The association of individual allergen reactivity with respiratory disease in a national sample: Data from the second National Health and Nutrition Examination Survey, 1976–1980 (NHANES II)

Gergen, Peter J.; Turkeltaub, Paul C.

doi:10.1016/0091-6749(92)90130-t

Cited by 225 publications

(149 citation statements)

References 30 publications

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“…[3][4][5]8,15 Sensitization to Alternaria has been found to be significantly higher among subjects with asthma than among subjects without asthma. 35 We were unable to ascertain Alternaria sensitivity among the study participants because we lacked detailed information on their sensitization status. Although the odds of having asthma diagnosis were significantly higher among those who reported doctor-diagnosed allergies, the observed association between current asthma and indoor exposure to A alternata was not modified by atopy.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Alternaria alternata in US homes is associated with asthma symptoms

Salo

Arbes

Sever

et al. 2006

Journal of Allergy and Clinical Immunology

203

135

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Section: Discussionmentioning

confidence: 99%

Exposure to Alternaria alternata in US homes is associated with asthma symptoms

Salo

Arbes

Sever

et al. 2006

Journal of Allergy and Clinical Immunology

203

135

View full text Add to dashboard Cite

show abstract

“…Classically, outdoor allergens appear to constitute a greater risk for seasonal rhinitis than indoor allergens (284), and indoor allergens a greater risk for asthma and perennial rhinitis (285). However, studies using the ARIA classification show that over 50% of patients sensitized to pollen suffer from PER (62,67) and that, in the general population, a large number of patients sensitized to HDMs have mild IAR (62).…”

Section: Allergen Exposurementioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,754

1,761

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“…krakow inner city area study allergens. Allergic sensitisation to dog or cat allergens is believed to be an important risk factor for asthma and asthma symptoms, [1][2][3][4][5][6][7][8][9][10][11][12] and many studies reported positive correlations between the ownerships of pets and the excess in the occurrence of asthma symptoms, asthma diagnosis or asthma medication treatment. It was also shown that asthmatics are more likely than nonasthmatics sensitised to pet allergens and exposures to Can f 1 and Fel d 1 as low as 2 mg/g of house dust and 1 mg/g of dust, respectively, have been assumed as clinically relevant risk thresholds [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Validity of the interview on pets kept at home for predicting the actual domestic expsoure to their specific allergens. Krakow inner city area study

et al. 2008

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AbstractThe aim of the study was to describe the exposure to dog (Can f 1) and cat (Fel d 1) allergens within homes of very young children living with and without pets, and to assess the validity of the interview on pets for predicting the actual exposure to pet allergens in house dust. House dust samples were collected in 275 dwellings from the mattresses, children’s bedroom and kitchen floors. In the laboratory, dust samples were analyzed for Can f 1 and Fel d 1 using monoclonal antibody enzyme-linked immunosorbent assays (ELISA). The majority of households (79.3%) had neither a dog nor a cat living in the home over the past 6 months preceding the survey. Dog allergen above 2 μg/g dust were found in 22.5% of homes and 14.2% of homes contained dog allergen above 10 μg/g of house dust. In the total study sample, cat allergen above 1 μg/g of dust were found in 12.7% of homes, and 3.3% of homes contained Fel d 1 levels greater than 8 μg/g of dust. The majority of children (75.0%) with reported ownership of dogs were exposed to Can f 1 levels above 2 μg/g of house dust, and 73.1% of children with cats at home were exposed to Fel d 1 concentrations above 1 μg/g house dust. The results of the study showed that post-test probability of the true exposure to Can f 1 above 2 μg/g dust in houses with positive interview on indoor dogs was 75.0% (95%CI: 61.7–84.8%). On the other hand, the prediction of exposure estimated from the interview data on indoor dogs produced 12.6% of false negatives (95% CI: 9.9–15.8%). Similarly, the post-test probability of the true exposure to Fel d 1 above 1 μg/g dust in houses with positive interview on indoor cats was 73.1% (95%CI: 55.1–85.7%). On the other hand, the interview data produced 6.4% false negatives (95% CI: 4.6–9.0%). In conclusion, the study demonstrated that homes in Poland with pet ownership are important reservoir of Can f 1 and Fel d 1 allergens with levels that might induce allergic symptoms. Even in homes of children without a dog or cat indoors, there was a higher prevalence of pet allergens at the levels above allergic sensitisation thresholds. This may have an important implication for epidemiologic studies on pet related allergy and prevention practice.

show abstract

The association of individual allergen reactivity with respiratory disease in a national sample: Data from the second National Health and Nutrition Examination Survey, 1976–1980 (NHANES II)

Cited by 225 publications

References 30 publications

Exposure to Alternaria alternata in US homes is associated with asthma symptoms

Exposure to Alternaria alternata in US homes is associated with asthma symptoms

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Validity of the interview on pets kept at home for predicting the actual domestic expsoure to their specific allergens. Krakow inner city area study

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