The Association of Openness Personality Trait with Stress-Related Salivary Biomarkers in Burning Mouth Syndrome

Souza, Fabrício Tinôco Alvim de; Kümmer, Arthur; Silva, Maiza L V; Amaral, Tânia Mp; Abdo, Evandro Neves; Abreu, Mauro Henrique Nogueira Guimarães de; Silva, Tarcı́lia Aparecida; Teixeira, Antônio Lúcio

doi:10.1159/000367714

Cited by 40 publications

(65 citation statements)

References 33 publications

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“…Agha‐Hosseini et al reported that the severity of dry mouth was inversely correlated with whole salivary 17β‐oestradiol concentration and positively correlated with whole salivary cortisol concentration . Some studies reported elevation of levels of pro‐inflammatory cytokines in saliva including IL‐2, IL‐6 and TNF‐α, and decrease in the level of anti‐inflammatory cytokine IL‐10 in BMS patients when compared to controls. Authors have suggested that preclinical level of inflammation may be involved in the pathogenesis of BMS, although other studies have described no significant changes of these cytokine levels in saliva .…”

Section: Introductionmentioning

confidence: 99%

An updated review on pathophysiology and management of burning mouth syndrome with endocrinological, psychological and neuropathic perspectives

Imamura

Shinozaki

Okada-Ogawa

et al. 2019

J of Oral Rehabilitation

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Burning mouth syndrome (BMS) is a chronic oro-facial pain disorder of unknown cause. It is more common in peri-and post-menopausal women, and sex hormone dysregulation is believed to be an important causative factor. Psychosocial events often trigger or exacerbate symptoms, and persons with BMS appear to be predisposed towards anxiety and depression. Atrophy of small nerve fibres in the tongue epithelium has been reported, and potential neuropathic mechanisms for BMS are now widely investigated. Historically, BMS was thought to comprise endocrinological, psychosocial and neuropathic components. Neuroprotective steroids and glial cell line-derived neurotrophic factor family ligands may have pivotal roles in the peripheral mechanisms associated with atrophy of small nerve fibres. Denervation of chorda tympani nerve fibres that innervate fungiform buds leads to alternative trigeminal innervation, which results in dysgeusia and burning pain when eating hot foods. With regard to the central mechanism of BMS, depletion of neuroprotective steroids alters the brain network-related mood and pain modulation. Peripheral mechanistic studies support the use of topical clonazepam and capsaicin for the management of BMS, and some evidence supports the use of cognitive behavioural therapy. Hormone replacement therapy may address the causes of BMS, although adverse effects prevent its use as a first-line treatment. Selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs) may have important benefits, and well-designed controlled studies are expected. Other treatment options to be investigated include brain stimulation and TSPO (translocator protein 18 kDa) ligands. K E Y W O R D Sburning mouth syndrome, central pain modulation, menopause, neuroprotective steroids | 575 IMAMURA et Al. | INTRODUC TI ONBurning mouth symptoms that occurred as secondary phenomena attributable to local conditions 1-9 were previously referred to as "secondary" burning mouth syndrome (BMS), 10 but BMS now refers only to burning symptoms not attributable to local or systemic causes. 11 After excluding such conditions, some common characteristics of BMS are important. Burning sensations are usually bilateral, and intensity fluctuates. 2 The most common site is the tip of the tongue, but pain is often noted at the lateral border of the tongue, lips and hard palate. 12 Affected persons often complain of dysgeusia, 13 which may be accompanied by subjective xerostomia. 14 Peri-and post-menopausal women are predisposed to the condition.Some patients exhibit depressive symptoms and anxiety 15-18 and may express concern regarding the presence of a malignant condition. 10,16 Psychosocial stressors can trigger or worsen pain, 15,19 while eating and drinking usually alleviate pain. 10,20 These manifestations are characteristic features of BMS and should not be excluded as secondary signs or symptoms of primary disease. Agreement on these clinical features yields important clues in understanding the underlying pathoph...

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Section: Introductionmentioning

confidence: 99%

An updated review on pathophysiology and management of burning mouth syndrome with endocrinological, psychological and neuropathic perspectives

Imamura

Shinozaki

Okada-Ogawa

et al. 2019

J of Oral Rehabilitation

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“…Subsequent processing included dilution of saliva (1:1) in a PBS solution (0.4 mM NaCl and 10 mM NaPO 4) containing 0.05% Tween‐20 and inhibitors of protease (EDTA and 0.01 mg/ml aprotinin). The solution was homogenized, distributed in aliquots, and frozen at −20°C until analysis . For each assay, saliva was processed according to the protocol indicated by the manufacturer of the ELISA kits.…”

Section: Methodsmentioning

confidence: 99%

Cell phone use is associated with an inflammatory cytokine profile of parotid gland saliva

Siqueira

Souza

Ferreira

et al. 2016

J Oral Pathology Medicine

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“…Using saliva biomarkers in BMS patients, one study demonstrated a mild negative correlation between levels of cortisol I and interleukin-6 (IL-6) and the predisposition to face new challenges, in what could be attributed to stress 46 . In addition, statistically high salivary levels of IL-2 and Il-6 that could be associated with the severity of BMS suggest that these markers indicate the existence of an inflammatory and immunologic mechanism behind its etiology 47 .…”

Section: Saliva Changesmentioning

confidence: 99%

“…BMS patients have higher anxiety and depression scores. Also, it is widely accepted that pain is a somatic aspect of depression and anxiety worsens somatization [99][100][101][102][103][104][105][106][107][108][109][110][111][112][113] . Psychological conditions may play an important role in the modulation of pain perception.…”

Section: Psychogenic Causesmentioning

confidence: 99%

Burning Mouth Syndrome –Latest update

Tomattis¹,

Munerato²

2016

Int J Dentistry Res

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Introduction: Burning mouth syndrome (BMS) is characterized by a recurrent daily burning sensation with no evidence lesions in the oral mucosa. It is accompanied by subjective dry mouth and dysgeusia. The tongue is the most commonly affected site, but the condition also affects other sites in the mouth. Its etiopathogeny is multifactorial and its diagnosis is made by exclusion. Objective: This article reviews the literature about the epidemiology, etiopathogeny, and diagnosis of BMS in the past 15 years. Articles were selected from PubMed/MEDLINE, and included clinical assays, case reports, and reviews. We found 509 articles, and only 136 were chosen. The key words were: burning mouth syndrome (BMS), review, etiopathogeny, diagnosis. Conclusions: BMS remains an important diagnostic challenge, though the disease is considered a neuropathy characterized by damage to trigeminal peripheral nervous fibers, which triggers central sensitization. In addition to BMS and secondary BMS, it seems relevant to include complicated BMS, in which symptoms persist despite the elimination of local and systemic causes. BMS should be investigated by a transdisciplinary team that will take into account all aspects active in the mental and physical dimensions of the condition, in the most detailed way. Therefore, QST, imaging investigations, various evaluation scales of mental health and of the impact of BMS on quality of life as well as the investigation of sleep disorders and changes in circadian rhythm could be useful tools in the development of treatment strategies based on findings and observing the characteristics of each BMS patient in light of specifics of diagnosis.

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The Association of Openness Personality Trait with Stress-Related Salivary Biomarkers in Burning Mouth Syndrome

Cited by 40 publications

References 33 publications

An updated review on pathophysiology and management of burning mouth syndrome with endocrinological, psychological and neuropathic perspectives

An updated review on pathophysiology and management of burning mouth syndrome with endocrinological, psychological and neuropathic perspectives

Cell phone use is associated with an inflammatory cytokine profile of parotid gland saliva

Burning Mouth Syndrome –Latest update

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