The Association of Microalbuminuria With Aortic Stiffness Is Independent of C-Reactive Protein in Essential Hypertension

Abstract

Our results suggest that in patients with essential hypertension, MAU and CRP are independently associated with an increased aortic stiffness.

Aortic Pulse Wave Velocity Is Associated With Measures of Subclinical Target Organ Damage

“…Moreover, most participants did not have significant renal dysfunction (mean estimated glomerular filtration rate 65.4 ml/min/1.73 m 2 ). Differently from our study, an association between the UACR and arterial stiffness was reported in previous studies that included mainly diabetic patients (38) or untreated hypertensive patients (8,11,36). …”

“…Although an association between arterial stiffness and microalbuminuria was previously reported (8,11,35,36), we were unable to confirm this in our study. Because a reduction in aPWV resulting from antihypertensive treatment has been shown to decrease the UACR (37), the lack of association may be because the participants in our study had a low UACR (mean = 8.2 mg/g, normal <30 mg/g), their blood pressure was, in general, well controlled, and nearly a third of participants were being treated with either angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, drugs known to decrease microalbuminuria.…”

“…Although previous studies assessed the associations of arterial stiffness with arteriosclerosis (8-12), most were limited to 1 or 2 measures of target organ damage. Furthermore, a significant proportion of the available studies included only untreated hypertensive subjects.…”

Fatores associados ao aumento no índice de incremento de pressão radial em indivíduos hipertensos

“…Previous studies exploring similar issues 7,21 analyzed a sample size similar to this study. Descriptive analysis was performed for qualitative variables and quantitative results are presented as mean ± standard deviations.…”

“…It is well recognized that arterial stiffness parameters predict clinical outcomes, such as coronary artery disease 5,6 , stroke 6 , urinary albumin excretion 7,8 , progression of chronic kidney disease 9 , survival in end-stage renal disease 10 and general cardiovascular risk 11 . The current standard for assessing this condition involves the measurement of several variables by noninvasive applanation tonometry, including the radial augmentation index (r-AI) 12 .…”