The Association of Menstrual Migraine with the Premenstrual Syndrome

Facchinetti, Fabio; Neri, Isabella; Martignoni, E.; Fioroni, L.; Nappi, Giuseppe; Genazzani, Andrea R.

doi:10.1046/j.1468-2982.1993.1306422.x

Cited by 46 publications

(37 citation statements)

References 17 publications

(16 reference statements)

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“…Su et al [18]found a similar result in premenstrual syndrome patients, implying that the 5-HT system is a modulatory factor in the occurrence of menstrually related symptoms that can be associated with MM [40]. …”

Section: Discussionmentioning

confidence: 85%

Neuroendocrine Response to the Serotonin Agonist M-Chlorophenylpiperazine in Women with Menstrual Status migrainosus

et al. 2003

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To assess the neuroendocrine correlates of menstrual status migrainosus (MSM) and menstrual migraine (MM), we evaluated the prolactin (PRL) and cortisol responses to the direct central serotoninergic (5-HT) agonist meta-chlorophenylpiperazine (m-CPP) administered orally (0.5 mg/kg) during the follicular (FP: +6, +8) and luteal phases (LP: –4, –6) of the same menstrual cycle. Ten women with MSM (migraine attacks occurring within 2 days of the onset of menstrual bleeding but lasting more than 72 h) and 9 women with MM (migraine occurring within 2 days of the onset of menstrual bleeding with a typical duration of attacks) were studied. Six healthy women served as controls. Blood samples were taken at times –30, 0 and every 30 min over 4 h. Statistical analysis was performed using MANOVA followed by Duncan’s post hoc comparisons. We found that the PRL response to the m-CPP test was significantly blunted in MSM compared with MM and controls in both phases of the menstrual cycle (F = 4.6; p < 0.001). Indeed, the PRL area under the curve (AUC) after m-CPP was higher in both MM and controls compared with MSM (F = 12.7; p < 0.001). The m-CPP-induced cortisol response was absent in MSM compared with MM and controls in both FP and LP (F = 4.1; p < 0.001). On the other hand, the pattern of the plasma cortisol response to m-CPP was similar in MM and controls throughout the menstrual cycle. In addition, the basal plasma cortisol levels were significantly higher in MSM compared with controls (p < 0.001) and MM (p < 0.001) during FP, but not in LP, and progressively decreased over time. Thus, no significant effect of the menstrual cycle phase and diagnosis on the cortisol AUC was found, while a significant diagnosis effect (F = 25.6; p < 0.001) on %Δ_max plasma cortisol levels was evident and consistent with the lack of cortisol response to m-CPP in MSM during the FP and LP compared with MM and controls. A derangement in central 5-HT control of pituitary PRL, and even more so in cortisol release, is present in women with MSM, but not with MM, regardless of the phase of the menstrual cycle, suggesting the involvement of some 5-HT₁ and 5-HT₂ receptor subtypes in the occurrence of extremely severe migraine attacks triggered by menstruation.

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Section: Discussionmentioning

confidence: 85%

Neuroendocrine Response to the Serotonin Agonist M-Chlorophenylpiperazine in Women with Menstrual Status migrainosus

et al. 2003

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“…PMS associated with menstrual migraine has been evaluated and increased symptoms of PMS associated with menstrual migraine were observed [18][19][20][21][22][23][24][25]. It is therefore suggested that all women with PMS be examined for the presence of menstrual migraine using IHS criteria (International headache society) as medical and social consequences of menstrual headache affect not only the women but also their family [25].…”

Section: Discussionmentioning

confidence: 99%

“…It is therefore suggested that all women with PMS be examined for the presence of menstrual migraine using IHS criteria (International headache society) as medical and social consequences of menstrual headache affect not only the women but also their family [25]. Therefore, the diagnosis and determination of the type of headache can help use an appropriate treatment and largely solve this problem.…”

Section: Discussionmentioning

confidence: 99%

Migraine in Premenstrual Syndrome; Frequency and Associated Factor

Homam

Farajpour

Hatamian

et al. 2017

Caspian.J.Neurol.Sci

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“…Only a few research papers consider the possibility of an association between PMS and migraine [10][11][12] . However, the type of headache in PMS has not been properly characterized, allowing space for mismanagement of these headache attacks.…”

Section: Discussionmentioning

confidence: 99%

Characterization of headaches in the premenstrual tension syndrome

Fragoso

Guidoni

Castro

2009

Arq. Neuro-Psiquiatr.

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-Objective: Characterization of headaches in premenstrual syndrome (PMS). Although headache is one of the symptoms for PMS, no details on this headache are given by the American College of Obstetrics and Gynecology (ACOG) criteria. Method: A group of 45 fertile age women presenting PMS were invited to complete a registration diary for headache and PMS symptoms for three consecutive months. The diary included details of each headache attack, allowing for classification according to the International Headache Society criteria (IHS-2004). Results: Migraine without aura was the most common type of headache in PMS (n=27, 60%), followed by tension type headache (n=15, 30%). Only in two cases the type of headache varied among the observed months, and only in one case the diagnosis could not be concluded by the IHS-2004 criteria. Conclusion: Better clinical and therapeutic approach to headache in PMS can be achieved if the patient's type of headache could be properly characterized.Key wOrdS: headache, migraine, tension type headache, premenstrual tension syndrome. Caracterização das cefaléias na síndrome da tensão pré-menstrualResumo -Objetivo: Caracterização das cefaléias na síndrome da tensão pré-menstrual (TPM). embora cefaléia seja um dos sintomas associados à TPM, não são fornecidos detalhes sobre esta dor pelos critérios do American College of Obstetrics and Gynecology (ACOG). Método: Um grupo de 45 mulheres em idade fértil apresentando TPM foi convidado a preencher um diário de registro de cefaléia e dos sintomas de TPM por três meses consecutivos. O diário incluía detalhes de cada crise de cefaléia, permitindo classificação de acordo com os critérios da International Headache Society (IHS-2004). Resultados: enxaqueca sem aura foi a forma mais freqüente de cefaléia na TPM (n=27, 60%), seguida de cefaléia tipo tensional (n=15, 30%). em apenas dois casos a cefaléia variou entre os meses observados e em apenas um caso o diagnóstico não pôde ser conclusivo pelos critérios da IHS-2004. Conclusão: Melhor manejo clínico e terapêutico pode ser obtido na cefaléia da TPM se o tipo de cefaléia apresentado pela paciente puder ser adequadamente caracterizado.PAlAvrAS-CHAve: cefaléia, enxaqueca, cefaléia tipo tensional, síndrome da tensão pré-menstrual.

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The Association of Menstrual Migraine with the Premenstrual Syndrome

Cited by 46 publications

References 17 publications

Neuroendocrine Response to the Serotonin Agonist M-Chlorophenylpiperazine in Women with Menstrual Status migrainosus

Neuroendocrine Response to the Serotonin Agonist M-Chlorophenylpiperazine in Women with Menstrual Status migrainosus

Migraine in Premenstrual Syndrome; Frequency and Associated Factor

Characterization of headaches in the premenstrual tension syndrome

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