The Association of Methylation in the Promoter of APC and MGMT and the Prognosis of Taiwanese CRC Patients

Abstract

Methylation in the APC promoter may serve as a predictor for the prognosis of Taiwanese CRC patients.

Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens

“…16 APC hypermethylation is also frequent in sporadic CRC and may cause transcriptional silencing occurring early during colon neoplasia progression, but the reported methylation status of the APC promoter varies greatly among studies performed in different populations. [16][17][18][19] Moreover, hypermethylation of the APC promoter has been shown to be relatively common in the normal colonic mucosa. 19 Present results are in agreement with recent reports in Swedish and Vietnamese CRC patients, where methylation of the APC gene was detected with similar frequencies between the cancerous and normal tissues.…”

Analysis of APC and IGFBP7 promoter gene methylation in Swedish and Vietnamese colorectal cancer patients

“…The reported methylation status of the promoter of APC varies greatly among studies of CRC in different populations (16)(17)(18)(19)(20). Moreover, hypermethylation of the APC promoter has been shown to be relatively common in other gastrointestinal neoplasms, including those of the stomach, liver, pancreas and oesophagus (17,29).…”

“…The APC promoter methylation rate has been detected in CRC and normal colorectal mucosa at a range of 11 to 62% in different populations, and has been suggested to moderate the Wnt signalling pathway (16)(17)(18)(19)(20). Studies have indicated that IGFBP7 is inactivated by DNA methylation in human colon, lung and breast cancer (21)(22)(23).…”

Methylation status of the APC and RASSF1A promoter in cell-free circulating DNA and its prognostic role in patients with colorectal cancer

“…Loss of APC function results in nuclear accumulation of β-catenin, which leads to the transcriptional activation (via the β-catenin/T-cell factor complex) of target genes that may contribute to colorectal tumorigenesis (23,24). The rate of APC promoter methylation in CRC and normal colorectal mucosa has been reported to range from 11 to 62% in different populations, and has been suggested to moderate the Wnt signaling pathway (25)(26)(27)(28)(29). Furthermore, hypermethylation of the APC promoter has been demonstrated to be relatively common in other gastrointestinal neoplasms, including those of the stomach, liver, pancreas and oesophagus (30).…”