The association of oral contraceptive pills with increase in intraocular pressure: Time for pharmacovigilance to step in

Bhanwra, Sangeeta; Ahluwalia, Kaza

doi:10.4103/0976-500x.149150

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…American Academy of Ophthalmology (AAO) 2013 Annual Meeting reported that women using OCP for more than three years had two folds increased risk of developing glaucoma 3 . Later, similar reports were published showing that women using OCP for more than five years had a 25 percent increased risk of POAG 9,10,11 .…”

Section: Graphmentioning

confidence: 75%

Effect of Short-term Use of Oral Contraceptive Pills on Intraocular Pressure

Malik¹

2019

pak J Ophthalmol

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Purpose: To study the effect of short-term use of oral contraceptive pills on intra-ocular pressures of women of childbearing age. Study Design: Observational case control study. Place and Duration of Study: The study was conducted at Arif memorial teaching hospital and Allied hospital Faisalabad from October 2017 to March 2018. Material and Methods: There were 100 female subjects, who were divided into two groups of 50 each. Group A, included females, who had been taking oral contraceptive pills (OCP) for more than 6 months and less than 36 months. Group B, included 50 age-matched controls, who had never used OCP. Ophthalmic and systemic history was taken. Careful Slit lamp examination was performed and intraocular pressures (IOP) were measured using Goldman Applanation tonometer. Fundus examination was done to rule out any posterior segment disease. We compared the intra ocular pressures between the two groups by using Student t test. Results: Average age was 29.16 in group A and 27.74 years in group B. Average duration of using OCP was 14.9 months. Mean IOP in right eye was 13.08 � 1.41 mm of Hg and 13.34 � 1.27 mm of Hg in left eye in Group A. While, mean IOP in right eye was 11.72 � 1.35 mm of Hg and in left eye was 11.92 � 1.3 mm of Hg in controls. Significant difference was noted between the IOP of OCP group and controls. (p = 0.000). Conclusion: OCP significantly increases IOP even when used for short time period. Key words: Oral contraceptive pills, Intra-ocular pressure, Glaucoma.

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Section: Graphmentioning

confidence: 75%

Effect of Short-term Use of Oral Contraceptive Pills on Intraocular Pressure

Malik¹

2019

pak J Ophthalmol

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“…As past experience shows, serious consequences of these products have been brought to light by research in pharmacovigilance. Among these consequences are leukemia in children of mothers who have taken oral contraceptive pills, [11] depression and even suicidal action in association with certain pills for contraception, [12] the possibility of glaucoma causally related to hormonal contraception, [13] and a heightened risk of breast cancer for women taking oral contraceptives. [14] In addition a serious impact on the quality of life owing to oral contraceptive pills has been described.…”

Section: Resultsmentioning

confidence: 99%

How Women in Search of Suitable Contraceptive Methods can Remedy the Lack of Counseling and Circumvent Untrustworthy Information Disseminated by Various Media

2019

ARC Journal of Gynecology and Obstetrics

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Background:The urgent need for appropriate counseling regarding contraceptive options is a well-known phenomenon in the clinical practice. Recent events show that this need has not yet been met. On the background of this evidence, new avenues are explored to enable women to remedy the lack of adequate counseling and circumvent untrustworthy information disseminated by various media. Material and Method: Material used comprises publications in leading medical journals with the highest impact factors, publications by manufacturers and by the internationally most influential health agencies.This material is subjected to a methodological analysis which is guided by the bioethical principles of nil nocere and informed consent.

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“…[ 141 ] Long-term use of OCPs has also been associated with increased risk of glaucoma, especially when used for 3 years or more. [ 142 143 ]…”

Section: Hoice Of O Ral C mentioning

confidence: 99%

Consensus statement on the use of oral contraceptive pills in polycystic ovarian syndrome women in India

Patil¹

2018

J Hum Reprod Sci

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Objective:To provide consensus recommendations for health-care providers on the use of oral contraceptive pills (OCPs) in polycystic ovarian syndrome (PCOS) women in India.Participants:Extensive deliberations, discussions, and brainstorming were done with different fraternities (specialists) being involved. These included endocrinologists, gynecologists, reproductive endocrinologists, dermatologists, public health experts, researchers, and a project manager with a team to develop the guideline.Evidence:Published literature was retrieved through searches of Medline and The Cochrane Database from January 2003 to December 2017 using appropriate-controlled vocabulary (e.g., oral contraceptive pills, polycystic ovarian syndrome, long term outcomes, infertility). Clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies' publications and data were also reviewed to suggest the recommendations.Process:The working group for guideline committee included members from the PCOS Society (India), Indian Society for Assisted Reproduction, The Mumbai Obstetric and Gynecological Society, The Endocrine Society of India, Indian Association of Dermatologists, Venereologists and Leprologists, Cosmetic Dermatology Society (India), Academicians from Medical Colleges, National Institute for Research in Reproductive Health, and a Research Associate. The core team included five reproductive endocrinologists, five gynecologists, five dermatologists, three endocrinologists, two public health experts and one research associate.Conclusions:This consensus statement provides the guidance/recommendations for Indian practitioners regarding the use of OCP in women with PCOS. PCOS is one of the common endocrinopathies encountered in gynecological/endocrine practice. The spectrum of this disorder may range from prepubertal girls with premature pubarche, young girls with hirsutism, acne and anovulatory cycles, married women with infertility, and elderly women. Although obesity is a common feature for most PCOS patients, 'lean PCOS' also exists. For several years, OCPs have played an important role in the symptom management of PCOS women. This is due to the fact that OCPs decrease the luteinizing hormone, reduce androgen production, and increase sex hormone-binding globulin, which binds androgens. Several new formulations of OCPs have been developed to decrease the side effects. This includes use of less androgenic progestins and lower doses of ethinyl estradiol. These consensus recommendations help the health provider to choose the right type of OCPs, which will alleviate the symptoms with least side effects. It also gives insight into the indications, contraindications, and concerns regarding its short, intermediate and long-term use.

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The association of oral contraceptive pills with increase in intraocular pressure: Time for pharmacovigilance to step in

Cited by 3 publications

References 4 publications

Effect of Short-term Use of Oral Contraceptive Pills on Intraocular Pressure

Effect of Short-term Use of Oral Contraceptive Pills on Intraocular Pressure

How Women in Search of Suitable Contraceptive Methods can Remedy the Lack of Counseling and Circumvent Untrustworthy Information Disseminated by Various Media

Consensus statement on the use of oral contraceptive pills in polycystic ovarian syndrome women in India

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