The association of MIND diet with cognitive resilience to neuropathologies

Wagner, M.; Agarwal, Puja; Leurgans, Sue E.; Bennett, David A.; Schneider, Julie A.; Capuano, Ana W.; Grodstein, Francine

doi:10.1002/alz.12982

Cited by 13 publications

(3 citation statements)

References 69 publications

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“…reported a significant negative correlation between green leafy vegetables and AD pathology. [ 15 ] A low‐fat diet or a modified Mediterranean ketogenic diet for 6 weeks can benefit adults with mild cognitive impairment. [ 16 ] González‐Domínguez et al revealed that the level of Trp from AD and mild cognitive impairment patients was decreased.…”

Section: Discussionmentioning

confidence: 99%

A High‐Tryptophan Diet Alleviated Cognitive Impairment and Neuroinflammation in APP/PS1 Mice through Activating Aryl Hydrocarbon Receptor via the Regulation of Gut Microbiota

Pan,

Zhang,

et al. 2023

Molecular Nutrition Food Res

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ScopeRecent studies have highlighted the vital role of gut microbiota in the pathogenesis of Alzheimer's disease (AD). However, the effect of the regulation of gut microbiota by dietary components on AD remains unknown. Thus, the study explored that a high‐tryptophan (Trp) diet alleviates cognitive impairment by regulating microbiota.Methods and resultsMale APP/PS1 mice are fed 0.5% Trp diet for 4 weeks, and then cognitive function, amyloid‐β (Aβ) deposition, microglial activation, proinflammatory cytokines production, and gut microbiota are detected. Moreover, the level of aryl hydrocarbon receptor (AhR) and NF‐κB pathway related protein are determined. The results show that high‐Trp diet significantly alleviates cognitive impairment and Aβ deposits. Moreover, high‐Trp diet significantly inhibits activation of microglia, decreases the level of cluster of differentiation 11b (CD11b), and restrains the activation markers of microglia, such as cyclooxygenase‐2 (Cox‐2), interleukin (IL)‐1β, and IL‐6. Notably, high‐Trp diet significantly activates AhR, inhibits the phosphorylation of p65, and improves microbiota dysbiosis.ConclusionsThese findings demonstrated that high‐Trp diet exerts anti‐inflammatory effects via upregulating AhR and suppressing NF‐κB pathway, and its mechanisms may be mediated by regulating gut microbiota, suggesting that Trp diet may be a potential strategy for AD intervention.

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Section: Discussionmentioning

confidence: 99%

A High‐Tryptophan Diet Alleviated Cognitive Impairment and Neuroinflammation in APP/PS1 Mice through Activating Aryl Hydrocarbon Receptor via the Regulation of Gut Microbiota

Pan,

Zhang,

et al. 2023

Molecular Nutrition Food Res

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“…Over a 9-year follow-up, the Rush Memory and Aging Project showed that adherence to the MIND diet was associated with higher cognitive levels and slower rates of cognitive decline, after controlling for neuropathology. Overall MIND score was more strongly related to cognitive outcomes than the individual food components [11]. Meta-analysis of cohorts showed that 1 SD increment of the MIND score was associated with 0.042 units higher in global cognitive function z score and 0.010 units slower in annual cognitive decline [12 ▪ ].…”

Section: Diet and Cognitionmentioning

confidence: 99%

Composition of healthy diets for older persons

Yeung

Kwan

Woo

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review This study aims to review recent evidence (2022–2023) on the role of diet in promoting healthy aging in older adults. Recent findings Current evidence of diet and healthy aging is limited to epidemiological studies. A healthy diet is beneficial for individual domains of intrinsic capacity, that is, cognition, locomotion, vitality, psychological, and/or sensory functions, with sex-specific differences reported. Only a few studies used the multidimensional concept of intrinsic capacity as an outcome. This review supports that a healthy diet for older adults consists of plenty of plant-based foods, adequate protein-rich foods, and healthy fats. Next to quantity, improving the quality and variety within food groups play a role in optimizing health. Data on the associations between adherence to national food-based dietary guidelines and intrinsic capacity are scarce. Summary A healthy diet, centered on plant-based foods, adequate protein-rich foods and healthy fats, potentially promotes healthy aging. Future studies may evaluate the association between adherence to healthy dietary patterns (particularly national food-based dietary guidelines) and the multidimensional concept of intrinsic capacity, with consideration of sex-specific differences. Clinical trials are warranted to inform the causal effects of diet and outcomes related to intrinsic capacity.

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“…It prioritizes plants, nuts, berries, fish, and olive oil, all known for their potential cognitive benefits. [ 21 , 22 , 23 ] Research increasingly suggests that specific diets and nutrients may delay Alzheimer's‐related cognitive decline. [ 24 , 25 ] However, the complex mechanisms of the brain that are affected remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Deep Learning‐Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease

Li,

Sun,

Zhou

et al. 2024

Advanced Science

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Alzheimer's disease (AD) is a pressing concern in neurodegenerative research. To address the challenges in AD drug development, especially those targeting Aβ, this study uses deep learning and a pharmacological approach to elucidate the potential of pyrroloquinoline quinone (PQQ) as a neuroprotective agent for AD. Using deep learning for a comprehensive molecular dataset, blood–brain barrier (BBB) permeability is predicted and the anti‐inflammatory and antioxidative properties of compounds are evaluated. PQQ, identified in the Mediterranean‐DASH intervention for a diet that delays neurodegeneration, shows notable BBB permeability and low toxicity. In vivo tests conducted on an Aβ₁₋₄₂‐induced AD mouse model verify the effectiveness of PQQ in reducing cognitive deficits. PQQ modulates genes vital for synapse and anti‐neuronal death, reduces reactive oxygen species production, and influences the SIRT1 and CREB pathways, suggesting key molecular mechanisms underlying its neuroprotective effects. This study can serve as a basis for future studies on integrating deep learning with pharmacological research and drug discovery.

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The association of MIND diet with cognitive resilience to neuropathologies

Cited by 13 publications

References 69 publications

A High‐Tryptophan Diet Alleviated Cognitive Impairment and Neuroinflammation in APP/PS1 Mice through Activating Aryl Hydrocarbon Receptor via the Regulation of Gut Microbiota

A High‐Tryptophan Diet Alleviated Cognitive Impairment and Neuroinflammation in APP/PS1 Mice through Activating Aryl Hydrocarbon Receptor via the Regulation of Gut Microbiota

Composition of healthy diets for older persons

Deep Learning‐Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease

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