The association of renal cell carcinoma with gastrointestinal stromal tumors

Abstract

Background and Objectives Prior small studies have reported a possible association between renal cell carcinoma (RCC) and gastrointestinal stromal tumors (GISTs). In the largest known series, our objective was to describe the prevalence of RCC among patients with GISTs over 26 years at Memorial Sloan Kettering Cancer Center (MSKCC). Methods We retrospectively reviewed MSKCC’s prospectively maintained sarcoma and RCC databases and identified all patients with both RCC and GIST between 1980 and 2016. Demographic and clinicopathological characteristics were obtained. Results 9/405 (2.2%) GIST patients were identified with RCC, with a mean follow-up of 9.2 [Range 3.8 – 28.4] years. 5/9 (55.6%) patients had RCC and GIST diagnosis within 6 months of each other. Mean RCC tumor size was 3.0 [Range 1.8 – 8] cm and 8/9 (88.9%) patients were RCC stage 1. 4/9 (44.4%) patients had papillary RCC (pRCC) histology, 5/9 (55.6%) had additional alternative malignancies, and 4/9 (44.4%) had primary small bowel GIST. Conclusions Our series suggests a possible association of RCC with GISTs. In addition, we found a high frequency of pRCC histology, alternative malignancies and small bowel GISTs in co-occurring RCC-GIST patients. Further investigation to identify genetic mutations, in this population, would assist in surveillance and treatment.

Association Between Gastrointestinal Stromal Tumors and Other Malignancies: It Is Only a Matter of Time ? A Case Series and an Overview of Systematic Reviews

“…The frequency of synchronous or metachronous SPTs in patients with GIST, is widely variable among different studies published in the literature [11,13,14,16]. In the present study, a frequency of 17.9% has been detected, while our overview of systematic reviews shows that the cumulative prevalence rate of SPTs ranges from 9.3% in the study by Agaimy et al [7] to 18.0% in the study by Diamantis et al [24], with a mean prevalence rate of 14.5%.…”

“…Outside of these syndromic forms, little is known about the sporadic coexistence of GISTs with SPTs, although multiple single institution and population-based studies have reported GIST patients to have an increased risk of presenting with additional malignancies, either synchronously or during follow-up [7,[11][12][13][14].…”

“…The frequency of these associations and the spectrum of malignancies involved have been mainly described in the literature in form of case reports and case series, insufficient to prove if gene mutations or the effect of common carcinogenic pathways on adjacent tissues may be possible explanations for the onset of SPTs [7,14].…”

The association of genitourinary cancer among Saudi patients with gastrointestinal stromal tumors and a systematic literature review

“…Out of the three cases, two were CRCC, and the radiological features of the third were suggestive of papillary RCC. This is not surprising as papillary RCC prevalence in GIST patients is much proportionally higher 14,23 . The GISTs in our GU cancer patients were incidental during planned nephrectomy or adrenalectomy.…”

“…A total of 69 articles were reviewed. Seventeen articles reported the prevalence of genitourinary cancer associated with GIST ranging 2.1-15.6% (Table 2) [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] . Prostatic adenocarcinoma was the most common primary genitourinary cancer (2.1-14%), followed by RCC (0.6-11.4%).…”