The association of lumican polymorphisms and high myopia in a Southern Chinese population

Abstract

LUM c.507 polymorphism may be a risk factor for the pathogenesis of high myopia in the Southern Chinese population.

Differential methylation of microRNA encoding genes may contribute to high myopia

“…It is a complex trait with a multifactorial etiology, including genetic and environmental factors such as near work ( Pärssinen et al, 2014 ), artificial light exposure ( Czepita et al, 2004 ), lack of activity outdoor ( Pärssinen et al, 2014 ; Xiong et al, 2017 ; Lingham et al, 2021 ), a higher level of education ( Verhoeven et al, 2013 ) and urbanization ( Czepita et al, 2008 ; Ip et al, 2008 ; Uzma et al, 2009 ) or diet with high sugar intake ( Galvis et al, 2017 ). Genetic contribution to refractive error and HM could be monogenic caused by rare mutations but is more often polygenic since a number of genomic regions, candidate genes, and sequence variants involved in HM pathogenesis have been identified ( Inamori et al, 2007 ; Han et al, 2009 ; Metlapally et al, 2010 ; Wakazono et al, 2016 ; Xiao et al, 2016 ; Wang et al, 2017 ; Napolitano et al, 2018 ; Cai et al, 2019 ; Tideman et al, 2021 ). Thus far, 27 myopia loci have been documented in Online Mendelian Inheritance in Man and we have identified three novel HM loci at 7p22.1-7p21.1, 7p12.3-7p11.2, and 12p12.3-12p12.1 in Polish patients ( Rydzanicz et al, 2011 ).…”