The association of renal artery calcification with hypertension in community-living individuals: the multiethnic study of atherosclerosis

Thomas, Isac C.; Ratigan, Amanda R.; Rifkin, Dena E.; Ix, Joachim H.; Criqui, Michael H.; Budoff, Matthew J.; Allison, Matthew A.

doi:10.1016/j.jash.2015.12.003

Cited by 10 publications

(3 citation statements)

References 28 publications

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“…Numerous studies have addressed the clinical importance of arterial calcification among CKD patients and cardiovascular high-risk patients [10–12, 14, 19–21]. Our previous study suggested that aortic calcification burden has a negative effect on postoperative renal function in renal transplant patients, [14] and the preoperative condition of aortic calcification has a significant impact on postoperative persistent hypertension after unilateral adrenalectomy in patients with aldosterone-producing adenomas.…”

Section: Discussionmentioning

confidence: 99%

Clinical relevance of aortic calcification in urolithiasis patients

et al. 2017

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BackgroundThe aim of the present study is to investigate the clinical relevance of aortic calcification in urolithiasis patients.MethodsBetween January 2010 and September 2014, 1221 patients with urolithiasis were treated in Oyokyo Kidney Research Institute and Hirosaki University Hospital. Among these, 287 patients (Stone group) on whom adequate data were available were included in this retrospective study. We also selected 148 subjects with early stage (pT1N0M0) renal cell carcinoma from 607 renal cell carcinoma patients who underwent radical nephrectomy at Hirosaki University Hospital (Non-stone group) as control subjects. Validity of the Non-stone group was evaluated by comparison with pair-matched 296 volunteers from 1166 subjects who participated in the Iwaki Health Promotion Project in 2014. Thereafter, age, body mass index, aortic calcification index (ACI), renal function, serum uric acid concentrations, and comorbidities (diabetes, hypertension, or cardiovascular disease) were compared between the Non-stone and Stone groups. Independent factors for higher ACI and impaired renal function were assessed using multivariate logistic regression analysis.ResultsWe confirmed relevance of Non-stone group patients as a control subject by comparing the pair-matched community-dwelling volunteers. Backgrounds of patients between the Non-stone and Stone groups were not significantly different except for the presence of hypertension in the Stone group. ACI was not significantly high in the Stone group compared with the Non-stone group. However, age-adjusted ACI was greater in the Stone group than the Non-stone group. Among urolithiasis patients, ACI was significantly higher in uric acid containing stone patients. The number of patients with stage 3B chronic kidney disease (CKD) was significantly higher in the Stone group than in the Non-stone group (12% vs. 4%, P = 0.008). Multivariate logistic regression analysis showed higher aortic calcification index (>13%), and being a stone former were independent factors for stage 3B CKD at the time of diagnosis.ConclusionAortic calcification and being a stone former had harmful influence on renal function. This study was registered as a clinical trial: UMIN: UMIN000022962.

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Section: Discussionmentioning

confidence: 99%

Clinical relevance of aortic calcification in urolithiasis patients

et al. 2017

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“…One such predictor is elevated pulse pressure (PP) hypertension, which can be seen as a marker of arterial senescence and stiffening [5][6][7][8]. A positive correlation exists between calcification in the renal arteries, hypertension, and renal disease [9][10][11]. Oxygen delivery index (DO 2 I) has also been shown to be independently associated with AKI in retrospective studies and in one prospective, randomized trial [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Is Calcium Score in the Abdominal Aorta or Renal Arteries Predictive of Acute Kidney Injury After Cardiopulmonary Bypass: An Exploratory Study

