The association of severe aplastic anaemia with the philadelphia chromosome and the bcr/abl transcript

Sica, Simona; Chiusolo, Patrizia; Zollino, Marcella; Sorà, Federica; Piccirillo, Nicola; Laurenti, Luca; Reddiconto, Giovanni; Leone, Giuseppe

doi:10.1046/j.1365-2141.2001.03006-9.x

Cited by 1 publication

(2 citation statements)

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“…In three cases of aplastic anaemia patients with Ph 1 chromosome, cytogenetic abnormalities were detected at the onset of leukaemia. In this patient, Ph 1 chromosome could be detected at the phase of aplastic anaemia, which was similar to the finding in two cases reported by Suzan et al (3) and Sica et al (7).…”

Section: Discussionsupporting

confidence: 92%

“…Ph 1 chromosome is the result of a t(9;22) reciprocal chromosomal translocation that is detectable in 95% of patients with chronic myeloid leukaemia and 20% of those with adult acute lymphocytic leukaemia. While 6.7% of patients have clonal cytogenetic abnormalities of bone marrow cells at their diagnosis of aplastic anaemia (5), the acquisition of Ph 1 chromosome has rarely been observed in aplastic anaemia (3, 6, 7). In three cases of aplastic anaemia patients with Ph 1 chromosome, cytogenetic abnormalities were detected at the onset of leukaemia.…”

Section: Discussionmentioning

confidence: 99%

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Aplastic anaemia associated with a Philadelphia chromosome and monosomy 7 during immunosuppressive therapy

Satoh

Miwa

Daimaru

et al. 2003

European J of Haematology

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We describe a patient who presented with aplastic anaemia associated with the Philadelphia (Ph1) chromosome during immunosuppressive therapy and who subsequently developed myelodysplastic syndrome (MDS) with monosomy 7. Initially the patient had hypocellular fatty marrow without leukaemic blasts or dysplastic features. Chromosome analysis showed 46, XY, t(9;22)(q34;q11) during immunosuppressive therapy, but no leukaemic transformation was detected. The patient showed gradual haematologic improvement and became transfusion independent. Thereafter, bone marrow dysplasia with monosomy 7 progressed following transfusion independence. These findings indicate that multiple cytogenetic evolutions occur in aplastic anaemia during immunosuppressive therapy, and that Ph1 chromosome may play a role in bone marrow suppression rather than development of leukaemia.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%