The Association of Newly Identified Respiratory Viruses with Lower Respiratory Tract Infections in Korean Children, 2000–2005

Choi, Eun Hwa; Lee, Hoan Jong; Kim, Sun Jung; Eun, Byung Wook; Kim, Nam Hee; Lee, Jin A; Lee, Jun Ho; Song, Eun Kyung; Park, So Hee Kim Ji Yong; Sung, Jae Kyu

doi:10.1086/506350

Cited by 333 publications

(386 citation statements)

References 39 publications

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“…However, our results show that LRTI associated with viral co-infection does not result in a higher incidence of severe syndromes compared to infection with HRV alone. Other groups have reported similar results (Williams et al 2004, Choi et al 2006, Calvo et al 2007, Louie et al 2009). …”

Section: Discussionsupporting

confidence: 68%

“…Due to advances in nucleic acid amplification, we can now detect HRV and determine when HRV is the causative agent of lower respiratory tract illness (LRTI) (Choi et al 2006, Miller et al 2007, Gerna et al 2009, Louie et al 2009). HRV is frequently detected in children diagnosed with bronchiolitis and pneumonia (Manoha et al 2007, Miller et al 2007, Louie et al 2009).…”

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confidence: 99%

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Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

Paula

Carneiro

Yokosawa

et al. 2011

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 68%

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confidence: 99%

Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

Paula

Carneiro

Yokosawa

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…1). Previous studies detected HBoV mainly in children less than 5 years old and mostly in infants less than 2 years old (Choi et al, 2006;Kaplan et al, 2006;Kesebir et al, 2006;Kleines et al, 2007;Brieu et al, 2008;Canducci et al, 2008;Cilla et al, 2008). However, a recent report (Guido et al, 2011) and the present work confirm that HBoV1 is also a frequent virus in adults with respiratory disease.…”

Section: Resultscontrasting

confidence: 46%

High frequency of human bocavirus 1 DNA in infants and adults with lower acute respiratory infection

Ghietto

Cámara

et al. 2012

Journal of Medical Microbiology

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Instituto de Virología 'Dr J. M. Vanella', Facultad de Ciencias Mé dicas, Universidad Nacional de Có rdoba, ArgentinaHuman bocavirus (HBoV) is a parvovirus with a possible aetiological role in respiratory disease that is currently under investigation. We detected HBoV1 in children and adults hospitalized with acute disease of the lower respiratory tract. HBoV genome was detected by PCR in nasopharyngeal swabs collected from 75 patients aged 0-89 years during 2010. HBoV was found in 17/75 (22.7 %) patients, 64.7 % of them infants younger than 1 year old and 29.4 % adults older than 30 years [the bimodal age distribution among HBoV-positive (HBoV + ) patients was statistically significant, P,0.001]. Of all HBoV + cases, 35.3 % were co-infected; all coinfections occurred in children (¡13 years old) and 83.3 % of them were HBoV-respiratory syncytial virus (RSV) co-infections. Among infants younger than 1 year, 50 % HBoV + specimens were co-infected, all of them with RSV. The rate of co-infection in infants was significantly higher compared to the frequency of co-infection in the whole cohort (P50.003). The results suggest that HBoV1 is involved in acute respiratory disease. Interplay between HBoV1 and RSV cannot be discarded as a cause of elevated percentages of co-detections in infants. INTRODUCTIONHuman bocavirus (HBoV) is a parvovirus first identified in 2005 in nasopharyngeal aspirates of children with lower respiratory tract infection (Allander et al., 2005). Since then, it has been associated with upper and lower acute respiratory infection (ARI), a leading cause of acute illnesses worldwide and the most important cause of mortality in infants and young children and disabilityadjusted life-years lost in developing countries (Simoes et al., 2006; WHO, 2009). To date, four species of HBoV have been proposed, and the name human bocavirus 1 (HBoV1) was suggested for the originally discovered virus. HBoV1 is linked to respiratory disease, while it is believed that HBoV2-4 are associated with gastroenteritis (Kapoor et al., 2010). With a ubiquitous distribution, the presence of HBoV DNA has been reported mostly in children with ARI in a variable range from 1.5 to 19 % (Allander, 2008), although recently even higher prevalence (33 %) has been observed in ill children (Martin et al., 2010). Although the virus is associated with ARI, the elevated rates of coinfection with other respiratory viruses with well-established pathogenic potential (Kaplan et al., 2006;Allander et al., 2007;Fry et al., 2007; Gerna et al., 2007;Kleines et al., 2007; Christensen et al., 2008 Christensen et al., , 2010Cilla et al., 2008;Pilger et al., 2011), the detection in asymptomatic individuals (Christensen et al., 2010) and the possibility of a persistent infection (Martin et al., 2010) make it difficult to allocate a causative role for HBoV in respiratory disease. Not only is the aetiological capacity of HBoV under investigation, but the natural history of the infection is still unknown. In addition, the impact of HBoV on the global epid...

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“…In patients, diagnosed with ARI the most frequently detected virus was HRV -33 (16.75%) ( Table 3). (8)(9)(10)(11)(12). Coinfections in this study were identified in a relatively small percentage of cases (3.15%).…”

Section: Clinical Characteristicsmentioning

confidence: 54%

Viral etiology of acute respiratory infections among children under 5 years of age in Bulgaria, during the 2013/2014 and 2014/2015 seasons

Georgieva¹,

Angelova²,

Korsun³

2015

TJS

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PURPOSE: A wide range of different viruses cause respiratory tract diseases of varying severity. This study aims to determinate the contribution of nine different viral pathogens in cases of acute respiratory infections (ARI) in children aged less than 5 years, during the 2013/2014 and 2014/2015 winter seasons in Bulgaria. METHODS: A total of 412 nasopharyngeal swabs of children under the age of 5 were tested. Children were either outpatient, or hospitalized for influenza-like illness. The clinical samples were tested for Orthomyxoviruses (influenza A/B), Paramyxoviruses (respiratory-syncytial virus -RSV; human metapneumovirus -HMPV; human parainfluenza viruses -HPIV, type 1/2/3) and human rhinoviruses (HRV) using Real Time RT-PCR reactions based on specific primers/probe. RESULTS: Virus infections were confirmed in 258 (62.6%) samples. In 107 (26%) of samples influenza viruses were detected. All of the 306 influenza virus negative patients were analyzed for Paramyxo-and Rhinoviruses. Detection rate for RSV, HMPV, HPIV1/2/3 and HRV was 19%, 5.9%, 2%, 1.3%, 3.3% and 14.1%, respectively. CONCLUSION: The present study is the first one in Bulgaria which analyzes the participation of nine different viral pathogens in the etiology of ARI among children below the age of 5 years. The study reveals the leading role of influenza viruses, RSV and rhinoviruses in the development of serious respiratory diseases in early childhood.

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The Association of Newly Identified Respiratory Viruses with Lower Respiratory Tract Infections in Korean Children, 2000–2005

Abstract: This study describes the features of LRTIs associated with newly identified viruses in children, compared with those associated with known viruses. Additional investigations are required to define the role of HBoV in LRTI.

Cited by 333 publications

References 39 publications

Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

High frequency of human bocavirus 1 DNA in infants and adults with lower acute respiratory infection

Viral etiology of acute respiratory infections among children under 5 years of age in Bulgaria, during the 2013/2014 and 2014/2015 seasons

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