The association of frailty with serum 25-hydroxyvitamin D and parathyroid hormone levels in older European men

Tajar, Abdelouahid; Lee, David M.; Pye, Stephen R.; O’Connell, Matthew; Ravindrarajah, Rathi; Gielen, Evelien; Boonen, Steven; Vanderschueren, Dirk; Pendleton, Neil; Finn, Joseph D.; Bártfai, G; Casanueva, Felipe F.; Forti, Gianni; Giwercman, Aleksander; Han, Thang S.; Huhtaniemi, Ilpo; Kula, Krzysztof; Lean, Michael E. J.; Punab, Margus; Wu, Frederick C. W.; O'Neill, Terence W

doi:10.1093/ageing/afs162

Cited by 76 publications

(46 citation statements)

References 30 publications

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“…These properties can be dependent or independent of its binding on the nuclear receptor vitamin D receptor (VDR). Many studies have suggested that vitamin D is related to muscle strength and frailty [55][56][57] .…”

Section: Vitamin Dmentioning

confidence: 99%

Oral Drugs Related with Muscle Wasting and Sarcopenia. A Review

Campins

Camps²,

Riera³

et al. 2016

Pharmacology

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Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and function. Reported prevalence of this geriatric syndrome, differs depending on the definition, the population and the method used to identify sarcopenia. The causes of sarcopenia are multifactorial, and can include genetic influence, immobility or disuse, endocrine factors, inflammation and nutritional deficiencies. These disorders involve an imbalance between anabolic and catabolic pathways that rules muscle mass. Many drugs taken regularly for common conditions may interact with some mechanisms that can alter the balance between protein synthesis and degradation. This may lead to a harmful or a beneficial effect on muscle mass and strength. Widely prescribed drugs could play an important role during the time of onset and development of sarcopenia. In this paper, we reviewed the current understanding of how can drugs contribute positively or negatively on sarcopenia and muscle wasting. We decided to focus this review on oral common drugs, which are usually prescribed in older adults, leaving aside other drugs as hormone therapy.

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Section: Vitamin Dmentioning

confidence: 99%

Oral Drugs Related with Muscle Wasting and Sarcopenia. A Review

Campins

Camps²,

Riera³

et al. 2016

Pharmacology

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“…Continuous variables were dichotomized based on the distribution of participants' scores; cut points were the worst-performing 10th centile. We have previously shown that the EMAS FI is linked with poorer sexual health , low levels of serum vitamin D (Tajar et al, 2012), and disruption in hormones of the hypothalamic-pituitary-testicular axis (Tajar et al, 2011).…”

Section: Frailtymentioning

confidence: 99%

The ability of three different models of frailty to predict all-cause mortality: Results from the European Male Aging Study (EMAS)

Ravindrarajah

Lee

Pye

et al. 2013

Archives of Gerontology and Geriatrics

121

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“…Our study controverts that paradigm by identifying a significant number of cases of hyperparathyroidism, which would not have been identified if the usual diagnostic guidelines were followed. Considering the growing understanding of the role that high levels of PTH have in the pathogenesis of sarcopenia, falls, and frailty [30,31]independently of vitamin D levels-this finding could have a significant impact on clinical practice by providing a strong rationale to include serum PTH when assessing patients at high risk of falls and fractures.…”

Section: Discussionmentioning

confidence: 99%

Yield and cost-effectiveness of laboratory testing to identify metabolic contributors to falls and fractures in older persons

et al. 2015

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The association of frailty with serum 25-hydroxyvitamin D and parathyroid hormone levels in older European men

Abstract: lower 25(OH)D and higher PTH levels were positively associated with frailty in older men. Prospective data would enable the temporal nature of this relationship to be explored further.

Cited by 76 publications

References 30 publications

Oral Drugs Related with Muscle Wasting and Sarcopenia. A Review

Oral Drugs Related with Muscle Wasting and Sarcopenia. A Review

The ability of three different models of frailty to predict all-cause mortality: Results from the European Male Aging Study (EMAS)

Yield and cost-effectiveness of laboratory testing to identify metabolic contributors to falls and fractures in older persons

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