The association of genetic polymorphisms with cerebral palsy: a meta-analysis

Wu, De; Zou, Yanfeng; Xu, Xiaoyan; Feng, Xiao-Liang; Li, Yang; Zhang, Gong-Chun; Bu, Xi-Song; Tang, Jue

doi:10.1111/j.1469-8749.2010.03884.x

Cited by 45 publications

(41 citation statements)

References 36 publications

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“…IL-6 is produced by a variety of cells and plays important roles in regulating hematopoiesis, immune cell activation, inflammation, and carcinogenesis [8]. A common G>C polymorphism of the IL-6 promoter at position –174 has been investigated in a wide variety of diseases, such as breast cancer [9], cerebral palsy [10], and hip and knee osteoarthritis [11]. Several studies were conducted to investigate the association of the polymorphism with PCa risk [12,13,14,15,16,17].…”

Section: Introductionmentioning

confidence: 99%

The Interleukin-6 –174G/C Polymorphism and Prostate Cancer Risk: A Systematic Review and Meta-Analysis

Zhang

et al. 2012

Urol Int

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Objective: This systematic review and meta-analysis was undertaken to integrate previous findings and summarize the effect size of the association of interleukin-6 (IL-6) genetic polymorphism –174G/C with susceptibility to prostate cancer (PCa). Methods: All eligible studies of IL-6 –174G/C polymorphism and PCa risk were collected from the following electronic databases: PubMed and the Cochrane Library, with the last report up to June 1, 2011. Statistical analyses were performed by Review Manage version 5.0 and Stata 10.0. Results: A total of 7 independent studies, including 9,959 cases and 12,361 controls, were identified. When all studies were pooled, we did not detect a significant association of –174G/C polymorphism with PCa risk. When stratifying for race, similar results were obtained; evidence of a significant relation was absent in both Caucasians and the mixed population. After stratifying the studies by study types, –174G/C polymorphism was significantly associated with PCa risk when examining the contrast of CC + GC versus GG (OR = 1.44, 95% CI = 1.05–1.98, p = 0.03) in cohort studies but not in case-control studies. Conclusions: Our review suggest that –174G/C polymorphism is associated with an increased PCa risk in two cohort studies from one article. Additional well-designed studies are warranted to validate these findings.

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Section: Introductionmentioning

confidence: 99%

The Interleukin-6 –174G/C Polymorphism and Prostate Cancer Risk: A Systematic Review and Meta-Analysis

Zhang

et al. 2012

Urol Int

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“…En población caucásica también se han encontrado la asociación del polifmorfismo (rs1800795) de IL6 con PC. 39,44 Pese a la asociación existente descrita entre polimorfismos en el gen de IL-6 y PC, es poco lo que se conoce del comportamiento genético en esta patología, los estudios existentes han encontrado relación de factores genéticos, dado por polimorfismos en factores pro inflamatorios (IL.6) en niños con factores de riesgo neurológico con parálisis cerebral. 44 Muchos estudios en los últimos 20 años y soportados por el grupo de la Dra.…”

Section: Introductionunclassified

“…39,44 Pese a la asociación existente descrita entre polimorfismos en el gen de IL-6 y PC, es poco lo que se conoce del comportamiento genético en esta patología, los estudios existentes han encontrado relación de factores genéticos, dado por polimorfismos en factores pro inflamatorios (IL.6) en niños con factores de riesgo neurológico con parálisis cerebral. 44 Muchos estudios en los últimos 20 años y soportados por el grupo de la Dra. Novak en Australia [22][23][24][25][26][27][28][29][30][31][32][33] confirman que el 20-25% de casos de parálisis cerebral moderada o severa se asocian con malformación congénitas del sistema nervioso central.…”

Section: Introductionunclassified

Asociaciones genéticas en la parálisis cerebral; un campo aún en estudio

Arroyo¹,

Franco²,

Valencia³

2016

Rev Col Med Fis Reh

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“…Genetic factors are likely to have a role in the pathogenesis of brain injury and CP [7] . Several genes involved in inflammation, infection, and coagulation [8][9][10] have been proposed as potential candidates for CP susceptibility. Recent studies assessing genes encoding tumor necrosis factor, interleukin-6, prothrombin, factor V Leiden, apolipoprotein E, methylenetetrahydrofolate reductase, lymphotoxin-α, and others have yielded modest or no associations with CP [9,11] .…”

Section: Introductionmentioning

confidence: 99%

Cerebral Palsy and Polymorphism of the Chemokine <b><i>CCL18</i></b> in Very Preterm Children

et al. 2015

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Background: Prematurity and hereditary factors predispose to cerebral palsy (CP).Previously, low cord blood levels of the anti-inflammatory chemokine CCL18 have been found to be associated with risk of CP in preterm children. Objectives: To investigate the association between single nucleotide polymorphisms (SNPs) in CCL18 and susceptibility to CP, as well as the association between the SNPs and cord blood levels of CCL18. Methods: The original population comprised very-low-gestational-age (VLGA; <32 weeks) children from northern and central Finland (25 cases, 195 controls). Five CCL18 SNPs were genotyped and examined for associations with CP and cord blood CCL18. The replication population comprised Caucasian VLGA children from southern Finland and Canada (23 cases, 248 controls). Results: In the original population, SNP rs2735835 was associated with CP; the minor allele A was underrepresented in cases compared to controls (OR = 0.42, 95% CI: 0.21-0.83, p = 0.01). This association remained significant after adjustment for multiple testing and risk factors of CP, and after combining the original and replication populations (OR = 0.52, 95% CI: 0.33-0.83, p = 0.005). Intraventricular hemorrhage (IVH) additively predicted CP. The Rs2015086 genotype was modestly associated with CCL18 concentration. Conclusions: A common CCL18 polymorphism together with IVH had an additive influence on CP susceptibility. Developmentally regulated CCL18, confined to primates, may be involved in the complex sequence of events leading to brain injury and predisposition to CP phenotype.

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The association of genetic polymorphisms with cerebral palsy: a meta-analysis

Cited by 45 publications

References 36 publications

The Interleukin-6 –174G/C Polymorphism and Prostate Cancer Risk: A Systematic Review and Meta-Analysis

The Interleukin-6 –174G/C Polymorphism and Prostate Cancer Risk: A Systematic Review and Meta-Analysis

Asociaciones genéticas en la parálisis cerebral; un campo aún en estudio

Cerebral Palsy and Polymorphism of the Chemokine <b><i>CCL18</i></b> in Very Preterm Children

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