Mitrev¹,

Germaine²,

Crudeli³

et al. 2022

Cureus

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IntroductionAcute kidney injury (AKI) remains a serious complication after surgery with cardiopulmonary bypass (CPB). A relationship similar to the one between coronary artery calcification and increased incidence of cardiac complications is hypothesized to exist for aortic calcification and the development of AKI. Elevated pulse pressure (PP) hypertension has been shown to be a predictor of AKI-CPB (AKI after CPB surgery), and calcium deposition and stiffening of the body's conduit arteries may be part of this process. We hypothesized that calcium scores obtained from non-contrast computed tomography (CT) scans of the infrarenal aorta and renal arteries would be independently and significantly associated with AKI-CPB. MethodsWe conducted a retrospective study of 65 subjects who underwent non-emergent open heart surgery with CPB in a tertiary healthcare center. AKI-CPB was diagnosed using the Acute Kidney Injury Network criteria. Aortic and renal artery calcium (Agatston) scores were obtained and entered into a multivariable logistic regression model alongside other significant predictors of AKI-CPB from a univariable analysis. ResultsPulse pressure, body surface area, and pre-operative serum creatinine were significantly associated with the development of AKI-CPB, but the calcium scores were not. For PP, the odds ratio (OR) was 1.062, (95% Wald confidence interval {CI}=1.012 -1.114). The OR for the calcium score in the aorta was 1.0000 (95% CI=1.0 -1.0). ConclusionsAgatston calcium scores in the renal arteries and infrarenal aorta were not independently associated with AKI-CPB, but arterial stiffening, as indicated by elevated pulse pressure, was predictive of AKI-CPB.

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“…Aortic calcification is one of the sequelae of aortic degeneration and has recently been considered a major complication and independent risk factor for coronary artery disease, heart failure, and stroke [ 9 , 10 ]. Several studies have addressed the clinical importance of arterial calcification in patients at high risk for cardiovascular disease; however, only a few studies have demonstrated the impact of arterial calcification on renal function [ 11 – 13 ]. In addition, the clinical relevance of the aortic calcification index (ACI) with regard to postoperative renal function outcome in patients undergoing radical nephrectomy has not been well studied.…”

Section: Introductionmentioning

confidence: 99%

Aortic calcification burden predicts deterioration of renal function after radical nephrectomy

et al. 2017

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BackgroundRadical nephrectomy for renal cell carcinoma (RCC) is a risk factor for the development of chronic kidney disease (CKD), and the possibility of postoperative deterioration of renal function must be considered before surgery. We investigated the contribution of the aortic calcification index (ACI) to the prediction of deterioration of renal function in patients undergoing radical nephrectomy.MethodsBetween January 1995 and December 2012, we performed 511 consecutive radical nephrectomies for patients with RCC. We retrospectively studied data from 109 patients who had regular postoperative follow-up of renal function for at least five years. The patients were divided into non-CKD and pre-CKD based on a preoperative estimated glomerular filtration rate (eGFR) of ≥60 mL/min/1.73 m2 or <60 mL/min/1.73 m2, respectively. The ACI was quantitatively measured by abdominal computed tomography before surgery. The patients in each group were stratified between low and high ACIs. Variables such as age, sex, comorbidities, and pre- and postoperative renal function were compared between patients with a low or high ACI in each group. Renal function deterioration-free interval rates were evaluated by Kaplan-Meier analysis. Factors independently associated with deterioration of renal function were determined using multivariate analysis.ResultsThe median age, preoperative eGFR, and ACI in this cohort were 65 years, 68 mL/min/1.73 m2, and 8.3%, respectively. Higher ACI (≥8.3%) was significantly associated with eGFR decline in both non-CKD and pre-CKD groups. Renal function deterioration-free interval rates were significantly lower in the ACI-high than ACI-low strata in both of the non-CKD and pre-CKD groups. Multivariate analysis showed that higher ACI was an independent risk factor for deterioration of renal function at 5 years after radical nephrectomy.ConclusionsAortic calcification burden is a potential predictor of deterioration of renal function after radical nephrectomy.Trial registrationThis study was registered as a clinical trial: UMIN000023577 Electronic supplementary materialThe online version of this article (doi:10.1186/s12894-017-0202-x) contains supplementary material, which is available to authorized users.

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The association of renal artery calcification with hypertension in community-living individuals: the multiethnic study of atherosclerosis

Cited by 10 publications

References 28 publications

Clinical relevance of aortic calcification in urolithiasis patients

Clinical relevance of aortic calcification in urolithiasis patients

Is Calcium Score in the Abdominal Aorta or Renal Arteries Predictive of Acute Kidney Injury After Cardiopulmonary Bypass: An Exploratory Study

Aortic calcification burden predicts deterioration of renal function after radical nephrectomy

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