The association of plasma fibrinogen with clinicopathological features and prognosis in esophageal cancer patients

Liu, Fang-Teng; Gao, Hui; Wu, Changwen; Zhu, Zhengming

doi:10.18632/oncotarget.21746

Cited by 14 publications

(9 citation statements)

References 36 publications

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“…Conversely, Li et al 12 revealed that Fib was not associated with the OS of ESCC. Recently, two meta-analyses revealed that plasma Fib was a prognostic indicator in patients with EC 13,14 . However, the present study revealed that Fib was not associated with CSS or OS in ESCC patients.…”

Section: Discussionmentioning

confidence: 99%

“…Although recent studies have reported that plasma Fib was related to cancer progression and prognosis in various cancers [7][8][9] , the role of plasma Fib in EC remains controversial [10][11][12] . Recently, two metaanalyses revealed that plasma Fib was a prognostic indicator in patients with EC 13,14 . As a nutritional factor, albumin (ALB) reflected the nutritional status in a variety of cancers, including patients with EC 15,16 .…”

Section: Introductionmentioning

confidence: 99%

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A Novel Prognostic Index in Patients with Resectable Esophageal Squamous Cell Carcinoma: Fibrinogen/Prealbumin Ratio

Feng¹,

Wang²,

Jiang³

et al. 2020

RIC

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Background: Fibrinogen (Fib) to albumin (ALB) fibrinogen-to-albumin ratio as a prognostic index for esophageal cancer has been confirmed. A novel prognostic index was initially proposed with fibrinogen to prealbumin ratio (FPR) in patients with resectable esophageal squamous cell carcinoma (ESCC). Objective: The objective of the study was to study the prognostic role of the novel prognostic index (FPR) in patients with resectable ESCC without any neoadjuvant treatment. Methods: In this retrospective study, a total of 372 resectable ESCC patients without any neoadjuvant treatment were included. The best cutoff values were selected by the receiver operating characteristic curves. Two Cox regression analyses with forward stepwise (one for categorical variables and the other for continuous variables) were used to evaluate the overall survival (OS) and cancer-specific survival (CSS). Results: The best cutoff point was 0.014 for FPR. Patients with lower levels of FPR (≤0.014) had better CSS (50.7% vs. 18.0%, p < 0.001) and OS (48.0% vs. 17.6%, p < 0.001) than patients with higher levels of FPR (> 0.014). Multivariate Cox analyses (categorical and continuous) demonstrated that FPR was an independent prognostic factor in CSS (cat

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Novel Prognostic Index in Patients with Resectable Esophageal Squamous Cell Carcinoma: Fibrinogen/Prealbumin Ratio

Feng¹,

Wang²,

Jiang³

et al. 2020

RIC

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“…Recently, a number of meta-analysis had reported the prognostic role of elevated plasma fibrinogen in a variety of tumors, including, epithelial ovarian cancer 50 , Renal Cell Carcinoma 51 , esophageal cancer 52 . To the best of our knowledge, this meta-analysis was the first study to systematically assess the prognostic value of plasma fibrinogen in lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Plasma Fibrinogen in Lung Cancer Patients: A Meta-Analysis

et al. 2018

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Background: The prognostic role of plasma fibrinogen in lung cancer remains controversial. The aim of this meta-analysis was to assess the prognostic value of plasma fibrinogen in lung cancer.Methods: We performed a systematic literature search to identify eligible studies in PubMed, Embase and the Cochrane Library database. The hazard ratios (HR) and their 95% confidence intervals (CI) were collected from these eligible studies and were used to assess the relationship between plasma fibrinogen and lung cancer.Results: A total of 16 studies including 6,881 patients were selected in this meta-analysis. The results showed that elevated plasma fibrinogen in lung cancer patients was correlated with poor overall survival (OS) (HR = 1.38, 95% CI: 1.22-1.55, P < 0.001) and disease-free survival (DFS) / progress-free survival (PFS). (HR = 1.29, 95% CI: 1.01-1.65, P = 0.042). When stratified by cut-off value for OS and DFS/PFS, there was no significant heterogeneity. And the results of “cut-off value ≥ 400mg/dl” group showed that the high level of fibrinogen in serum was associated with worse OS and DFS/PFS of lung cancer. In further subgroup analysis by tumor histology, high plasma fibrinogen was also associated with worse OS in non-small cell lung cancer (NSCLC) (HR = 1.32, 95% CI: 1.14-1.53, P < 0.001). However, there was no significant association between high plasma fibrinogen and poor DFS in NSCLC patients (HR = 1.24, 95% CI: 0.97-1.57, P = 0.08). The Egger's regression test indicated evidence of publication bias for DFS/PFS.Conclusions: Elevated plasma fibrinogen, particularly defined as a plasma fibrinogen concentration of ≥ 400mg/dl, could be a promising indicator for worse OS in lung cancer patients, including NSCLC.

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“…The Newcastle-Ottawa Scale (NOS) was used for quality assessment [15,16]. A study with NOS scores ≥6 was considered as "high-quality" [16,17].…”

Section: Data Extraction and Quality Assessmentmentioning

confidence: 99%

Calpain Small Subunit 1 Protein in the Prognosis of Cancer Survivors and Its Clinicopathological Correlation

Tang

Yin

Liu

et al. 2019

BioMed Research International

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Background/Aims. Calpain small subunit 1 (Capn4) is implicated in tumorigenesis and plays a key role in multiple tumors. This study aimed to fully illustrate the prognostic value of Capn4 protein in cancer patients. Methods. A systematic search was conducted against several online databases. Hazard ratios (HRs) or odds ratio (ORs) were used to investigate the relationship between Capn4 protein expression and prognosis as well as clinical parameters in cancer survivors. Results. Eleven studies involving 1775 patients were identified. Overall, the results showed that Capn4 protein was associated with poor prognosis of overall survival (OS) (HR=1.74; 95% CI:1.47-2.01; p<0.001) and event-free survival (EFS) (HR=1.73; 95% CI:1.39-2.07; p<0.001) in various cancers. And expression of Capn4 protein was related to depth of invasion (OR= 4.17; 95% CI: 1.42-12.27; p=0.01), venous invasion (OR=2.34; 95% CI: 1.07-5.13; p=0.03), lymph node metastasis (2.74; 95% CI: 1.98-3.79; p<0.001), distant metastasis (OR=4.02; 95% CI: 2.14-7.57; p<0.001), and clinical stage (OR=2.87; 95% CI: 1.94-4.26; p<0.001), whereas expression of the Capn4 protein was not associated with gender (OR=1.09; 95% CI: 0.86-1.39; p=0.47) and tumor differentiation (OR=1.16; 95% CI: 0.90-2.23; p=0.25). Conclusions. Expression of Capn4 protein is associated with cancer survival and clinicopathologic characteristics in patients.

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The association of plasma fibrinogen with clinicopathological features and prognosis in esophageal cancer patients

Cited by 14 publications

References 36 publications

A Novel Prognostic Index in Patients with Resectable Esophageal Squamous Cell Carcinoma: Fibrinogen/Prealbumin Ratio

A Novel Prognostic Index in Patients with Resectable Esophageal Squamous Cell Carcinoma: Fibrinogen/Prealbumin Ratio

Prognostic Value of Plasma Fibrinogen in Lung Cancer Patients: A Meta-Analysis

Calpain Small Subunit 1 Protein in the Prognosis of Cancer Survivors and Its Clinicopathological Correlation

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