The association of osteopontin and LMX1A expression with World Health Organization grade in meningiomas and gliomas

Tsai, Wen‐Chiuan; Lee, Herng‐Sheng; Lin, Chih‐Kung; Chen, Ann; Nieh, Shin; Ma, Hsin‐I

doi:10.1111/j.1365-2559.2012.04277.x

Cited by 21 publications

(22 citation statements)

References 50 publications

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“…Since six distinct somatic mutations in the LMX1A gene were previously reported in gliomas (COSMIC database; cancer.sanger.ac.uk [94]), potential postnatal functions of LMX1A can be suspected. Evidence also supports a correlation between LMX1A immunostaining intensity and the grading system of primary brain tumors in meningiomas and some gliomas (see [95] and Section 4.2 for details). In mDA neurons, the expression of Lmx1a in postmitotic neurons diminishes with aging, but significant levels remain present in the adult brain [81,91,96].…”

Section: Lmx1a and Lmx1b Maintain Neuronal Homeostasis In The Adult Bmentioning

confidence: 69%

“…A growing body of evidence has shown that LMX1A plays an important role in cancer. Briefly, immunohistological analysis of brain tumors has shown that the LMX1A protein level correlates with grades of meningiomas and some gliomas, except for grade IV gliomas in which Lmx1a staining is weaker than grade III [95]. The LMX1A expression level can also predict the grade and aggressiveness of ovarian [120] and pancreatic cancers [121].…”

Section: Role Of In Human Cancersmentioning

confidence: 99%

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Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b

Doucet-Beaupré

Ang²,

Lévesque

2015

FEBS Letters

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a b s t r a c t LIM-homeodomain (LIM-HD) proteins are evolutionary conserved developmental transcription factors. LIM-HD Lmx1a and Lmx1b orchestrate complex temporal and spatial gene expression of the dopaminergic pathway, and evidence shows they are also involved in adult neuronal homeostasis. In this review, the multiple roles played by Lmx1a and Lmx1b will be discussed. Controlled Lmx1a and Lmx1b expression and activities ensure the proper formation of critical signaling centers, including the embryonic ventral mesencephalon floor plate and sharp boundaries between lineagespecific cells. Lmx1a and Lmx1b expression persists in mature dopaminergic neurons of the substantia nigra pars compacta and the ventral tegmental area, and their role in the adult brain is beginning to be revealed. Notably, LMX1B expression was lower in brain tissue affected by Parkinson's disease. Actual and future applications of Lmx1a and Lmx1b transcription factors in stem cell production as well as in direct conversion of fibroblast into dopaminergic neurons are also discussed. A thorough understanding of the role of LMX1A and LMX1B in a number of disease states, including developmental diseases, cancer and neurodegenerative diseases, could lead to significant benefits for human healthcare.

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Section: Lmx1a and Lmx1b Maintain Neuronal Homeostasis In The Adult Bmentioning

confidence: 69%

Section: Role Of In Human Cancersmentioning

confidence: 99%

Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b

Doucet-Beaupré

Ang²,

Lévesque

2015

FEBS Letters

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“…Meanwhile, OPN as a multifunctional protein has also been involved in every single step of cancer progression including cancer cell adhesion, tumor invasion, metastasis and angiogenesis [6–8]. Moreover, OPN was overexpressed in different solid tumors, including, but not limited to breast cancer [9], non-small cell lung cancer [10], colorectal cancer [11], hepatocellular carcinoma [12] and glioma [13]. Accumulated studies [14–23] also measured the OPN expression in primary tumor tissues or plasma in GC patients and investigated the clinical relevance between OPN and survival outcomes.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of osteopontin expression in gastric cancer: a meta-analysis

Gao

et al. 2016

Oncotarget

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BackgroundAccumulated studies have exploited the association between osteopontin (OPN) expression and survival of patients with gastric cancer (GC), however, the results were controversial. Thus, we performed a meta-analysis, aiming to investigate the prognostic role of OPN for GC patients and to explore the association between OPN and clinicalpathological features of GC.ResultsA total of ten studies involving 1775 patients were included in final meta-analysis. Of the included studies, nine were conducted on Asian patients and one was performed on Caucasian patients. Regarding OPN detection, immunohistochemistry (IHC) was used on tissue specimens in eight studies and enzyme linked immunosorbent assay (ELISA) was used on plasma specimens in two studies. The pooled data showed that high OPN expression was correlated with poor OS (HR = 1.59, 95% CI: 1.15–2.22, p = 0.006). Subgroup analyses demonstrated that OPN had enhanced prognostic value for Asian patients (HR = 1.64, 95% CI = 1.11–2.41, p = 0.012) and for patients receiving surgical resection (HR = 1.6, 95% CI = 1.04–2.48, p = 0.034). In addition, the results also showed that elevated OPN expression was associated with lymph node metastasis, TNM stage, depth of invasion, tumor size and distant metastasis in GC.MethodsRelevant studies were retrieved through PubMed, Embase and Web of Science. Combined hazard ratio (HR) and 95% confidence interval (CI) were calculated to assess the association between OPN and overall survival (OS). Subgroup analyses and publication bias were also conducted.ConclusionsOPN overexpression was correlated with poor OS and clinical features reflecting high aggressiveness in patients with GC. OPN was a promising prognostic biomarker for GC.

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“…At present, many studies have shown that the abnormal expression of OPN is closely related to the occurrence and development of liver cancer, colon cancer and some gynecological malignancies. The mechanism may be that OPN promotes the formation of new blood vessels, chemotactic transfer of cytokines, adhesion and extracellular matrix, while inhibiting apoptosis in varying degrees [20].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of serum osteopontin levels in small-cell lung cancer

Wang

et al. 2020

Preprint

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BackgroudOsteopontin (OPN) is involved in the development and metastasis of a variety of tumors. This study explored serum OPN levels in patients with small cell lung cancer (SCLC) and compared them with healthy controls.MethodsThe OPN levels of 96 patients with SCLC before and after first-line chemotherapy were detected by enzyme-linked immunosorbent assay (ELISA) and compared with 60 healthy controls.ResultsThe pre-treatment serum OPN levels of patients with SCLC were higher than those of healthy controls (P<0.001). Serum OPN levels were significantly associated with disease stage, tumor size, and lymph node metastasis (P=0.012, 0.034, and 0.037, respectively). Serum OPN levels were significantly decreased after first-line chemotherapy (P=0.019), which was associated with treatment response (P=0.011), but there was no significant difference with pre-treatment OPN levels (P=0.485). Cox proportional hazard analysis showed that serum OPN levels, disease stage, and performance status were independent predictors of overall survival.ConclusionsOur results suggest that serum OPN levels can be used as biomarkers to predict treatment response and survival in patients with SCLC.

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The association of osteopontin and LMX1A expression with World Health Organization grade in meningiomas and gliomas

Abstract: Higher immunostaining intensity for OPN and LMX1A correlated with WHO grades for meningiomas and some gliomas. Contrary to our expectations, LMX1A staining in WHO grade IV gliomas was shown to be weaker than in WHO grade III tumours.

Cited by 21 publications

References 50 publications

Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b

Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b

Prognostic significance of osteopontin expression in gastric cancer: a meta-analysis

Prognostic significance of serum osteopontin levels in small-cell lung cancer

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