The association of serum gamma glutamyltransferase with components of the metabolic syndrome in the Korean adults

Kang, Yang Ho; Min, Hong Ki; Son, Seok Man; Kim, In Joo; Kim, Yong Ki

doi:10.1016/j.diabres.2006.11.009

Cited by 58 publications

(41 citation statements)

References 25 publications

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“…CRP originates in the liver and is increased in people with liver steatosis [32], suggesting a link between chronic inflammation and non-alcoholic fattyliver disease. The association of GGT with insulin resistance, fasting blood glucose and triacylglycerols [33][34][35] and type 2 diabetes [22][23][24] is well described.…”

Section: Discussionmentioning

confidence: 99%

Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis

et al. 2009

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Aims/hypothesis We examined the association between serum C-reactive protein (CRP) and incident diabetes in a prospective study, and added these data to a literature-based meta-analysis to explore potential sources of heterogeneity between studies. Methods We analysed a case-control study nested within the European Prospective Investigation of Cancer (EPIC)-Norfolk cohort, including 293 incident diabetes cases and 708 controls. We combined 16 published studies on CRP and incident diabetes in a random-effect meta-analysis. Results In the EPIC-Norfolk cohort, serum CRP was associated with a higher risk of diabetes after adjusting for age, sex, BMI, family history of diabetes, smoking and physical activity (OR 1.49, comparing the extreme thirds of CRP distribution [95% CI 1.03-2.15], p=0.03). However, the association was completely attenuated after further adjustment for WHR, serum γ-glutamyltransferase and serum adiponectin (OR 1.00; 95% CI 0.66-1.51, p=1.0). In a meta-analysis of 16 published studies with 3,920 incident diabetes cases and 24,914 controls, the RR was 1.72 (95% CI 1.54-1.92), comparing the extreme thirds of CRP distribution, with substantial heterogeneity between studies (I 2 =52.8%, p=0.007). Conclusions/interpretation Initial evidence of association between CRP and incident diabetes was confounded by central adiposity, markers of liver dysfunction and adiponectin in the primary analysis. Despite an overall positive association in the meta-analysis, considerable heterogeneity existed between studies. The degree of adjustment for central adiposity and baseline glycaemia explained some of this heterogeneity and suggests that CRP may not be an independent risk factor for type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis

et al. 2009

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“…Previous studies have shown that serum GGT is associated with MetS and its characteristic components in both genders 15,25) . Although the detailed mechanism underlying the relationship between GGT levels and MetS is not completely understood, hepatic insulin resistance may be involved [26][27][28] . MetS represents a cluster of cardiovascular disease risk factors for which insulin resistance is believed to be of pathogenic importance.…”

Section: Discussionmentioning

confidence: 99%

Association between γ-Glutamyltransferase, Adiponectin and Arterial Stiffness

Park

Kang

Yoo

et al. 2012

JAT

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Aim: Serum -glutamyltransferase (GGT) is used as a marker of hepatic dysfunction. Recently, several studies reported that GGT is significantly associated with cardiovascular mortality and atherosclerosis. Adiponectin is known to play an important role in the development of atherosclerosis, but its physiologic role has yet to be fully determined. In this study, we investigated the relationships among serum GGT, adiponectin and arterial stiffness. Methods: Of 4236 subjects recruited from 17 different medical centers in Seoul, Korea, 2846 subjects were enrolled in our study. The parameters of metabolic syndrome (MetS) were assessed in these subjects, and their plasma adiponectin levels and pulse wave velocity (PWV) were measured along with anthropometric and biochemical profiles, including GGT. Results: The subjects were stratified into 3 groups according to GGT values. PWV values gradually increased and the adiponectin level decreased with GGT tertiles. Aortic PWV showed a significant correlation with age, SBP, FPG, but there was no correlation among aortic PWV, GGT and adiponectin. Peripheral PWV demonstrated a significant correlation with age, SBP, DBP, BMI, WC, FPG and GGT, but there was no correlation between peripheral PWV and adiponectin. In multiple logistic regression analysis after adjusting for risk factors, GGT was a significant contributor to increased peripheral PWV. Conclusions: These findings indicate that serum GGT is independently associated with increased arterial stiffness, but there was no correlation between adiponectin and arterial stiffness in both males and females. J Atheroscler Thromb, 2012; 19:90-97.

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“…Serum GGT is associated with hypertension, dyslipidemia, and abnormal glucose tolerance, suggesting that it is related to hepatic insulin resistance rather than non-alcoholic fatty liver disease (Ikai et al 1994;Nilssen and Førde 1994;Kang et al 2007). GGT plays a direct role in the generation of reactive oxygen species in the presence of iron or other transition metals (Brown et al 1998), inducing lipid peroxidation in human biological membranes (Paolicchi et al 1997), and is an indirect marker of antioxidant systems, with the primary function of maintaining the intracellular concentration of glutathione in response to oxidative stress (Karp et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Gamma-Glutamyl Transferase Level and Prehypertension among Community-Dwelling Men

Kawamoto

Kohara

Tabara

et al. 2008

Tohoku J. Exp. Med.

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Serum gamma-glutamyl transferase (GGT) activity is a general clinical marker of excessive alcohol consumption, and GGT reflects changes in oxidative stress and implicated in the progression of hypertension. Recent guidelines classify persons with above-optimal blood pressure (BP) but not clinical hypertension as having prehypertension for a systolic BP (SBP) of 120 to 139 mmHg and/or a diastolic BP (DBP) of 80 to 89 mmHg; however, only limited data are available on the association between serum GGT and this entity among community-dwelling men in Japan. We performed a cross-sectional study to examine whether serum GGT was associated with prehypertension. Study participants (754 men, age 56 ± 15 years) without a clinical history of stroke, transient ischemic attack, myocardial infarction, angina, or renal failure were recruited from a single community. Thirty-seven percent of participants had prehypertension and 39.3% had hypertension. Multiple regression analysis using SBP and DBP as objective variables, adjusted for risk factors as explanatory variables, showed that log GGT was significantly and independently associated with elevated SBP (β = 0.109, P = 0.006) and DBP (β = 0.238, P < 0.001). Compared with participants in the lowest tertile of serum GGT (< 29 IU/L), the multivariate-adjusted odds ratio (OR) (95% CI) for prehypertension was 1.73 (1.06-2.81) for the middle tertile (29-53 IU/L) and 2.37 (1.31-4.31) for the highest tertile (> 53 IU/L). Moreover, the respective ORs for hypertension were 1.82 (1.04-3.18) and 3.11 (1.61-6.03). These results suggest that higher serum GGT levels are associated with prehypertension or hypertension in the general male population. gamma-glutamyl transferase; hypertension; prehypertension; risk factor; Japanese men. Tohoku

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The association of serum gamma glutamyltransferase with components of the metabolic syndrome in the Korean adults

Cited by 58 publications

References 25 publications

Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis

Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis

Association between γ-Glutamyltransferase, Adiponectin and Arterial Stiffness

Association between Serum Gamma-Glutamyl Transferase Level and Prehypertension among Community-Dwelling Men

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The association of serum gamma glutamyltransferase with components of the metabolic syndrome in the Korean adults

Cited by 58 publications

References 25 publications

Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis

Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis

Association between &gamma;-Glutamyltransferase, Adiponectin and Arterial Stiffness

Association between Serum Gamma-Glutamyl Transferase Level and Prehypertension among Community-Dwelling Men

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Association between γ-Glutamyltransferase, Adiponectin and Arterial Stiffness