The Association of Long Non-Coding RNA SNHG6 Expression with Clinicopathological Features and Prognosis in Cancer

Wu, Ying; Zhang, Yijing; Zhu, Xiaoli; Liu, Hongbing

doi:10.7754/clin.lab.2019.190346

Cited by 4 publications

(4 citation statements)

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“…A high level of SNHG1 is associated with poor overall and disease-free survival in all of these malignancies (205)(206)(207). SNHG6 leads to worse prognosis and a propensity of distant metastasis formation (208).…”

Section: Future Applications Based On Current Knowledge-discussionmentioning

confidence: 99%

An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes

et al. 2020

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The small nucleolar RNA host genes (SNHGs) are a group of long non-coding RNAs, which are reported in many studies as being overexpressed in various cancers. With very few exceptions, the SNHGs (SNHG1, SNHG3, SNHG5, SNHG6, SNHG7, SNHG12, SNHG15, SNHG16, SNHG20) are recognized as inducing increased proliferation, cell cycle progression, invasion, and metastasis of cancer cells, which makes this class of transcripts a viable biomarker for cancer development and aggressiveness. Through our literature research, we also found that silencing of SNHGs through small interfering RNAs or short hairpin RNAs is very effective in both in vitro and in vivo experiments by lowering the aggressiveness of solid cancers. The knockdown of SNHG as a new cancer therapeutic option should be investigated more in the future.

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Section: Future Applications Based On Current Knowledge-discussionmentioning

confidence: 99%

An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes

et al. 2020

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“…According to recent studies, SNHG6 is overexpressed in cancer tissues compared with the corresponding noncancerous tissues as well as in different cancer cell lines [11][12][13]. Upregulated SNHG6 relates to advanced tumor progression and short survival in patients [14,15]. SNHG6 is responsible for cell proliferation, migration, invasion, reduced apoptosis in vitro, increased tumor size, and increased metastases in vivo [16,17].…”

Section: Snhg6-a Novel Player In Human Tumorsmentioning

confidence: 99%

Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors

et al. 2020

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Increased expression of the small nucleolar RNA host gene 6 (SNHG6) has been reported in different cancers, such as hepatocellular carcinoma, colorectal cancer, and lung cancer. The high expression level of SNHG6 is associated with tumor progression and poor prognosis. This paper provides an overview of recent studies on the oncogenic role and potential clinical utilities of SNHG6. Upregulated SNHG6 arrests tumor cell cycle and reduces apoptosis but promotes migration, invasion, metastasis, epithelial-mesenchymal transition (EMT), and chemoresistance in tumors. Mechanically, SNHG6 primarily sponges tumor suppressor microRNA (miRNA), functioning as a competing endogenous RNA. Once sponged, miRNA is unable to degrade, silence, or hamper the translation of its downstream, mostly oncogenic genes, ultimately driving cancer-related processes. Thus, SNHG6 might serve as a biomarker for cancer diagnosis and prognosis.

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“…15 SnoRNA host gene 6 (SNHG6), a novel lncRNA, affects the progression of a variety of tumors. 16 Studies have also shown that SNHG6 can affect the biological function of tumor cells by sponging miRNAs. [17][18][19] For example, SNHG6 enhances the chemoresistance of colorectal cancer cells to 5-fluorouracil via regulating ULK1 expression by targeting miR-26a-5p.…”

Section: Introductionmentioning

confidence: 99%

<p>LncRNA SNHG6 Inhibits Apoptosis by Regulating EZH2 Expression via the Sponging of MiR-101-3p in Esophageal Squamous-Cell Carcinoma</p>

Wang

Yang

et al. 2020

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Background: The long non-coding RNA (lncRNA) SNHG6 was significantly upregulated in esophageal squamous-cell carcinoma (ESCC), and it promoted ESCC cell proliferation, invasion, and migration. However, the effects of SNHG6 on cell apoptosis and the corresponding underlying mechanisms have not yet reported. Methods: Apoptosis was detected by flow cytometric analysis. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used for mRNA and protein quantification, respectively. A luciferase reporter assay was performed to verify downstream target genes for SNHG6 and miR-101-3p. Results: Dysregulation of SNHG6 inhibited apoptosis in ESCC cells and regulated the expression of apoptosis-related proteins such as Bcl-2, Mcl-1, Bax and Caspase-3. Functionally, miR-101-3p could compete binding with 3′-untranslated region of SNHG6 and downregulation of miR-101-3p reversed its effect on cell apoptosis in SNHG6 knockdown cells. EZH2 was confirmed as a downstream target gene of miR-101-3p, silencing EZH2 expression had the same effect on apoptosis and protein expression as knocking down SNHG6. Overexpression of EZH2 reversed the effects of miR-101-3p overexpression on cell apoptosis in ESCC cells. Conclusion: In this study, we found that upregulation of the lncRNA SNHG6 inhibited apoptosis via miR-101-3p/EZH2 axis in ESCC. These findings may contribute to the diagnosis and treatment of ESCC.

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The Association of Long Non-Coding RNA SNHG6 Expression with Clinicopathological Features and Prognosis in Cancer

Cited by 4 publications

References 0 publications

An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes

An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes

Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors

<p>LncRNA SNHG6 Inhibits Apoptosis by Regulating EZH2 Expression via the Sponging of MiR-101-3p in Esophageal Squamous-Cell Carcinoma</p>

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