The association of renin-angiotensin system genes with the progression of hepatocellular carcinoma

Ye, Guanxiong; Qin, Yong; Lu, Xin; Xu, Xiangdong; Xu, Shengqian; Wu, Chengjun; Wang, Xinmei; Wang, Shi; Pan, Debiao

doi:10.1016/j.bbrc.2015.02.030

Cited by 43 publications

(53 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ACE2/Ang-(1–7)/MasR axis, which represents a newly discovered component of the RAS, has been shown to be up-regulated or down-regulated in different cancers. Yu et al (2016) suggested that ACE2 expression is decreased in breast cancer, NSCLC (Feng et al, 2010), hepatocellular carcinoma (Ye et al, 2015), and pancreatic cancer (Zhou et al, 2009), and Zong et al (2015) reported that ACE2 levels are lower in gallbladder cancer cells than in normal gallbladder cells. Ang-(1–7) is generated primarily from Ang I or AngII via enzymatic cleavage; in recent studies, ACE2 has been identified as the main enzyme that generates Ang-(1–7), whereas ACE has been shown to be responsible for cleaving Ang-(1–7) to produce Ang-(1–5).…”

Section: Introductionmentioning

confidence: 99%

The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer

Fan

et al. 2017

Front. Physiol.

View full text Add to dashboard Cite

Cancer remains one of the most common causes of death and disability and represents a major economic burden in industrialized nations. The renin-angiotensin system (RAS) has been well-recognized as one of the most important regulators of both normal and pathological physiological processes in the brain, kidney, heart, and blood vessels. The activation of the angiotensin-converting enzyme 2/angiotensin-(1–7)/mitochondrial assembly receptor [ACE2/Ang-(1–7)/MasR] axis, which is one component of the RAS, has recently been identified as a critical component of pulmonary systems, gastric mucosa, and cancer. However, the ability of the ACE2/Ang-(1–7)/MasR axis to suppress or promote cancer has not been fully elucidated. In this review, we focus on recent experimental and clinical studies investigating the basic properties, roles, and mechanisms of ACE2, Ang-(1–7), and the MasR, as well as the axis pathway, to provide insights into possible therapeutic strategies for treating cancer that target the ACE2/Ang-(1–7)/MasR axis.

show abstract

Section: Introductionmentioning

confidence: 99%

The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer

Fan

et al. 2017

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…HCC patients were shown to have low expression of ACE2, although Ang-II, ang-1-7 and VEGF were high levels in the patient [30].…”

Section: The Local Renin-angiotensin System In Liver and Hepatocellulmentioning

confidence: 99%

“…RAS activation was reported in the patients with liver cirrhosis [30,31], liver inflammation [12], nonalcoholic fatty liver disease [12], and fibrosis [4,9]. RAS triggers oxidative stress at liver [32].…”

Section: The Function Of Local Renin-angiotensin Systems In the Livermentioning

confidence: 99%

“…Hepatocellular carcinoma (HCC) has been reported to be the most prevalent type of cancer throughout worldwide [30], being the fifth most predominant tumor case [17]. The patient with HCC has been informed to have only 5 years survival due to metastasis and recurrence based on angiogenesis [30].…”

Section: The Local Renin-angiotensin System In Liver and Hepatocellulmentioning

confidence: 99%

“…The patient with HCC has been informed to have only 5 years survival due to metastasis and recurrence based on angiogenesis [30]. HCC is one of the most severe complications of cirrhosis [6].…”

Section: The Local Renin-angiotensin System In Liver and Hepatocellulmentioning

confidence: 99%

See 2 more Smart Citations

Local Renin-Angiotensin System at Liver and Crosstalk with Hepatic Diseases

Taşkın¹,

Güven²

2017

Renin-Angiotensin System - Past, Present and Future

View full text Add to dashboard Cite

The systemic renin-angiotensin system mainly regulates blood pressure and maintains kidney function. Recent studies have realized that renin-angiotensin system (RAS) has been found in many tissues, such as heart, liver, and kidney. Although RAS in heart and kidney has been well documented, the RAS in the liver has been evaluated in a few studies. Therefore, this chapter will be assessed it. Based on findings, RAS in the liver has presented almost all of its components, such as angiotensin-I (Ang-I), angiotensin-II (Ang-II), angiotensin-converting enzyme (ACE), angiotensin type-1 receptor (AT1), angiotensin type-2 receptor (AT2), named as classical RAS. Expect these components, the local RAS has had alternative pathway components, including angiotensin-converting enzyme 2 (ACE2) and chymase. Classical RAS has an opposite effect of alternative RAS.Although these local RAS might not be such a crucial for the tissue, it could be a more vital function under pathophysiologic conditions. The chapter the local RAS in the liver the under both physiologic and pathophysiologic conditions is highlighted.

show abstract

CD34 cells in somatic, regenerative and cancer stem cells: Developmental biology, cell therapy, and omics big data perspective

Kapoor

Bose

2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

The transmembrane phosphoglycoprotein protein CD34 has conventionally been regarded as a marker for hematopoietic progenitors. Its expression on these cells has been leveraged for cell therapy applications in various hematological disorders. More recently, the expression of CD34 has also been reported on cells of nonhematopoietic origin. The list includes somatic cells such as endothelial cells, fibrocytes and interstitial cells and regenerative stem cells such as corneal keratocytes, muscle satellite cells, and muscle-derived stem cells. Furthermore, its expression on some cancer stem cells (CSCs) has also been reported. Till date, the functional roles of this molecule have been implicated in a multitude of cellular processes including cell adhesion, signal transduction, and maintenance of progenitor phenotype. However, the complete understanding about this molecule including its developmental origins, its embryonic connection, and associated functions is far from complete. Here, we review our present understanding of the structure and putative functions of the CD34 molecule based upon our literature survey. We also probed various biological databases to retrieve data related to the expression and associated molecular functions of CD34. Such information, upon synthesis, is hence likely to provide the suitability of such cells for cell therapy.Moreover, we have also covered the existing cell therapy and speculated cell therapy applications of CD34 + cells isolated from various lineages. We have also attempted here to speculate the role(s) of CD34 on CSCs. Finally, we discuss number of large-scale proteomics and transcriptomics studies that have been performed using CD34 + cells.

show abstract

The association of renin-angiotensin system genes with the progression of hepatocellular carcinoma

Cited by 43 publications

References 24 publications

The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer

The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer

Local Renin-Angiotensin System at Liver and Crosstalk with Hepatic Diseases

CD34 cells in somatic, regenerative and cancer stem cells: Developmental biology, cell therapy, and omics big data perspective

Contact Info

Product

Resources

About