The association of LAMB1 polymorphism and expression changes with the risk of coal workers' pneumoconiosis

Abstract

In this study, the functional LAMB1 rs4320486 mutation was associated with a decreased risk of CWP in a Chinese population, probably owing to the reduced activity of LAMB1 transcription. LAMB1 expression was increased in the progress of lung fibrosis, which suggests that LAMB1 may affect the initiation and progression of pneumoconiosis, or serve as a potential biomarker of pneumoconiosis for diagnosis and genetic susceptibility.

Identification of the difference of neutrophils in different locations in RA patients

“…Laminin beta 1(LAMB1) is highly expressed in lung tissue and it is critical for both lung morphogenesis and physiological function 26 . KRAS is the most mutated oncogene in cancer and its receptor AMG 510 contributes the regression of KRAS mutant tumors and improves the anti-tumor e cacy of chemotherapy via formation a pro-in ammatory tumor microenvironment 27 .…”

Meslek Hastaliklariyla İli̇şki̇li̇ Geneti̇k Poli̇morfi̇zmleri̇n Moleküler Mekani̇zmalari

“…Lamininler, α, β ve γ zincirlerinden oluşan bir multidomain olup heterotrimerik protein ailesine aittir. ECM'nin yapısına katkıda bulunurlar ve yapışma, göç, farklılaşma, fenotip stabilitesi ve apoptoza direnç gibi ilişkili hücrelerin biyolojik davranışlarını etkilerler(22). CDE veya sigara içme durumuyla etkileşime girdiğinde silikoz açısından bireysel duyarlılık ile ilişkilendirilebilir…”