The association of smoking with contact dermatitis and hand eczema – a review

Zimmer, Katelyn Anderson; Armbrecht, Eric S.; Burkemper, Nicole M.

doi:10.1111/ijd.13777

Cited by 17 publications

(10 citation statements)

References 33 publications

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“…It therefore remains difficult to interpret causal relationships for lifestyle factors associated with the lifetime prevalence of hand eczema. Previous studies 27,28 also reported that exposed to cigarette smoking is a risk factor for hand eczema, but neither this study nor the Danish TOACS cohort 15 could confirm that relationship, and this inconsistency may differentiate between active and passive smoking. Passive smoking was the main exposure in this cohort.…”

Section: Discussioncontrasting

confidence: 80%

Lifetime prevalence and determinants of hand eczema in an adolescent population in Germany: 15‐year follow‐up of the LISA cohort study

Wang

Tischer

Standl

et al. 2021

Acad Dermatol Venereol

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Background Hand eczema is a common inflammatory skin disorder in both adolescence and adulthood. Objectives We sought to assess the lifetime prevalence of hand eczema and associated exogenous and endogenous risk factors among adolescents in Germany. Methods This was a cross‐sectional study embedded into a prospective population‐based birth cohort in four regions of Germany, which recruited healthy neonates born between November 1997 and January 1999. We included 1736 participants who had completed the 15‐year follow‐up from birth cohort and 84.6% (1468/1736) had clearly reported whether they have ever had hand eczema. All the data were based on questionnaires and blood tests (immunoglobulin E). Multivariable logistic regression analysis was used to examine endogenous and exogenous factors in relation to the lifetime prevalence of hand eczema among adolescents. Results One thousand four hundred and sixty‐eight adolescents (715 girls, 48.7%) were included in the final analysis. The lifetime prevalence of hand eczema among adolescents at the age of 15 was 10.4% (95% confidence interval [CI]: 8.9%–12.1%), with a significantly higher lifetime prevalence among girls than boys (12.7% vs. 8.2%, P = 0.005). Multivariable logistic regression analysis indicated statistically significant associations between the lifetime prevalence of hand eczema and having ever been diagnosed with atopic dermatitis (aOR = 1.8, 95% CI: 1.1–2.8) or having ever had dry skin (aOR = 1.9, 95% CI: 1.1–3.1), respectively. No statistically significant independent associations were found between asthma, hay fever, allergy‐related clinical symptoms, immunoglobulin E positivity and other exogenous factors in relation to hand eczema. Conclusion Our study fills a research gap on the epidemiological burden of hand eczema among adolescents. One out of ten ever suffered from hand eczema until age 15 years indicating that hand eczema constitutes a significant burden in paediatric populations. The role of atopic dermatitis in hand eczema reinforces previous findings. Exogenous risk factors warrant further investigation.

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Section: Discussioncontrasting

confidence: 80%

Lifetime prevalence and determinants of hand eczema in an adolescent population in Germany: 15‐year follow‐up of the LISA cohort study

Wang

Tischer

Standl

et al. 2021

Acad Dermatol Venereol

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“…Also important are antimicrobial peptides and alarmins, skin tight junctions, natural moisturizing factors, immunoproteomes, proteases, lipids, smoking, etc. ( 24 , 25 ).…”

Section: The Pathomechanisms Of Contact Dermatitismentioning

confidence: 99%

Irritant and Allergic Contact Dermatitis – Skin Lesion Characteristics

Novak-Bilić

Vučić

Japundžić

et al. 2018

ACC

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SUMMARY – Contact skin lesions may be the consequences of contact with various irritants or allergens, or due to other factors (e.g., UV radiation, microbials), intrinsic factors (e.g., in autoimmune responses), or even their combination. There are many substances related to irritant contact dermatitis (CD), causing irritant or toxic effects, e.g., chemical and physical agents, plants, phototoxic agents, airborne irritants, etc. Impaired barrier function (e.g., aberrancies in epidermal pH buffering capabilities) also participates by promoting bacterial biofilms and creating an environment favoring sensitization. Development of allergic CD skin lesions includes complex immune pathways and inflammatory mediators, influenced by both genetic (predominantly filaggrin mutations) and environmental triggers. In the pathogenesis of allergic CD, antimicrobial peptides play a prominent role; they are produced by various skin cells (e.g., keratinocytes, sebocytes) and move to inflamed lesions during an inflammation process. Also, in allergic CD skin lesions, the skin shows different types of immune responses to individual allergens, although clinical manifestations do not depend on the causative allergen type, e.g., nickel stimulates immune activation primarily of the Th1/Th17 and Th22 components. Also important are alarmins, proteases, immunoproteomes, lipids, natural moisturizing factors, tight junctions, smoking, etc. We expect that future perspectives may reveal new pathogenetic factors and scientific data important for the workup and treatment of patients with CD.

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“…Smoking increases the risk of contact dermatitis [ 94 , 95 ] and hand eczema [ 96 , 97 ]. The mechanism is still controversial in part [ 98 ]; however, cigarettes enhance the Th1 immune response and IFN-γ cytokine production [ 99 , 100 , 101 ], whereas nicotine itself seems to suppress the immune reaction, including dendritic cell maturation and T cell activation and migration [ 102 ].…”

Section: Daily Lifestyle and Inflammatory Skin Diseasesmentioning

confidence: 99%

Daily Lifestyle and Inflammatory Skin Diseases

Sawada

Saito‐Sasaki

Mashima

et al. 2021

IJMS

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Throughout life, it is necessary to adapt to the Earth’s environment in order to survive. A typical example of this is that the daily Earth cycle is different from the circadian rhythm in human beings; however, the ability to adapt to the Earth cycle has contributed to the development of human evolution. In addition, humans can consume and digest Earth-derived foods and use luxury materials for nutrition and enrichment of their lives, as an adaptation to the Earth’s environment. Recent studies have shown that daily lifestyles are closely related to human health; however, less attention has been paid to the fact that obesity due to excessive energy intake, smoking, and alcohol consumption contributes to the development of inflammatory skin diseases. Gluten or wheat protein, smoking and alcohol, sleep disturbance, and obesity drive the helper T (Th)1/Th2/Th17 immune response, whereas dietary fiber and omega-3 fatty acids negatively regulate inflammatory cytokine production. In this review, we have focused on daily lifestyles and the mechanisms involved in the pathogenesis of inflammatory skin diseases.

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The association of smoking with contact dermatitis and hand eczema – a review

Cited by 17 publications

References 33 publications

Lifetime prevalence and determinants of hand eczema in an adolescent population in Germany: 15‐year follow‐up of the LISA cohort study

Lifetime prevalence and determinants of hand eczema in an adolescent population in Germany: 15‐year follow‐up of the LISA cohort study

Irritant and Allergic Contact Dermatitis – Skin Lesion Characteristics

Daily Lifestyle and Inflammatory Skin Diseases

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