The association of night-time systolic blood pressure with ultrasound markers of subclinical cardiac and vascular disease

O’Flynn, Anne Marie; Ho, Emily; Curtin, Ronan J.; Kearney, Patricia M.

doi:10.1097/mbp.0000000000000223

Cited by 8 publications

(10 citation statements)

References 59 publications

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“…Three studies (17,19,23) with 2,732 subjects exhibited hypertension has higher risk of increased CIMT (OR =2.60, 95% CI: 1.33-5.08, I 2 =84%, P<0.01) (Figure S2). Additionally, it was indicated that the risk of plaque was significantly greater in people with increased systolic blood pressure (SBP) variability (every 10 mmHg increase) and diastolic blood pressure (DBP) variability (1,24,25). Pulse pressure (PP) variability (every 10 mmHg increase) raises the risk of carotid plaque for both community-based subjects and stroke patients (26,27).…”

Section: Blood Pressurementioning

confidence: 99%

“…Seven studies (16,(21)(22)(23)(24)28,29) with 16,752 patients were included in the meta-analysis (Figure 2). The results showed that diabetics might have carotid plaque than non-diabetics (OR =1.31, 95% CI: 1.13-1.53, I 2 =0%, P=0.74) (Figure S3).…”

Section: Diabetes Mellitusmentioning

confidence: 99%

“…The meta-analysis of ten studies (16,(21)(22)(23)(24)28,(30)(31)(32)(33) including 12,568 patients showed that patients with hyperlipidemia (OR =1.92, 95% CI: 1.39-2.65, I 2 =0, P=0.56), hypertriglyceridemia (triglyceride ≥1.7 mmol/L) (OR =1.33, 95% CI: 1.14-1.55, I 2 =0%, P=0.85), and higher low density lipoprotein (low density lipoprotein ≥3.4 mmol/L) (OR =1.11, 95% CI: 1.08-1.13, I 2 =0%, P=0.46) were more likely to have carotid plaque (Figures S4,S5,S6). Moreover, there was strong likelihood of positive relationship between lower high density lipoprotein (high density lipoprotein ≤1.0 mmol/L) (OR =1.28, 95% CI: 0.99-1.67, I 2 =32%, P=0.22) or hypercholesterolemia (total cholesterol ≥5.2 mmol/L) (OR =1.20, 95% CI: 0.80-1.82, I 2 =6%, P=0.34) with carotid plaque (Figures S7,S8).…”

Section: Dyslipidemiamentioning

confidence: 99%

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Modifiable risk factors for carotid atherosclerosis: a meta-analysis and systematic review

Ji¹,

Leng²,

Dong³

et al. 2019

Ann. Transl. Med.

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Background: Carotid atherosclerosis is a major cause of stroke, but the conclusion about risk factors for carotid atherosclerosis is still controversial. The aim of our present meta-analysis and systematic review was to explore the modifiable risk factors for carotid atherosclerosis. Methods:We searched PubMed from January 1962 to October 2018 to include longitudinal and crosssectional studies. The results were pooled using random effects model. Heterogeneity was measured by I 2 statistic and publication bias was assessed by funnel plots.Results: A total of 14,700 articles were screened, of which 76 with 27 factors were eligible. Our metaanalysis of cross-sectional studies indicated nine factors (hyperlipidemia, hyperhomocysteinemia, hypertension, hyperuricemia, smoking, metabolic syndrome, hypertriglyceridemia, diabetes, and higher low density lipoprotein) were significantly associated with the presence of carotid plaque, among which four (hyperlipidemia, hyperhomocysteinemia, hypertension, and hyperuricemia) could elevate the risk of atherosclerosis by at least 50%; and one factor (hypertension) was associated with increased carotid intimamedia thickness. In the systematic review, another five factors [negative emotion, socioeconomic strain, alcohol, air pollution, and obstructive sleep apnea syndrome (OSAS)] were also related to the presence of atherosclerosis. The cross-sectional associations with most of the above 14 factors were further confirmed by longitudinal studies. Among them, the managements of 4 factors (hypertension, hyperlipidemia, diabetes and OSAS) were indicated to prevent carotid atherosclerosis by cohort studies.Conclusions: Effective interventions targeting pre-existing disease, negative emotion, lifestyle and diet may reduce the risk of carotid atherosclerosis. Further good-quality prospective studies are needed to confirm these findings.

