diphenyl phosphate, was associated with lower odds of LGA births (OR: 0.40 [95% CI: 0.18, 0.87]). Using quantile g-computation, we estimated lower odds of an LGA birth for higher OPE metabolite concentrations (OR: 0.49 [95% CI: 0.27, 0.89]) and phthalate metabolite concentrations (OR: 0.23 [95% CI: 0.07, 0.73]). Associations between consumer product chemicals and SGA were largely null. Conclusions: Joint exposure to OPEs and phthalates was associated with lower odds of delivering LGA. Associations with LGA could indicate a specific impact of these exposures on the high end of the birth weight spectrum. Future work to understand this nuance in the associations between consumer product chemical mixtures and fetal growth is warranted.

show abstract

“…Such chemicals include organophosphate esters (OPE), which may be used in consumer products as either ame retardants or plasticizers, as well as phthalates and phenols. These chemicals, or their metabolites, are commonly detected in the urine of pregnant women (9)(10)(11). Moreover, these chemicals are suspected to impact processes critical to the regulation of fetal growth, possibly through endocrine disruption or impacts on maternal oxidative stress and in ammation (1).…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

Bommarito

Welch

Keil

et al. 2020

Preprint

View full text Add to dashboard Cite

Background While fetal growth is a tightly regulated process, it is sensitive to environmental exposures that occur during pregnancy. Many commonly used consumer products contain chemicals that can disturb processes underlying fetal growth. However, mixtures of these chemicals have been minimally examined. We investigated associations between prenatal exposure to 33 consumer product chemicals (nine organophosphate ester flame retardant [OPE] metabolites, 12 phthalate metabolites, and 12 phenols) and the odds of small- or large-for-gestational age (SGA and LGA) births. Methods This case-control study was comprised of SGA (N = 31), LGA (N = 28), and appropriate for gestational age control (N = 31) births selected from the larger LIFECODES cohort. Biomarkers of exposure to consumer product chemicals were quantified in maternal urine collected from up to three study visits during pregnancy. In a single-pollutant approach, odds ratios (OR) and 95% confidence intervals (CI) of SGA and LGA associated with an interquartile range (IQR)-increase in exposure biomarkers were estimated using multinomial logistic regression. In a multi-pollutant approach, quantile g-computation was used to jointly estimate the OR (95% CI) of SGA and LGA per simultaneous one quartile-change in all biomarkers belonging to each chemical class. Results Among the 33 biomarkers analyzed, 20 were detected in at least 50% of the participants. After adjusting for potential confounders, we observed reduced odds of LGA in association with higher urinary concentrations of several exposure biomarkers. For example, an IQR-increase in the OPE metabolite, diphenyl phosphate, was associated with lower odds of LGA births (OR: 0.40 [95% CI: 0.18, 0.87]). Using quantile g-computation, we estimated lower odds of an LGA birth for lower OPE metabolites (OR: 0.49 [95% CI: 0.27, 0.89]) and phthalate metabolites (OR: 0.23 [95% CI: 0.07, 0.73]). Associations between consumer product chemicals and SGA were largely null. Conclusions Joint exposure to OPEs and phthalates was associated with lower odds of delivering LGA. Associations with LGA could indicate a specific impact of these exposures on the high end of the birth weight spectrum. Future work to understand this nuance in the associations between consumer product chemical mixtures and fetal growth is warranted.

show abstract

The association of urinary organophosphate ester metabolites and self-reported personal care and household product use among pregnant women in Puerto Rico

Cited by 29 publications

References 50 publications

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

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