The association of metabolic syndrome and aging with cognition in Asian men

Goh, Victor Hng Hang; Hart, W. G.

doi:10.3109/13685538.2014.968772

Cited by 9 publications

(6 citation statements)

References 50 publications

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“…Increased TG levels after the intake of fat or refined sugars have been associated with impaired spatial memory in young male rats (42) and minipigs (43). These animal studies support findings in elderly people showing negative associations between TG levels and cognitive abilities (44,45). It is thus possible that the memory improvements found in our study were mediated by reduced blood TG levels during testing.…”

Section: Discussionsupporting

confidence: 91%

Prenatal, but not early postnatal, exposure to a Western diet improves spatial memory of pigs later in life and is paired with changes in maternal prepartum blood lipid levels

et al. 2016

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Maternal obesity and perinatal high‐fat diets are known to affect cognitive development. We examined the effects of late prenatal and/or early postnatal exposure to a Western‐type diet, high in both fat and refined sugar, on the cognition of pigs (Sus scrofa) in the absence of obesity. Thirty‐six sows and their offspring were assigned to 1 of 4 treatments in a 2 × 2 factorial arrangement, with 8 wk prenatal and 8 wk postnatal exposure to a Western diet (enriched in fat, sucrose, and cholesterol) or control diets as factors. Compared to controls, piglets exposed to the prenatal Western diet showed enhanced working and reference memory during the acquisition and reversal phases of a spatial hole‐board task. Mothers fed the prenatal Western diet had higher prepartum blood cholesterol and free fatty acid levels. Postnatal exposure to the Western diet did not affect piglet cognitive performance, but it did increase postpartum maternal and postweaning piglet cholesterol levels. The Western diet had no effect on maternal or offspring insulin sensitivity or leptin levels. In conclusion, a prenatal Western diet improved memory function in pigs, which was paired with changes in prepartum maternal blood cholesterol levels. These findings highlight the key role of late fetal nutrition for long‐term programming of cognition.—Clouard, C., Kemp, B., Val‐Laillet, D., Gerrits, W. J. J., Bartels, A. C., Bolhuis, J. E. Prenatal, but not early postnatal, exposure to a Western diet improves spatial memory of pigs later in life and is paired with changes in maternal prepartum blood lipid levels. FASEB J. 30, 2466‐2475 (2016). http://www.fasebj.org

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Section: Discussionsupporting

confidence: 91%

Prenatal, but not early postnatal, exposure to a Western diet improves spatial memory of pigs later in life and is paired with changes in maternal prepartum blood lipid levels

et al. 2016

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“…Overman et al (2017) found no evidence of a relationship between MetS and memory impairment. Harrison et al (2015) did not find a significant relationship between MetS and memory, these findings being consistent with those of Goh and Hart (2014), Lai et al (2014), and Levin et al (2014). Despite finding a relationship between high blood pressure and other cognitive domains, particularly concerning memory, they did not find significant data.…”

Section: Cognitive Domain: Memorysupporting

confidence: 59%

Neuropsychology of metabolic syndrome: A systematic review and meta-analysis

et al. 2021

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There is growing evidence of the relationship between Metabolic Syndrome (MetS) and cognitive decline; however, this has not been conclusively established yet. This systematic review and meta-analysis address the most crucial cognitive performance findings, including those on global cognitive function, memory, attention, and executive functions, in adult people with MetS. Two electronic databases were searched (April-May 2020) using the terms "metabolic syndrome" and "cognition," including publications from 2010 to 2020. Thirty-six studies were found. Among these, 17 reported negative associations in cognition with MetS, mainly in terms of verbal memory and executive functions, particularly in the middle-aged population. A meta-analysis of global cognitive function revealed that the MetS group had a lower score than the control group (25.26 and 25.6, respectively, 95% CI, −0.60 to −0.12, p = 0.004). MetS is related to the enhanced presentation of cognitive impairment and its evolution into a Major Neurocognitive Disorder (MND). Further research involving longitudinal studies, including assessments with similar instruments, correctly separated by age group and education, is required.

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“… 33 Goh and Hart found high TG levels were positively associated with short-term memory in Asian men. 34 One study showed that triglycerides levels were associated with a decreased risk of Alzheimer’s disease in women. 35 Another study found that high TG levels were negatively correlated with cognitive function in female patients with major depressive disorders.…”

Section: Discussionmentioning

confidence: 99%

Correlation between serum lipid profiles and cognitive impairment in old age: a cross-sectional study

Yan

Cheng

et al. 2023

Gen Psych

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BackgroundThe correlation between cognitive function and lipid profiles, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides, is inconsistent.AimsThis cross-sectional study investigated the association between serum lipid levels and the prevalence of cognitive impairment among community-dwelling older adults and explored this difference in association by gender and urban-rural residency.MethodsParticipants aged 65 and above in urban and rural areas were recruited between 2018 and 2020, selected from the Hubei Memory and Aging Cohort Study. Detailed neuropsychological evaluations, clinical examinations and laboratory tests were conducted in community health service centres. Multivariate logistic regression was used to analyse the correlation between serum lipid profiles and the prevalence of cognitive impairment.ResultsWe identified 1 336 cognitively impaired adults (≥65 years)—1 066 with mild cognitive impairment and 270 with dementia—from 4 746 participants. Triglycerides level was correlated with cognitive impairment in the total sample (χ2=6.420, p=0.011). In gender-stratified multivariate analysis, high triglycerides in males reduced the risk of cognitive impairment (OR: 0.785, 95% CI: 0.623 to 0.989, p=0.040), and high LDL-C in females increased the risk of cognitive impairment (OR: 1.282, 95% CI: 1.040 to 1.581, p=0.020). In both gender-stratified and urban-rural stratified multivariate analyses, high triglycerides reduced the risk of cognitive impairment in older urban men (OR: 0.734, 95% CI: 0.551 to 0.977, p=0.034), and high LDL-C increased the risk of cognitive impairment in older rural women (OR: 1.830, 95% CI: 1.119 to 2.991, p=0.016).ConclusionsThere are gender and urban-rural differences in the correlation of serum lipids with cognitive impairment. High triglycerides levels may be a protective factor for cognitive function in older urban men, while high LDL-C levels may be a risk factor for cognitive function in older rural women.

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The association of metabolic syndrome and aging with cognition in Asian men

Cited by 9 publications

References 50 publications

Prenatal, but not early postnatal, exposure to a Western diet improves spatial memory of pigs later in life and is paired with changes in maternal prepartum blood lipid levels

Prenatal, but not early postnatal, exposure to a Western diet improves spatial memory of pigs later in life and is paired with changes in maternal prepartum blood lipid levels

Neuropsychology of metabolic syndrome: A systematic review and meta-analysis

Correlation between serum lipid profiles and cognitive impairment in old age: a cross-sectional study

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