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Section: Blood Pressurementioning

confidence: 99%

Section: Diabetes Mellitusmentioning

confidence: 99%

Section: Dyslipidemiamentioning

confidence: 99%

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Modifiable risk factors for carotid atherosclerosis: a meta-analysis and systematic review

Ji¹,

Leng²,

Dong³

et al. 2019

Ann. Transl. Med.

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“…Wang et al have reported that nocturnal systolic hypertension is an independent risk factor for target organ damage in patients with chronic kidney disease. O’Flynn et al demonstrate there is an association between nocturnal systolic hypertension and subclinical LV systolic dysfunction (β coefficient 0.85 for every 10 mm Hg increase, 95% CI: 0.3‐1.4). They also found nocturnal systolic BP was markedly associated with LV mass as compared to daytime systolic BP .…”

Section: Discussionmentioning

confidence: 99%

“…O’Flynn et al demonstrate there is an association between nocturnal systolic hypertension and subclinical LV systolic dysfunction (β coefficient 0.85 for every 10 mm Hg increase, 95% CI: 0.3‐1.4). They also found nocturnal systolic BP was markedly associated with LV mass as compared to daytime systolic BP . Similar to their findings, our study demonstrated that IVS thickness was significantly larger in the nocturnal systolic and systolic/diastolic groups than in the nocturnal diastolic group, while LA dimension was significantly larger in the systolic/diastolic group than in the nocturnal diastolic group.…”

Section: Discussionmentioning

confidence: 99%

Nocturnal systolic hypertension is a risk factor for cardiac damage in the untreated masked hypertensive patients

Cao

Liu

et al. 2019

J of Clinical Hypertension

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The nocturnal blood pressure (BP) has been identified as a prognostic factor for cardiovascular events. This study aimed to investigate the association between different patterns of nocturnal masked hypertension (MH) and the echocardiographic parameters in the untreated nocturnal MH patients. A total of 721 untreated MH patients (309 females and 412 males, mean age = 56.59 ± 15.20 years) from June 2006 and June 2016 were included and divided into nocturnal systolic MH (n = 77), nocturnal diastolic MH (n = 232), and nocturnal systolic/diastolic MH (n = 412) groups according to the ambulatory blood pressure monitoring. Baseline characteristics, office BP values, ambulatory BP monitoring parameters, and echocardiographic parameters were compared among the three groups. The independent factors associated with echocardiographic parameters were analyzed by multivariate linear regression. The nocturnal systolic group had the highest ratio of males, mean age, and office systolic BP (SBP), and the lowest office, 24‐hour, daytime, nocturnal diastolic BP and heart rate among the three groups. The nocturnal diastolic group had the lowest interventricular septum (IVS) thickness, left atrium (LA) dimension, and left ventricular (LV) mass among the three groups. Multivariate linear regression analysis revealed that 24‐hour, daytime, and nocturnal SBPs were all positively associated with LA dimension, IVS thickness, and LV mass (all B were positive and P < .050). Pearson's correlation analysis showed that nocturnal SBP was positively correlated with LA dimension, IVS thickness, and LV mass. These results suggested that different patterns of nocturnal MH had different echocardiographic outcomes. Nocturnal SBP was the independent factor associated with the echocardiographic parameters.

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Association Between Short-Term Systolic Blood Pressure Variability and Carotid Intima-Media Thickness in ELSA-Brasil Baseline

Ribeiro

Lotufo

Fujita

et al. 2017

American Journal of Hypertension

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The association of night-time systolic blood pressure with ultrasound markers of subclinical cardiac and vascular disease

Abstract: Supplemental Digital Content is available in the text.

Cited by 8 publications

References 59 publications

Modifiable risk factors for carotid atherosclerosis: a meta-analysis and systematic review

Modifiable risk factors for carotid atherosclerosis: a meta-analysis and systematic review

Nocturnal systolic hypertension is a risk factor for cardiac damage in the untreated masked hypertensive patients

Association Between Short-Term Systolic Blood Pressure Variability and Carotid Intima-Media Thickness in ELSA-Brasil Baseline

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