The association of Haptoglobin polymorphism with Crohn's disease in Israel

Abstract

We found a borderline significant decrease of the Haptoglobin 1-1 phenotype in Israeli Crohn's disease patients compared to healthy controls. Our findings may support the importance of inflammation in Crohn's disease pathogenesis and the protective function of Haptoglobin 1-1 in the susceptibility for Crohn's disease.

Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis

“…Our results agree with data published by Maza et al , who found that genotype 11 was significantly less common in CD,15 as was also shown in other immune-based diseases 2 3 35. However, the results contradict those reported for a Hungarian cohort, where a higher frequency of genotype 11 was found in CD 16.…”

Biological markers of disease activity in inflammatory bowel diseases

“…demonstrated that HP11 was significantly less common in CD, while Papp et al . showed its higher frequency in CD [ 44 , 45 ]. However, in a well-powered study from the Marques group HP2 was found to be a risk allele for IBD, with a higher frequency in both CD and UC compared with controls [ 46 ].…”

Smoking and the correlation between birth weight and placental weight. Evidence of interaction with maternal haptoglobin phenotype

“…There is evidence of functional differences between polymers of Hp2-1 and polymers of Hp2 phenotypes [8]. This protein protects against hemoglobin peroxidation and its phenotypes have been linked to several diseases such as coronary artery disease, type 1 diabetes, Crohn's disease, inflammatory diseases, Parkinson, malaria, moreover it may be an indicator of neonatal jaundice, a predictor of nephropathy in type 2 diabetes and shows a protective role in the brain after intra-cerebral hemorrhage [9][10][11][12][13][14][15][16][17].…”