The Association of Human Papillomavirus in Benign and Malignant Laryngeal Lesions—a Pilot Study

George, Philip; Mani, Suresh; Abraham, Priya; Michael, Rajiv C

doi:10.1007/s13193-020-01127-1

Cited by 1 publication

(2 citation statements)

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“… 20 Among the two studies on LC, only a single study reporting a prevalence of 13.3% was taken for analysis as it fulfills the eligibility criteria. 21 The differences in the proportion between the sites indicate that HPV has a varying degree of pathogenicity in these anatomic sites. However, other risk factors such as tobacco and alcohol increase the overall risk of oncogenesis in these regions.…”

Section: Discussionmentioning

confidence: 99%

“…Bandhary et al 24 Bhattacharya et al 22 Bhosale et al 32 George et al 21 Gheit et al 53 Gholap et al 54 Koppikar et al 26 Mitra et al 59 Murthy et al 9 Sannigrahi et al 65 Sarmah et al 66 Sarkar et al 69 Overall (l 2 = 73.35%, P = .00) high incidence of OC in the age group of 40-69 years in West Bengal. 22 The north and northeast (NE) regions were underrepresented as there were only three studies with smaller sample sizes from this region.…”

Section: Studymentioning

confidence: 98%

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Human Papillomavirus–Attributable Head and Neck Cancers in India—A Systematic Review and Meta-Analysis

Vani,

Rama,

Madhanagopal

et al. 2024

JCO Glob Oncol

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PURPOSE Head and neck cancer accounts for about one third of the global burden in India. Mucosal high-risk human papillomavirus (HPV) has been hypothesized as a contributory risk factor for head and neck cancer (HNC) but its prevalence in Indian patients is not well established. Therefore, this systematic review and meta-analysis aimed to estimate the prevalence of HPV in HNC in India and their attributable fraction by considering the biomarkers of carcinogenesis, p16, and HPV E6/E7 mRNA. METHODS A systematic literature search was done in Medline via PubMed, Embase, Scopus, ScienceDirect, ProQuest, and Cochrane to identify studies on HPV and HNC in the Indian population, published between January 1990 and October 2022. Fifty-four eligible studies were identified and relevant clinical information was collected. Meta-analysis was conducted to estimate the pooled prevalence of HPV DNA, p16INK4a, and E6/E7 mRNA percent positivity by random-effect logistic regression model using Metapreg, STATA 18. RESULTS Thirty-four high-quality studies were taken for meta-analysis. The pooled prevalence of HPV in HNC was 20% (95% CI, 12 to 32) with a high level of heterogeneity ( I2 = 90.79%). The proportion of HPV in oropharyngeal cancer (OPC; 22% [95% CI, 13 to 34]) and laryngeal cancer (LC; 29% [95% CI, 17 to 46]) was higher than in oral cancer (OC; 16% [95% CI, 8 to 30]). The HPV-attributable fraction of OPC, considering the E6/E7 mRNA and p16 positivity, was 12.54% and 9.68%, respectively, almost similar to LC (11.6% and 9.57%), while it was much lower in OC (3.36% and 4%). CONCLUSION The HPV-attributable fraction is considerably lower for OC, suggesting a negligible causative role of HPV in OC. A significant proportion of OPC and LC are attributed to HPV; however, their exact causative role is unclear because of the presence of other known risk factors.

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Section: Discussionmentioning

confidence: 99%