The Association of Tibial Slope and Anterior Cruciate Ligament Rupture in Skeletally Immature Patients

O’Malley, Michael; Milewski, Matthew D.; Solomito, Matthew J.; Erwteman, Andrew S.; Nissen, Carl W.

doi:10.1016/j.arthro.2014.07.019

Cited by 54 publications

(48 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In previous studies, several studies have con rmed that IL-1β and IL-17 within synovial in ammation were associated with meniscus or cartilage degeneration as primary in ammatory mediators in humans or animals. Our study was in accord with these reporters [24,25]. High levels of IL-1β and IL-17 in knee traumatic areas demonstrated the level of meniscus or cartilage damage and the presence of a local in ammatory response that triggers early knee OA [26].…”

Section: Discussionsupporting

confidence: 81%

The underlying mechanism of partial anterior cruciate ligament injuries to the meniscus degeneration of knee joint in rabbit models

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The diagnosis, treatment and efficacy evaluation of anterior cruciate ligament (ACL) partial rupture remains controversial. This research aims to investigate the underlying mechanism of partial ACL injuries to the meniscus degeneration in the rabbit knee.Methods: Sixty New Zealand, white rabbits were randomly divided into three groups including an experimental group, a sham group (n=6) and and a blank control group (n=6). The experimental group is composed of an anteromedial bundle (AMB) rupture group (n=24), a posterolateral bundle (PLB) rupture group (n=24). Rabbits in the experimental group were subjected to right hind limbs knee surgery to induce ACL part injury under the arthroscopy. Finally, eight rabbits including 6 in the model group and 2 in the control group were sampled randomly on the second, fourth and eighth weeks respectively. We observed the typical form of the meniscus through HE staining. Expressions of inflammatory factors including interleukin-1β (IL-1β) and IL-17 in the knee joint fluid were determined by means of an ELISA. Analysis of the mRNA expressions of matrix metalloproteinases-13(MMP-13) was performed to evaluate the inflammatory mediators in the pathogenesis of the meniscus.Results: HE staining results showed that the surface was rough and the tissues were loose displaying collagen fibers of varying thickness. Both IL-1β and IL-17 in the synovial fluid, and the positive rate of MMP-13 in addition to MMP-13 mRNA showed a demonstrable increase treads from the 2nd to the 8th week. The significant difference was found (P<0.05) compared to the control group.Conclusion: We conclude that the elevated levels of IL-1β and IL-17, along with increased MMP13 expression, resulted in meniscus degradation in the rabbit knee joint model with partial ACL injury.

show abstract

Section: Discussionsupporting

confidence: 81%

The underlying mechanism of partial anterior cruciate ligament injuries to the meniscus degeneration of knee joint in rabbit models

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…A thorough understanding of injury mechanisms and risk factors is a crucial step towards the development of effective prevention programs. Risk factors for ACL injury have been examined in terms of environmental [72][73][74]100], anatomical [71,81,88,89], hormonal [9,84,102], genetic [37,79,86], and biomechanical/neuromuscular components [47,48,70,108,109]. However, environmental, anatomical, hormonal, and genetic risk factors are considered non-modifiable from a practical standpoint.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical and Neuromuscular Characteristics of Male Athletes: Implications for the Development of Anterior Cruciate Ligament Injury Prevention Programs

et al. 2015

View full text Add to dashboard Cite

Prevention of anterior cruciate ligament (ACL) injury is likely the most effective strategy to reduce undesired health consequences including reconstruction surgery, long-term rehabilitation, and pre-mature osteoarthritis occurrence. A thorough understanding of mechanisms and risk factors of ACL injury is crucial to develop effective prevention programs, especially for biomechanical and neuromuscular modifiable risk factors. Historically, the available evidence regarding ACL risk factors has mainly involved female athletes or has compared male and female athletes without an intra-group comparison for male athletes. Therefore, the principal purpose of this article was to review existing evidence regarding the investigation of biomechanical and neuromuscular characteristics that may imply aberrant knee kinematics and kinetics that would place the male athlete at risk of ACL injury. Biomechanical evidence related to knee kinematics and kinetics was reviewed by different planes (sagittal and frontal/coronal), tasks (single-leg landing and cutting), situation (anticipated and unanticipated), foot positioning, playing surface, and fatigued status. Neuromuscular evidence potentially related to ACL injury was reviewed. Recommendations for prevention programs for ACL injuries in male athletes were developed based on the synthesis of the biomechanical and neuromuscular characteristics. The recommendations suggest performing exercises with multi-plane biomechanical components including single-leg maneuvers in dynamic movements, reaction to and decision making in unexpected situations, appropriate foot positioning, and consideration of playing surface condition, as well as enhancing neuromuscular aspects such as fatigue, proprioception, muscle activation, and inter-joint coordination.

show abstract

“…The pathogenesis of ACL injury leading to OA has not been fully elucidated. Studying the mechanism can help physicians choose appropriate treatments for patients including surgery, drugs and tissue engineering to reduce the incidence of OA [22,23].…”

Section: Discussionmentioning

confidence: 99%

The underlying mechanism of partial anterior cruciate ligament injuries to the meniscus of knee joint in rabbit models

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background The diagnosis, treatment and efficacy evaluation of anterior cruciate ligament (ACL) remains controversial. This research aims to investigate the underlying mechanism of partial ACL injuries to the meniscus degeneration in rabbit knee. Methods Sixty New Zealand, white rabbits were randomly divided into three groups: the anteromedial bundle (AMB) splitting, the posterolateral bundle (PLB) splitting and a control group. Finally, eight rabbits were sampled randomly on the second, fourth and eighth weeks respectively. We observed the typical form of the meniscus through HE staining. Expressions of inflammatory factors including interleukin-1β (IL-1β) and IL-17 in the knee joint fluid were determined by means of an ELISA. Analysis of the mRNA expressions of MMP-13 was performed to evaluate the inflammatory mediators in the pathogenesis of the meniscus. Results HE staining results showed that the surface was rough and the tissues were loose displaying collagen fibers of varying thickness. Both IL-1β and IL-17 in the synovial fluid, and the positive rate of MMP-13 in addition to MMP-13 mRNA showed a demonstrable increase treads from the 2nd to the 8th week. The significant difference was found ( P <0.05) compared to the control group. Conclusion Our findings illustrated that the elevated levels of IL-1β and IL-17, along with increased MMP13 expression, resulting in meniscus degradation in the rabbit knee joint model with partial ACL injury. When the partial ACL injury on the different bundles occurred, the reconstruction of the reserved AMB or PLB must be operated on time due to uncertainty of conservative treatment.

show abstract

The Association of Tibial Slope and Anterior Cruciate Ligament Rupture in Skeletally Immature Patients

Cited by 54 publications

References 18 publications

The underlying mechanism of partial anterior cruciate ligament injuries to the meniscus degeneration of knee joint in rabbit models

The underlying mechanism of partial anterior cruciate ligament injuries to the meniscus degeneration of knee joint in rabbit models

Biomechanical and Neuromuscular Characteristics of Male Athletes: Implications for the Development of Anterior Cruciate Ligament Injury Prevention Programs

The underlying mechanism of partial anterior cruciate ligament injuries to the meniscus of knee joint in rabbit models

Contact Info

Product

Resources

About