The Association of<i>Streptococcus gallolyticus</i>Subspecies<i>pasteurianus</i>Bacteremia with the Detection of Premalignant and Malignant Colonic Lesions

Chand, Gaurav; Shamban, Leonid; Forman, Adam; Sinha, Prabhat

doi:10.1155/2016/7815843

Cited by 14 publications

(7 citation statements)

References 9 publications

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“…A relationship between Sgg -induced endocarditis and CRC was established for the first time by McCoy and Mason (1951) . Later on, several epidemiological studies confirmed this association ranging from 47 to 85% between Sgg and CRC, depending on the techniques used for Sgg detection ( Klein et al, 1977 ; Waisberg et al, 2002 ; Kok et al, 2007 ; Gupta et al, 2010 ; Corredoira et al, 2015 ; Chand et al, 2016 ). Most of these studies were performed on a selected cohort of patients with a history of Sgg bacteremia/endocarditis.…”

Section: Introductionmentioning

confidence: 93%

Significance of Streptococcus gallolyticus subsp. gallolyticus Association With Colorectal Cancer

et al. 2018

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Streptococcus gallolyticus subsp. gallolyticus Sgg (formerly known as S. bovis type I) is the main causative agent of septicemia and infective endocarditis (IE) in elderly and immunocompromised persons. It belongs to the few opportunistic bacteria, which have been strongly associated to colorectal cancer (CRC). A literature survey covering a period of 40 years (1970–2010) revealed that 65% of patients diagnosed with an invasive Sgg infection had a concomitant colorectal neoplasia. Sgg is associated mainly with early adenomas and may thus constitute an early marker for CRC screening. Sgg has been described as a normal inhabitant of the rumen of herbivores and in the digestive tract of birds. It is more rarely detected in human intestinal tract (2.5–15%). Recent molecular analyses indicate possible zoonotic transmission of Sgg. Thanks to the development of a genetic toolbox and to comparative genomics, a number of factors that are important for Sgg pathogenicity have been identified. This review will highlight the role of Sgg pili in host colonization and how their phase-variable expression contributes to mitigate the host immune responses and finally their use as serological diagnostic tool. We will then present experimental data addressing the core question whether Sgg is a cause or consequence of CRC. We will discuss a few recent studies examining the etiological versus non-etiological participation of Sgg in colorectal cancer with the underlying mechanisms.

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Section: Introductionmentioning

confidence: 93%

Significance of Streptococcus gallolyticus subsp. gallolyticus Association With Colorectal Cancer

et al. 2018

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“…pasteurianus (SGSP), formerly known as S. bovis biotype II/2 [1] and is one member of Group D streptococci, is a cause and a potential pathogen of bacteremia and infective endocarditis (IE), as well as urinary tract infection (UTI), in elderly and immunodeficient people [2–4], septicemia and meningitis in newborns, and as well as intrauterine infection in pregnant woman [5–8]. This species is also associated with gastrointestinal malignancy [3, 9]. It colonizes the digestive and female genital tract and therefore can lead to UTI and neonatal invasive infection, resembling what happens with group B Streptococcus ( S. agalactiae , GBS).…”

Section: Introductionmentioning

confidence: 99%

Microbiological and clinical characteristics of Streptococcus gallolyticus subsp. pasteurianus infection in China

