The Association of Streptococcus gallolytics Subspecies Pasteurianus Bacteremia With the Detection of Premalignant Colonic Lesions

Association of bacteremias of Streptococcus gallolyticus with the development of colorectal cancer in people 65 years of age

“…Unfortunately, this association has been underestimated in the medical community, and the nomenclature trap in the literature and laboratories makes bacterial identification difficult. However, through the observation and adequate and timely monitoring of the patient, due to the possible pathogenic role of Streptococcus gallolyticus in colorectal cancer, it is possible to perform an early diagnosis and potentially curative treatment that saves the patient's life 4,5,[9][10][11][12][13][14][15][22][23][24] Therefore, the detection of this bacterial group in blood cultures or serum levels of elevated IgG antibodies against Streptococcus gallolyticus indicates the need for an evaluation to establish the origin of bacteremia and the presence of possible complications. 3,18,23,24 The present analysis describes a series of case reports that represent the evidence that exists between bacteraemia due to S. gallolyticus and its association with the presence of colorectal cancer and colorectal adenomas in patients with an average age of 65 years.…”

“…of colon through a report in which he made a complete evaluation of 15 patients with bacteraemia due to S. gallolyticus. 1,6,8,10,[13][14][15] With the report of Klein, a barrier that prevented directly related to Streptococcus was overcome gallolyticus with colorectal cancer, since through this study it was possible to formally establish the association that S. gallolyticus bacteremia has with the concomitant development of colorectal cancer, malignant or pre-malignant colorectal neoplasms and even with gastrointestinal neoplasms. This additionally suggests with certainty the performance of colonoscopy exams in infected patients, since the performance of colonoscopy after S. gallolyticus bacteremia could allow the detection of colorectal neoplasms in early or precancerous stages in affected patients, and thus, its clinical evolution would be beneficial for the reduction of morbidity and general mortality.…”

“…[1][2][3][4][5][6][7][8][9][10][11] Multiple factors can lead to the transformation of healthy intestinal mucosa to cancer, both inheritance and environmental factors such as personal and/or family history of colorectal cancer and adenomatous polyps, hereditary syndromes, diet (fat consumption) and obesity, physical inactivity, alcoholism, smoking, inflammatory bowel disease (such as ulcerative colitis) and pot agents Essentially infectious. [10][11][12][13] Specifically in patients with bacteremia due to S. gallolyticus, according to statistics, the most associated factors are obesity, alcohol abuse, smoking, diabetes mellitus, gastrointestinal surgery and cancer present or ancient. 14 S. gallolyticus was first associated with colorectal cancer and infectious endocarditis in 1951 by McCoy and Mason, however it was not until 1977 that S. gallolyticus was recognized by Robert Klein as the pathogen specifically related to the concomitant development of cancer.…”

“…[16][17][18] Possible pathogenic mechanisms lie at the molecular level and could be involved in uncontrolled cell proliferation that involves various factors such as the nuclear factor kB (NFkB), free radicals and protein kinases activated by mitogens, and which may be the responsible for the progression of pre-neoplastic colorectal lesions associated with bacteremia due to S. gallolyticus that lead to the development of colorectal cancer. 4,10,16,19,[20][21][22][23][24] The bacterium S. gallolyticus is part of the microbiota in 2.5-15% of the total population, however, its increase in fecal load is frequent in patients with bacteremia, probable pre-neoplastic or neoplastic lesions and/ or endocarditis, and that the bacteria follows a selective pathway of adhesion to collagen and histone as protein A for collagen I, IV, fibronectin and fibrinogen. From the active colonization of S. gallolyticus, its growth is activated in the colorectal tissue.…”

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“…[5][6][7][8] The literature analyzed suggests that the age of prevalence in patients with S. gallolyticus bacteremia is 65 years (± 12 years) on average, and a predominance of male patients. [1][2][3][4][5][6][7][8][9][10][11] Multiple factors can lead to the transformation of healthy intestinal mucosa to cancer, both inheritance and environmental factors such as personal and/or family history of colorectal cancer and adenomatous polyps, hereditary syndromes, diet (fat consumption) and obesity, physical inactivity, alcoholism, smoking, inflammatory bowel disease (such as ulcerative colitis) and pot agents Essentially infectious. [10][11][12][13] Specifically in patients with bacteremia due to S. gallolyticus, according to statistics, the most associated factors are obesity, alcohol abuse, smoking, diabetes mellitus, gastrointestinal surgery and cancer present or ancient.…”