The association of PASI scores with CRH-R1 expression in patients with psoriasis

Cemil, Bengü Çevirgen; Canpolat, Filiz; Yılmazer, Demet; Eskioğlu, Fatma; Alper, Murat

doi:10.1007/s00403-012-1218-4

Cited by 23 publications

(17 citation statements)

References 27 publications

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“…It has been suggested that by activating CRH, stress provokes degranulation of the mast cells, releasing pro-inflammatory cytokines and exacerbating the psoriasis. [24][25][26][27][28] Cervigen Cemil et al 29 demonstrated increased expression of the CRH-R1 receptor in plaques of psoriasis which may play a part in the etiopathogenesis of this disorder. The cytokines secreted during psoriasis (TNF-alpha, interferon-alpha, interleukins 1 and 6) inhibit serotonin synthesis and increase CRH production, enhancing stress and explaining depressive disorders and predisposition to stress.…”

Section: Introductionmentioning

confidence: 99%

Stress and psoriasis

Rousset

Halioua

2018

Int J Dermatology

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The links between psoriasis and stress are complex. This article proposes a review of the literature on the relationship between stress and psoriasis. In 31-88% of cases, patients report stress as being a trigger for their psoriasis. There was also a reported higher incidence of psoriasis in subjects who had a stressful event the previous year, suggesting that stress may have a role in triggering the disease in predisposed individuals. Stress is also a consequence of psoriasis outbreaks. Understanding the role of stress makes it appropriate to target stress when proposing treatment to patients with psoriasis. Several controlled studies have demonstrated that relaxation, hypnosis, biofeedback, and behavioral and cognitive stress management therapies have been effective in people with psoriasis.

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Section: Introductionmentioning

confidence: 99%

Stress and psoriasis

Rousset

Halioua

2018

Int J Dermatology

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Section: Discussionmentioning

confidence: 99%

“…Previous studies revealed the functional role of the CRH/CRH-R1 system in pathological human skin conditions [ 7 , 11 ]. Cemil et al reported the expression of the CRH-R1 in psoriatic skin and its correlation with PASI scores [ 11 ]. In the present study, for the first time we evaluated the protein expression of CRH-R1 in the lesions of LP patients by immunohistochemistry and found the expression of CRH-R1 to be higher in these lesions than in the normal control skin.…”

Section: Discussionmentioning

confidence: 99%

“…For staining intensity, the following four-point scale was used: grade 0 – no staining; grade 1 – mild staining; grade 2 – moderate staining; grade 3 – strong staining. The percentage of CRH-R1 expression was defined as the percentage of positive staining cells; grade 0 for negative, grade 1 for 1–33% positive, grade 2 for 34–66% positive, and grade 3 for 67–100% positive [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

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Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?

Cemil¹,

Yılmazer²,

Ataş³

et al. 2017

pdia

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IntroductionLichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis.AimTo determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP.Material and methodsThirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group.ResultsThe comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls (p < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients.ConclusionsOur study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions.

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“…These patients are also at risk for cardiovascular disease, diabetes, and hypertension. CRF signaling occurs in skin, and is involved in local inflammatory responses [103], and has been associated with the intensity of psoriasis [104]. Given the systemic and local inflammatory state of psoriasis patients and the role of inflammation in these other diseases associated with psoriasis, it may be that in a similar manner, inflammation and associated local CRF/steroid hormone signaling within the inner ear could be contributors to SSNHL.…”

Section: Future Directionsmentioning

confidence: 99%

Cellular signaling protective against noise-induced hearing loss – A role for novel intrinsic cochlear signaling involving corticotropin-releasing factor?

Vetter

2015

Biochemical Pharmacology

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Hearing loss afflicts approximately 15% of the world's population, and crosses all socioeconomic boundaries. While great strides have been made in understanding the genetic components of syndromic and non-syndromic hearing loss, understanding of the mechanisms underlying noise-induced hearing loss (NIHL) have come much more slowly. NIHL is not simply a mechanism by which older individuals loose their hearing. Significantly, the incidence of NIHL is increasing, and is now involving ever younger populations. This may predict future increased occurrences of hearing loss. Current research has shown that even short-term exposures to loud sounds generating what was previously considered temporary hearing loss, actually produces an almost immediate and permanent loss of specific populations of auditory nerve fibers. Additionally, recurrent exposures to intense sound may hasten age-related hearing loss. While NIHL is a significant medical concern, to date, few compounds have delivered significant protection, arguing that new targets need to be identified. In this commentary, we will explore cellular signaling processes taking place in the cochlea believed to be involved in protection against hearing loss, and highlight new data suggestive of novel signaling not previously recognized as occurring in the cochlea, that is perhaps protective of hearing. This includes a recently described local hypothalamic-pituitary-adrenal axis (HPA)-like signaling system fully contained in the cochlea. This system may represent a local cellular stress-response system based on stress hormone release similar to the systemic HPA axis. Its discovery may hold hope for new drug therapies that can be delivered directly to the cochlea, circumventing systemic side effects.

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The association of PASI scores with CRH-R1 expression in patients with psoriasis

Cited by 23 publications

References 27 publications

Stress and psoriasis

Stress and psoriasis

Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?

Cellular signaling protective against noise-induced hearing loss – A role for novel intrinsic cochlear signaling involving corticotropin-releasing factor?

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