The Association of Selected Cancers With Service in the US Military in Vietnam

Suskind, Raymond R.

doi:10.1001/archinte.1990.00390230009002

Cited by 8 publications

(1 citation statement)

References 26 publications

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“…Several studies suggest at least a modest association between Agent Orange exposure and NHL mortality, including studies with matched veteran controls deployed in areas without spraying. The Selected Cancers Study showed that Vietnam service was associated with a 47% increased incidence of NHL (odds ratio 1.47; 95% CI: 1.1-2.0) [21]. However, the lack of a clear exposure-risk gradient, the overall modest effect, the long latency period and the unknown long-term mechanism of carcinogenesis have made it difficult to establish causality [22][23][24].…”

Section: Agent Orange and Non-hodgkin Lymphomamentioning

confidence: 99%

Extranodal Diffuse Large B-Cell Lymphoma of Bone and Soft Tissue Presenting With Marked Lymphedema and Hypercalcemia

Shabbir¹,

Kojadinovic²,

Gidfar³

et al. 2022

Cureus

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Extranodal involvement is more prevalent in diffuse large B-cell lymphoma (DLBCL) compared to other non-Hodgkin lymphoma subtypes, with up to 40% of patients with early-stage disease having at least one extranodal site. Virtually any tissue can be involved, but primary skeletal muscle and bone DLBCL is exceedingly rare. Here we report a case of DLBCL of the humerus and proximal limb musculature in a Vietnam War combat veteran with significant Agent Orange exposure and untreated hepatitis C infection. The patient presented with 1,25-dihydroxyvitamin D3-mediated malignant hypercalcemia and massive soft tissue infiltration. He had an excellent treatment response to chemotherapy and involved field radiation therapy. Also, we discuss hepatitis C and Agent Orange in the context of the pathogenesis and management of DLBCL.

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