The association of glycated hemoglobin A1c with coronary artery disease, myocardial infarction, and severity of coronary lesions

Wei, Yuanyuan; Li, Wenyuan; Luan, Hui; Tuerhongjiang, Gulinigaer; Yuan, Zuyi; Wu, Yue

doi:10.1177/10815589221140593

Cited by 3 publications

(1 citation statement)

References 46 publications

(47 reference statements)

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“…37 HbA1c has been recognized as a predictor of cardiovascular events. 38 There is a sustained relationship between HbA1c and CHD risk, even below the diagnostic threshold for diabetes. 39 Novel stratification of lipid risk, simply using triglyceride and non-high-density lipoprotein cholesterol levels, combined with FMD measurement, is useful for predicting cardiovascular outcomes in patients with coronary artery disease.…”

Section: Biomarker Detection Of Vascular Aging and Endothelial Dysfun...mentioning

confidence: 99%

Vascular Health Promotion Project and Vascular Medicine in China-CCVM2004-2023

Wen,

Jiang,

Yuan

et al. 2023

VHRM

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Cardiovascular disease(CVD) has become a major disease burden affecting people's health in China. Blood vessels are very important for human health and are the "sentinel" for the development of many cardiovascular and cerebrovascular diseases. The key to effectively preventing fatal, disabling heart, brain and peripheral vascular events lies in controlling traditional and nontraditional risk factors for vascular health from the source, and early assessment and intervention of early vascular lesions. Since 2004, China government promoted the early detection technology of vascular lesions and vascular medicine, and proposed the Beijing Vascular Health Stratification (BVHS) to provide suggestions for the examination, evaluation and management of risk factors, and to provide new ideas for lifelong maintenance of vascular health. This review mainly introduces the establishment and development of the clinical discipline of "vascular medicine" in the past 20 years in China, introduces the indicators for detecting vascular function and structure and the predictive value of vascular events, and carries out intelligent and digital management of vascular health throughout the life cycle of individualized prevention, treatment and rehabilitation for people with different parts or degrees of lesions, effectively reducing the occurrence and development of cardiovascular and cerebrovascular diseases, and the prospect of new technology in maintaining vascular health.

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Section: Biomarker Detection Of Vascular Aging and Endothelial Dysfun...mentioning

confidence: 99%

Vascular Health Promotion Project and Vascular Medicine in China-CCVM2004-2023

Wen,

Jiang,

Yuan

et al. 2023

VHRM

View full text Add to dashboard Cite

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The relationship between glycated hemoglobin (HbA1c), hematocrit, mean platelet volume, total white blood cell counts, Visceral Adiposity Index, and Systematic Coronary Risk Evaluation 2 (SCORE2) in patients without diabetes

Yesiloglu,

Emiroglu,

Aypak

2024

Int J Diabetes Dev Ctries

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Comprehensive analysis of the association between triglyceride-glucose index and coronary artery disease severity across different glucose metabolism states: a large-scale cross-sectional study from an Asian cohort

Zhao,

Wang,

Qing

et al. 2024

Cardiovasc Diabetol

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Background The triglyceride-glucose (TyG) index is associated with the development and prognosis of coronary artery disease (CAD). However, the impact of the TyG index on CAD severity across different glucose metabolism states exhibits significant disparities in previous research. Methods This cross-sectional study comprised 10,433 participants from a prospective cohort. Participants were categorized into four groups based on glucose metabolism state: normal glucose regulation (NGR), prediabetes (pre-DM), diabetes mellitus (DM) without insulin prescribed (Rx), and DM with insulin Rx. The TyG index was determined by the following formula: Ln [TG (mg/dL) × FPG (mg/dL) / 2], where TG is triglycerides and FPG is fasting plasm glucose. Statistical methods such as binary logistic regression, interaction analysis, restricted cubic spline (RCS), and receiver operating characteristic (ROC) were employed to analyze the relationship between the TyG index and CAD severity across the entire population and glucose metabolism subgroups. Mediation analysis was conducted to examine the mediating effects of glycated hemoglobin (HbA1c) on these relationships. Sensitivity analysis was performed to ensure the robustness of the findings. Results Multivariable logistic regression analysis revealed a significant positive association between the TyG index and multi-vessel CAD in the entire population (OR: 1.34; 95% CI: 1.22–1.47 per 1-unit increment). Subgroup analysis demonstrated consistent positive associations in the NGR, pre-DM, and DM non-insulin Rx groups, with the highest OR observed in the NGR group (OR: 1.67; 95% CI: 1.3–2.14 per 1-unit increment). No correlation was found in the DM with insulin Rx subgroup. RCS analyses indicated the distinct dose-response relationships across different glucose metabolism subgroups. Including the TyG index in the established model slightly improved the predictive accuracy, particularly in the NGR group. Mediation analyses showed varying mediating effects of HbA1c among different glucose metabolism subgroups. Sensitivity analysis confirmed the robustness of the aforementioned relationships in the new-onset CAD population and in individuals not using antilipidemic medications. Conclusions The TyG index positively associated with CAD severity across all glucose metabolism states, except for individuals receiving insulin treatment. Moreover, it might serve as a supplementary noninvasive predictor of CAD severity in addition to established factors, especially in NGR patients. Graphical abstract

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The association of glycated hemoglobin A1c with coronary artery disease, myocardial infarction, and severity of coronary lesions

Cited by 3 publications

References 46 publications

Vascular Health Promotion Project and Vascular Medicine in China-CCVM2004-2023

Vascular Health Promotion Project and Vascular Medicine in China-CCVM2004-2023

The relationship between glycated hemoglobin (HbA1c), hematocrit, mean platelet volume, total white blood cell counts, Visceral Adiposity Index, and Systematic Coronary Risk Evaluation 2 (SCORE2) in patients without diabetes

Comprehensive analysis of the association between triglyceride-glucose index and coronary artery disease severity across different glucose metabolism states: a large-scale cross-sectional study from an Asian cohort

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