The association of oesophagitis with disease in the stomach and duodenum

Bateson, M. C.; Bouchier, I. A. D.

doi:10.1136/pgmj.57.666.217

Cited by 12 publications

(2 citation statements)

References 4 publications

(4 reference statements)

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“…It should be remembered however, that a variable proportion of peptic ulcer patients have coexistent GERD 46 ‐ 49 and the phenomenon of new GERD after H. pylori cure could be explained, at least in part, by the unmasking of pre‐existent disease. In a study where the endoscopic grade of GERD was systematically recorded before eradication therapy in 244 H. pylori ‐positive peptic ulcer patients, 49 (20%) had GERD, which tended to improve or remain stable in the short term after H. pylori therapy 50 .…”

Section: Gerd and H Pylori Curementioning

confidence: 99%

Review article:Helicobacter pyloriand gastro‐oesophageal reflux disease—clinical implications and management

1999

Aliment Pharmacol Ther

129

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A significant proportion of patients with gastro‐oesophageal reflux disease (GERD) have Helicobacter pylori infection, but it is unclear whether or not H. pylori should be treated in this clinical setting. The aim of this review was to critically assess the relationship between H. pylori and GERD and its potential implications for the management of GERD. Data for this review were gathered from the following sources up to April 1998—the biomedical database M EDLINE, a detailed review of medical journals, and a review of abstracts submitted to relevant international meetings. On average, 40% of GERD patients carry H. pylori infection, with a reported infection prevalence ranging from 16% to 88%. To date, there has been no reported controlled trial of effective H. pylori therapy in GERD. GERD has been reported to develop de novo following the cure of H. pylori in peptic ulcer disease. In the presence of H. pylori, proton pump inhibitor therapy appears to accelerate the development of atrophic corpus gastritis, a potentially precancerous condition. Conversely, proton pump inhibitor therapy seems to become less effective after cure of H. pylori. The mechanisms underlying these important contrasting phenomena are poorly understood. The relationship between H. pylori and GERD is complex, and it is difficult to give definitive guidelines on the management of H. pylori infection in GERD. Controlled trials of H. pylori therapy in GERD are urgently needed, as well as further long‐term data on both the natural history of gastric histopathological changes in the H. pylori‐positive GERD patient treated with proton pump inhibitors, and the impact of H. pylori status on the clinical efficacy of antisecretory therapy. Pending these data, it is perhaps advisable to advocate cure of H. pylori in young patients with proton pump inhibitor‐dependent GERD who, in the absence of anti‐reflux surgery, are faced with the likelihood of long‐term medical therapy.

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Section: Gerd and H Pylori Curementioning

confidence: 99%

Review article:Helicobacter pyloriand gastro‐oesophageal reflux disease—clinical implications and management

1999

Aliment Pharmacol Ther

129

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“…It should also be noted that GERD and peptic ulcer disease can coexist (40)(41)(42) and the phenomenon of 'new' GERD after H. pylori eradication could be explained, at least in part, by unmasking of coexistent disease. We found coexistent GERD in one-fth of our H. pylori-positive peptic ulcer patients which tended to improve or remain stable after H. pylori therapy ( ulcer patients and found the 23 patients who developed GERD after eradicating H. pylori had signi cantly higher baseline GERD symptom scores than the 47 patients who did not develop GERD, again suggesting the presence of pre-existent GERD (46).…”

Section: Arguments For Eradicating H Pylorimentioning

confidence: 99%