The Association of Glucose Variability and Dementia Incidence in Latinx Adults with Type 2 Diabetes: A Retrospective Study

Abstract

Latinx adults with both cognitive dysfunction and type 2 diabetes mellitus (T2DM) are significantly more likely than Latinx adults with diabetes alone to have complications such as cardiovascular disease. Glucose variability may be a risk for dementia, but the course of glucose variability in the time before a dementia diagnosis for Latinx adults with T2DM has not been examined. We used a 10-year retrospective cohort of medical records of Latinx patients with T2DM who had at least one use of a continuous glucose monitor. The objective was to examine how glucose variability was associated with future dementia diagnoses. A total of 116 charts were included. Mean of daily differences and mean amplitude of glycemic excursions were more strongly associated with dementia diagnoses than other variability indices ( p < .01). Understanding the relationships between cognitive function, glucose variability, and barriers to health care can translate into improved interventions to enhance diabetes care.

Glucose Metabolism and Cognitive Decline in Progressive Supranuclear Palsy and Corticobasal Syndrome: A Preliminary Study

“…However, that study [7] did not provide details concerning final diagnoses of analyzed patients, with the exception of dividing the analyzed group into mild cognitive impairment, subjective cognitive impairment, probable AD, probable vascular dementia and untyped dementia. The correlation between glucose variability and future dementia diagnosis was found in a 10-year retrospective study conducted on Latinx adults with diabetes mellitus type 2 (T2DM) [28]. Blood glucose variability was associated with cognitive dysfunction and the level of lacunar infarctions' burden among patients with T2DM [29].…”