The Association of Type Specific Hemolytic Streptococci With Acute Glomerulonephritis 1

Wertheim, Arthur R.; Lyttle, John D.; Loeb, Emily N.; Earle, David P.; Seegal, Beatrice Carrier; Seegal, David; Jost, Elizabeth L.; Davis, Grace; Saltzman, Mollie

doi:10.1172/jci102746

Cited by 42 publications

(6 citation statements)

References 12 publications

(9 reference statements)

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“…In addition to these observations Wright (111) reports the isolation of type 12 streptococci from 3 patients with acute nephritis in the Chicago area. Wertheim and his coworkers (112) (97) will show that in a large epidemic of nephritis occurring in the spring of 1952, the infecting strain, type 12, was associated with a high incidence of complications. These data would indicate that there may be straindifferences within organisms belonging to type 12.6…”

Section: Discussionmentioning

confidence: 99%

Acute Glomerulonephritis. The Significance of the Variations in the Incidence of the Disease 12

Rammelkamp¹,

Weaver²

1953

J. Clin. Invest.

134

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Section: Discussionmentioning

confidence: 99%

Acute Glomerulonephritis. The Significance of the Variations in the Incidence of the Disease 12

Rammelkamp¹,

Weaver²

1953

J. Clin. Invest.

134

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“…6 months later, proliferative glomerulonephritis with mesangial scarring, but without crescents, and several hyalinized glomeruli were found in biopsied kidney. Progressive deterioration of renal function followed (The New York Hospital, autopsy 22,412). The kidneys were one-half normal weight.…”

Section: Platementioning

confidence: 99%

The Experimental Induction of Glomerulonephritis Like That in Man by Infection With Group a Streptococci

Becker

Murphy

1968

The Journal of Experimental Medicine

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106 rabbits received one or more courses of inoculations, spaced 1–4 months apart, with Group A streptococci, usually of strains isolated from patients with acute glomerulonephritis. 8 days to a few weeks after onset of a given infection with streptococci known to have been nephritogenic for man, marked proteinuria, often with hematuria and occasionally with azotemia, was detected in 22 of the animals. 15 of these were sacrificed a few days to a few weeks thereafter, and 10 showed renal changes like those of acute or recurrent acute glomerulonephritis in man. Such changes occurred in three other rabbits whose urine was not examined that died or were sacrificed 1–3 wk after onset of infection with streptococci of a serotype known to include a strain nephritogenic for man. The remaining seven animals in which marked proteinuria had occurred died or were sacrificed many months later, in some cases after additional infections. Two of these had become azotemic and two convulsed and died after giving birth; in these animals, there were renal changes like those that occur in man in chronic latent glomerulonephritis, toxemia of pregnancy super-imposed on chronic latent glomerulonephritis, or chronic active glomerulonephritis. Anatomical changes in the kidneys in the experimentally induced and in naturally occurring glomerulonephritis, from acute to chronic stages, are compared and illustrated. The pathogenesis of poststreptococcal glomerulonephritis is discussed.

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“…Studies of established cases of acute nephritis have been reported by Rammelkamp and Weaver (1953), Wertheim et al (1953), Wilmers et al (1954), Hardin et al (1956), and Bernstein and Stillerman (1960). Two investigations on the production of type-specific antibodies are noteworthy-those of Cullhed et at.…”

mentioning

confidence: 97%

“…Only a minority of those infected by type 12 streptococci actually develop acute nephritis, and the incidence following type 12 infections varies (Rammelkamp, 1957). Other types have been isolated from cases of acute nephritis (Wertheim et al, 1953 ;Goldsmith et al, 1958 ;Mitchell, 1962). Urinary abnormalities without other signs of renal disease, while commoner and more notable after type 12 infections, may also occur after infection with other types, or after non-streptococcal infections (Stetson et al, 1955).…”

mentioning

confidence: 99%

Acute nephritis and streptococcal sore throat: a prospective study in general practice.

Higgins¹,

Abbot²,

James³

et al. 1965

BMJ

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The evidence linking acute nephritis and infection of the throat or skin with certain types of group A beta-haemolytic streptococci is of three kinds: (1) studies of streptococcal disease when acute nephritis was more prevalent than usual, (2) cultures from the throats of established cases of acute nephritis, and (3) serological studies of such cases for type-specific antibodies.Examples of the first are the reports of Manser and Wilson (1952), Reed (1953), Kleinman (1954), Seigel et al. (1955), Stetson et al. (1955), and George et al. (1958. Studies of established cases of acute nephritis have been reported by Rammelkamp and Weaver (1953), Wertheim et al. (1953), Wilmers et al. (1954, Hardin et al. (1956), andBernstein andStillerman (1960). Two investigations on the production of type-specific antibodies are noteworthy-those of Cullhed et at. (1959) and of Earle and Jennings (1959 (Ravenswaay, 1944, Rantz et al., 1945. In assessing the significance of such isolations it is essential to know the prevalence of different types in the community from which the cases are drawn. There are, however, few reports on the relative incidence of different types in acute pharyngitis in normal populations; what evidence there is suggests that type 12 is widely prevalent (Siegel et al., 1961 ; Mitchell, 1962Valkenburg et al., 1963.Moreover, the literature abounds in anomalies. Acute nephritis is said to be twice as common in males (Seegal et al., 1935 ;Earle and Seegal, 1957) has since appeared.We report here a prospective study in a normal community: in a small town and the neighbouring countryside, virtually the whole population of which is under our care. In 1959 this population numbered approximately 14,000 persons; the study began on 28 January of that year and continued for 12 months. * General Practitioners, Rugeley, Staffs.The objects were: (1) to determine the prevalence of different types of streptococci found in association with acute sore throat, (2) to uncover cases developing acute nephritis or urinary abnormalities after streptococcal pharyngitis, and (3) to relate them to the type of Streptococcus pyogenes isolated at the patient's first attendance. MethodAll patients with symptoms or signs of sore throat were admitted to the study. The throat was swabbed when the patient was first seen, and specimens of urine were tested. After three months it became necessary to reduce the number of urine specimens tested, and patients were asked thereafter to send in one specimen when first seen, and a second three weeks later. For the first nine months information (including details of temperature and treatment) was recorded on special cards; recording was then simplified and such details were omitted.Urines were tested by heat and acetic acid; if protein was found the urine was centrifuged and the deposit examined microscopically.Throat swabs were sent by post to the Public Health Laboratory 10 miles (16 km.) away (usually arriving within 24 hours) and were sown on to horse-blood agar plates, which were incubated aerobic...

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The Association of Type Specific Hemolytic Streptococci With Acute Glomerulonephritis 1

Cited by 42 publications

References 12 publications

Acute Glomerulonephritis. The Significance of the Variations in the Incidence of the Disease 12

Acute Glomerulonephritis. The Significance of the Variations in the Incidence of the Disease 12

The Experimental Induction of Glomerulonephritis Like That in Man by Infection With Group a Streptococci

Acute nephritis and streptococcal sore throat: a prospective study in general practice.

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