The Association of Sex with Unplanned Cardiac Readmissions following Percutaneous Coronary Intervention in Australia: Results from a Multicentre Outcomes Registry (GenesisCare Cardiovascular Outcomes Registry)

Abstract

Background and aim: Unplanned cardiac readmissions in patients with percutaneous intervention (PCI) is very common and is seen as a quality indicator of in-hospital care. Most studies have reported on the 30-day cardiac readmission rates, with very limited information being available on 1-year readmission rates and their association with mortality. The aim of this study was to investigate the impact of biological sex at 1-year post-PCI on unplanned cardiac readmissions. Methods and results: Patients enrolled into the GenesisCare Cardiovascular Outcomes Registry (GCOR-PCI) from December 2008 to December 2020 were included in the study. A total of 13,996 patients completed 12 months of follow-up and were assessed for unplanned cardiac readmissions. All patients with unplanned cardiac readmissions in the first year of post-PCI were followed in year 2 (post-PCI) for survival status. The rate of unplanned cardiac readmissions was 10.1%. Women had a 29% higher risk of unplanned cardiac readmission (HR 1.29, 95% CI 1.11 to 1.48; p = 0.001), and female sex was identified as an independent predictor of unplanned cardiac readmissions. Any unplanned cardiac readmission in the first year was associated with a 2.5-fold higher risk of mortality (HR 2.50, 95% CI 1.67 to 3.75; p < 0.001), which was similar for men and women. Conclusion: Unplanned cardiac readmissions in the first year post-PCI was strongly associated with increased all-cause mortality. Whilst the incidence of all-cause mortality was similar between women and men, a higher incidence of unplanned cardiac readmissions was observed for women, suggesting distinct predictors of unplanned cardiac readmissions exist between women and men.

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

“…An Australian registry of individuals who had undergone PCI (N=13 996) from 2008 to 2020 determined that female sex was associated with increased 2-year readmission (HR, 1.29 [95% CI, 1.11–1.48]) compared with male sex. 121…”

Special Issue “Clinical Frontiers in Percutaneous Coronary Intervention”

“…Including consecutive patients from January 2015 to January 2019 treated exclusively with either Xience stents ( n = 1000) or bare metal stents (BMSs) ( n = 500), the adverse clinical event rates were low at the 12-month follow-up with a comparable major adverse cardiac event rate (MACE). The aim of an important study by Conradie et al was to examine the impact of sex at 1-year post-PCI on unplanned cardiac rehospitalizations [ 7 ]. A large cohort of patients ( n = 13,996) was assessed for unplanned cardiac rehospitalizations within the first year post-PCI, and those admitted were followed in year 2 (post-PCI) for their survival status.…”