2016
DOI: 10.1245/s10434-016-5446-2
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The Association of Surgical Margins and Local Recurrence in Women with Ductal Carcinoma In Situ Treated with Breast-Conserving Therapy: A Meta-Analysis

Abstract: Purpose There is no consensus on adequate negative margins in breast-conserving surgery (BCS) for ductal carcinoma in-situ (DCIS). We systematically review the evidence on margins in BCS for DCIS. Methods Study-level meta-analysis of local recurrence (LR), microscopic margin status and threshold distance for negative margins. LR proportion was modelled using random-effects logistic meta-regression (frequentist), and network meta-analysis (Bayesian) that allows for multiple margin distances per study, adjusti… Show more

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Cited by 133 publications
(61 citation statements)
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References 51 publications
(72 reference statements)
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“…15 The median proportion of patients receiving WBRT was 100% (interquartile range [IQR] 53.3–100.0%), and the median proportion receiving endocrine therapy was 20.8% (IQR 0.0–31.4%). The median follow-up was 78.3 months, and the median incidence of IBTR was 8.3% (IQR 5.0–11.9%).…”
Section: Resultsmentioning
confidence: 99%
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“…15 The median proportion of patients receiving WBRT was 100% (interquartile range [IQR] 53.3–100.0%), and the median proportion receiving endocrine therapy was 20.8% (IQR 0.0–31.4%). The median follow-up was 78.3 months, and the median incidence of IBTR was 8.3% (IQR 5.0–11.9%).…”
Section: Resultsmentioning
confidence: 99%
“…15 Briefly, using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Institute of Medicine guidelines, EMBASE, MEDLINE, PREMEDLINE, and evidence-based medicine databases were searched in October 2014 for eligible studies. A summary providing details of the methodology and statistical approaches is provided in the Appendix.…”
Section: Methodsmentioning
confidence: 99%
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“…[7], выполнена оценка влияния ширины края ре-зекции (0,1 мм против 2 мм, 3 или 5 мм и 10 мм) на про-гноз. В исследовании участвовали 7883 пациента со средним периодом наблюдения 6,5 года.…”
Section: размер первичной опухоли (характер ростаunclassified