The association of trimethoprim-sulfamethoxazole with improved lung function in pediatric asthma

Eddens, Taylor; Wolfe, Rachel; Nowalk, Andrew; Forno, Erick; Campfield, Brian T

doi:10.1016/j.anai.2021.01.013

Cited by 1 publication

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…He had a good clinical course after treatment with TMP-SMX, corticosteroid therapy and long-term asthma control medications. This is consistent with recent studies suggesting that Pj can plays a role in both the pathophysiology and the exacerbation of asthma [ 24 , 25 ]. Importantly, all patients with SCID were considered and treated as PCP, which confirms that the presence of a P. jirovecii -positive specimen in a patient with SCID should be considered as an infection in progress.…”

Section: Discussionsupporting

confidence: 93%

“…Pj colonization status may correspond to a primary infection, as described in 20% of immunocompetent children between two and four years old, some with symptomatic forms [ 2 , 16 ]. Notably, data from different studies suggest a potential role of P. jirovecii in the progression of chronic pulmonary diseases [ 23 , 24 , 25 ]. In our cohort, 16 children in the Pj positive group had cardiopulmonary pathologies and chronic pulmonary pathologies such as asthma, hyaline membrane disease and bronchiolitis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age

Driouich

Luciani

et al. 2021

JoF

View full text Add to dashboard Cite

Few data are available in the literature regarding Pneumocystis jirovecii infection in children under 3 years old. This retrospective cohort study aimed to describe medically relevant information among them. All children under 3 years old treated in the same medical units from April 2014 to August 2020 and in whom a P. jirovecii evaluation was undertaken were enrolled in the study. A positive case was defined as a child presenting at least one positive PCR for P. jirovecii in a respiratory sample. Medically relevant information such as demographical characteristics, clinical presentation, microbiological co-infections, and treatments were collected. The objectives were to describe the characteristics of these children with P. jirovecii colonization/infection to determine the key underlying diseases and risk factors, and to identify viral respiratory pathogens associated. The PCR was positive for P. jirovecii in 32 children. Cardiopulmonary pathologies (21.9%) were the most common underlying disease in them, followed by severe combined immunodeficiency (SCID) (18.8%), hyaline membrane disease (15.6%), asthma (9.4%) and acute leukaemia (6.3%). All SCID children were diagnosed with pneumocystis pneumonia. Co-infection with Pj/Rhinovirus (34.4%) was not significant. Overall mortality was 18.8%. Paediatric pneumocystis is not restricted to patients with HIV or SCID and should be considered in pneumonia in children under 3 years old.

show abstract

Section: Discussionsupporting

confidence: 93%