Chen

Zhang

et al. 2019

BMC Infect Dis

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Background Infections by Streptococcus gallolyticus subsp. pasteurianus (SGSP) is often underestimated. Herein, the epidemiological features and resistant characteristics of SGSP in mainland China are characterized to enable a better understanding of its role in clinical infections. Methods In the present work, 45 SGSP isolates were collected from the samples of bloodstream, urine, aseptic body fluid, and fetal membrane/placenta from patients in 8 tertiary general hospitals of 6 cities/provinces in China from 2011 to 2017. The identification of all isolates was performed using traditional biochemical methods, 16S rRNA and gyrB sequencing, followed by the characterization of their antibiotic resistance profiling and involved genes. Results Among 34 non-pregnancy-related patients, 4 (4/34,11.8%) patients had gastrointestinal cancer, 10 (10/34, 29.4%) patients had diabetes, and one patient had infective endocarditis. Moreover, 11 cases of pregnant women were associated with intrauterine infection (9/11, 81.2%) and urinary tract infection (1/11, 9.1%), respectively. Except one, all other SGSP isolates were correctly identified by the BD Phoenix automated system. We found that all SGSP isolates were phenotypically susceptible to penicillin, ampicillin, cefotaxime, meropenem, and vancomycin. Forty strains (40/45, 88.9%) were both erythromycin and clindamycin-resistant, belonging to the cMLSB phenotype, and the majority of them carried erm(B) gene (39/40, 97.5%). Although the cMLSB/erm(B) constituted the most frequently identified phenotype/genotype combination (25/40, 62.5%) among all erythromycin-resistant cMLSB isolates, erm(B)/erm(A), erm(B)/mef(A/E), and erm(B)/erm(T) was detected in 7, 4, and 3 isolates, respectively. Furthermore, 43 strains (43/45, 95.6%) were tetracycline-resistant, and out of these, 39 strains (39/45, 86.7%) carried tet(L), 27(27/45, 60.0%) strains carried tet(O), and 7 (7/45, 15.6%) strains carried tet(M), alone or combined, respectively. All erythromycin-resistant isolates were also resistant to tetracycline. Conclusions It is important to study and draw attention on SGSP, an underreported opportunistic pathogen targeting immunodeficient populations, notably elderly subjects, pregnant women and neonates.

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“…Moreover, retrospective studies and several case reports have shown possible associations between bacteremia from certain intestinal microbes, including B. fragilis and premalignant and malignant colon lesions. Intestinal dysbiosis and perturbed barrier function are the most probable mechanisms described for these bacteria to enter the bloodstream [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Bacteroides fragilis Bacteremia Complicated by Spondylodiscitis, Spinal Epidural Abscess, and Sepsis: A Case Report

et al. 2022

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Patient: Male, 63-year-old Final Diagnosis: Spondylodiscitis, spinal epidural abscess and sepsis as a complication of Bacteroides fragilis bacteraemia Symptoms: Fever and altered level of consciousness. Significant thoracic spine pain was also reported during the last three months Medication: — Clinical Procedure: Surgical decompressive therapy, with abscess drainage, combined with appropriate antibiotic therapy for twelve weeks Specialty: Medicine, General and Internal Objective: Rare coexistence of disease or pathology Background: Pyogenic spondylitis comprises several clinical entities, including native vertebral osteomyelitis, septic discitis, pyogenic spondylodiscitis, and epidural abscess. The lumbar spine is most often infected, followed by the thoracic and cervical areas. It mainly develops (i) after spine surgery; (ii) from history of blunt trauma to the spinal column; (iii) from infections in adjacent structures (such as soft tissues); (iv) from iatrogenic inoculation after invasive procedures (such as lumbar puncture); and (v) from hematogenous bacterial spread to the vertebra (mainly through the venous route). Any delay in diagnosis and treatment can lead to significant spinal cord injury, permanent neurological damage, septicemia, and death. Case Report: We describe a 63-year-old man with no significant past medical history who presented with fever and an altered level of consciousness. Significant thoracic spine pain was also reported during the last 3 months. The final diagnosis was vertebral spondylodiscitis, contiguous spinal epidural abscess, and sepsis due to Bacteroides fragilis bacteremia. Clinical recovery was achieved after surgical decompressive therapy with abscess drainage combined with appropriate antibiotic therapy for 12 weeks. The primary focus of the infection was not clarified, despite all the investigations that were performed. Conclusions: Spondylodiscitis, spinal epidural abscess, and sepsis as complications of Bacteroides fragilis bacteremia are rare in a patient without any previously known predisposing conditions and without an obvious primary focus. Early diagnosis and proper treatment of anaerobic spondylodiscitis, especially if epidural abscess and sepsis are present, are of great importance to reduce mortality and avoid long-term complications.

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The Association ofStreptococcus gallolyticusSubspeciespasteurianusBacteremia with the Detection of Premalignant and Malignant Colonic Lesions

Cited by 14 publications

References 9 publications

Significance of Streptococcus gallolyticus subsp. gallolyticus Association With Colorectal Cancer

Significance of Streptococcus gallolyticus subsp. gallolyticus Association With Colorectal Cancer

Microbiological and clinical characteristics of Streptococcus gallolyticus subsp. pasteurianus infection in China

Bacteroides fragilis Bacteremia Complicated by Spondylodiscitis, Spinal Epidural Abscess, and Sepsis: A Case Report

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