The association of impaired semen quality and pregnancy rates in assisted reproduction technology cycles: Systematic review and meta‐analysis

Giudice, Francesco Del; Belladelli, Federico; Chen, Tony; Glover, Frank; Mulloy, Evan; Kasman, Alex M.; Sciarra, Alessandro; Salciccia, Stefano; Canale, Vittorio; Maggi, Martina; Ferro, Matteo; Busetto, Gian Maria; Berardinis, Ettore De; Salonia, Andrea

doi:10.1111/and.14409

Cited by 18 publications

(10 citation statements)

References 56 publications

(92 reference statements)

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“…Accordingly, ICSI rather than IVF has been commonly suggested in cases of reduced normal morphology or severe teratozoospermia (< 5%) 46 . Notwithstanding, several studies have reported that the clinical pregnancy rates in couples in which the male partner had severe teratozoospermia did not change according to the method of insemination 35,37,47–49 . Keegan et al 38 .…”

Section: Search Methodsmentioning

confidence: 99%

“…46 Notwithstanding, several studies have reported that the clinical pregnancy rates in couples in which the male partner had severe teratozoospermia did not change according to the method of insemination. 35,37,[47][48][49] Keegan et al 38 in a retrospective study of 495 couples undergoing ART treatments with IVF and ICSI, in whom the male partners were diagnosed with teratozoospermia, found no statistical difference in fertilization, FF, pregnancy, and LBR. Finally, Hotaling et al confirmed this finding in a large study including about 3000 IVF/ICSI treatments, concluding that the use of ICSI rather than IVF yields no difference in pregnancy outcomes in patients with severe teratozoospermia.…”

Section: Icsi In Cases Of Borderline Semen Assessment (Oligo-astheno-...mentioning

confidence: 99%

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Intracytoplasmic sperm injection vs. in‐vitro fertilization in couples in whom the male partners had a semen analysis within normal reference ranges: An open debate

Sciorio

Fleming

2023

Andrology

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During recent decades, the application of intracytoplasmic sperm injection has increased considerably worldwide, especially in couples with non‐male factor infertility. However, several studies analyzing the broad use of intracytoplasmic sperm injection, even in cases with a normal semen analysis, have collectively demonstrated no benefits compared to conventional in‐vitro fertilization. Currently, there is insufficient evidence to support the intracytoplasmic sperm injection technique vs. in‐vitro fertilization in cases of poor ovarian response or a low number of oocytes collected, or in patients with advanced maternal age. Since the intracytoplasmic sperm injection technique is more operator‐dependent and invasive, its use should only be recommended in cases of male‐factor infertility. There is some evidence showing that intracytoplasmic sperm injection is linked with an increased risk of birth defects. Albeit this evidence is limited, and currently it is not possible to draw a firm conclusion on these concerns, we do believe that these risks should be rigorously investigated. Thus, this review aims to clarify the debate on the application of the intracytoplasmic sperm injection procedure, as compared to standard in‐vitro fertilization, in those assisted reproductive technology cycles without a clear male factor infertility. Furthermore, we try to clarify whether intracytoplasmic sperm injection would result in a higher live birth rate than in‐vitro fertilization, in couples with non‐male factor infertility.

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Section: Search Methodsmentioning

confidence: 99%

Section: Icsi In Cases Of Borderline Semen Assessment (Oligo-astheno-...mentioning

confidence: 99%

Intracytoplasmic sperm injection vs. in‐vitro fertilization in couples in whom the male partners had a semen analysis within normal reference ranges: An open debate

Sciorio

Fleming

2023

Andrology

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“…IVF and later IVF-ICSI were developed in order to achieve pregnancy even in the most severe forms of male infertility. A recent meta-analysis has shown that semen quality, as assessed by a standard semen analysis, does not impact IVF and ICSI pregnancy rates [17]; in the past several years, we see a rise in the use of IVF/ICSI to overcome male factor [18].…”

Section: Varicocele Repair and In-vitro Fertilizationmentioning

confidence: 99%

The contemporary role of varicocele repair: why operate when in-vitro fertilization results are so good?

Gal

Goldstein

2022

Current Opinion in Urology

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Purpose of review A male factor is either the primary cause or is contributory in at least half of all couples with infertility. Currently, many male factor problems may be disregarded, as reproductive technology has advanced so much that in-vitro fertilization (IVF)/Intracytoplasmic sperm injection (ICSI) allows the use of even a single sperm to achieve pregnancy. Recent findings Varicocele is the most commonly diagnosed correctable cause. Microsurgical repair is considered the gold standard for repair. Research has shown that varicocele repair can impact the outcome of reproductive management and upgrade male infertility from adoption or donor sperm only to IVF/ICSI and microTESE, or IVF/ICSI with ejaculated sperm, or from IVF/ICSI to intrauterine insemination (IUI) or often naturally conceived. Summary Varicocele diagnosis and repair is an essential part of infertility evaluation. Not only does it potentially impact antiretroviral therapy choices, but it can also increase testosterone levels benefiting long-term male health.

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“…The decline in fertility in both males and females and the trend of delaying pregnancy to a later age have promoted the development of ARTs [ 17 ]. However, the moderate success rate of pregnancy and the unclear mechanisms behind it are hindering the wide use of ARTs [ 122 ]. In addition, some studies observe a higher risk of adverse outcomes in ART-conceived babies (and animals) than in naturally conceived ones [ 123–126 ], pushing us to update our understanding in this area.…”

Section: Reproductive Tract Microbiome and Artsmentioning

confidence: 99%

Microbiome in Female Reproductive Health: Implications for Fertility and Assisted Reproductive Technologies

Xiao,

Zuo,

Zhao

2023

Genomics, Proteomics &Amp; Bioinformatics

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The microbiome plays a critical role in the process of conception and the outcomes of pregnancy. Disruptions in microbiome homeostasis in women of reproductive age can lead to various pregnancy complications, which significantly impact maternal and fetal health. Recent studies have associated the microbiome in the female reproductive tract (FRT) with assisted reproductive technology (ART) outcomes, and restoring microbiome balance has been shown to improve fertility in infertile couples. This review provides an overview of the role of the microbiome in female reproductive health, including its implications for pregnancy outcomes and ARTs. Additionally, recent advances in the use of microbial biomarkers as indicators of pregnancy disorders are summarized. A comprehensive understanding of the characteristics of the microbiome before and during pregnancy and its impact on reproductive health will greatly promote maternal and fetal health. Such knowledge can also contribute to the development of ARTs and microbiome-based interventions.

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The association of impaired semen quality and pregnancy rates in assisted reproduction technology cycles: Systematic review and meta‐analysis

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 18 publications

References 56 publications

Intracytoplasmic sperm injection vs. in‐vitro fertilization in couples in whom the male partners had a semen analysis within normal reference ranges: An open debate

Intracytoplasmic sperm injection vs. in‐vitro fertilization in couples in whom the male partners had a semen analysis within normal reference ranges: An open debate

The contemporary role of varicocele repair: why operate when in-vitro fertilization results are so good?

Microbiome in Female Reproductive Health: Implications for Fertility and Assisted Reproductive Technologies

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