The association of lipid metabolism with bone metabolism and the role of human traits: a Mendelian randomization study
Jian Kang,
Shuangli Zhao,
Xize Wu
et al.
Abstract:BackgroundThe impact of lipid metabolism on bone metabolism remains controversial, and the extent to which human traits mediate the effects of lipid metabolism on bone metabolism remains unclear.ObjectiveThis study utilized mendelian randomization to investigate the effects of blood lipids on bone mineral density (BMD) at various skeletal sites and examined the mediating role of human traits in this process.MethodsWe leveraged genetic data from large-scale genome-wide association studies on blood lipids (n=1,3… Show more
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