The association of fetal and childhood growth with risk of schizophrenia. Cohort study of 720,000 Swedish men and women

Gunnell, David; Harrison, Glynn; Whitley, Elise; Lewis, Glyn; Tynelius, Per; Rasmussen, Finn

doi:10.1016/j.schres.2005.07.022

Cited by 58 publications

(78 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several other cohort studies using population-based data have recently been conducted but they have only addressed specific OCs, 3,4 such as the association between fetal growth measures and schizophrenia (in a cohort of Swedish male conscripts); instead of, the association between prenatal exposure to maternal hypertension/diuretic treatment and schizophrenia; and the association between prenatal exposure to analgesics and schizophrenia (both in a Danish cohort using national population-based register data). 5,6 Finally, one study 7 examined the association between maternal-fetal blood incompatibility and schizophrenia in a large Californiabased cohort.…”

Section: Obstetric Complicationsmentioning

confidence: 99%

Predicting Risk and the Emergence of Schizophrenia

Clarke

Kelleher

Clancy

et al. 2012

Psychiatric Clinics of North America

View full text Add to dashboard Cite

Section: Obstetric Complicationsmentioning

confidence: 99%

Predicting Risk and the Emergence of Schizophrenia

Clarke

Kelleher

Clancy

et al. 2012

Psychiatric Clinics of North America

View full text Add to dashboard Cite

“…The associations of fetal and childhood growth and body size in young adulthood with the risk of schizophrenia were studied in a Swedish cohort (study) including 719 476 singleton males and females, born in Sweden between 1973 and 1980 (13). These study subjects were alive and resident in Sweden at the age of 16 years.…”

Section: Study Populationsmentioning

confidence: 99%

“…Poor school performance and poor results in intelligence tests may also be the risk factors or perhaps more likely prodromal symptoms of schizophrenia becoming manifest later in life (11). As described in greater details later, low body mass index (BMI) (12,13) and short stature in adolescence (13) have recently been recognized as risk factors for schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Paternal age, size at birth, and size in young adulthood – risk factors for schizophrenia

Rasmussen

2006

eur j endocrinol

View full text Add to dashboard Cite

It is appropriate to consider schizophrenia a neurodevelopmental disorder with its pathogenesis going back to gestation and early childhood. Schizophrenia is a rare disease and large cohorts are needed to study its etiology. The aim of this paper is to review the results of recent Swedish record-linkage studies with a focus on: (i) measures of fetal and childhood growth in relation to schizophrenia in adulthood and (ii) paternal age in relation to schizophrenia. A record-linkage was created between national registers, including the Medical Birth Register, the Military Service Conscription Register, and the Inpatient Hospital Discharge Register. More than 700 000 subjects born between 1973 and 1980 were followed in these registers from birth to 31 December 2001/2002. The results showed no evidence of an association between birth weight and schizophrenia. An association of birth length with schizophrenia was observed, with short babies showing the highest risk. Short stature and low BMI in young adulthood were associated with increased risk. Short babies who became tall, or developed high BMI as adults, were not at increased risk. In fully adjusted analyses, the risk of schizophrenia was 4.62 (95% confidence interval : 2.28; 9.36) times higher in subjects whose fathers were R50 years old and at time of conception than in subjects whose fathers were 21-24 years old. Growth and development in fetal life and childhood are influencing the risk of schizophrenia in adulthood, but the underlying causal pathways are still unknown. De novo mutations in the germ cells of older fathers may play a causal role in the etiology of some cases of schizophrenia.European Journal of Endocrinology 155 S65-S69

show abstract

“…Vários estudos documentaram a associação entre restrição do crescimento fetal e o risco de desenvolver transtornos do comportamento, esquizofrenia e psicoses na adolescência ou na vida adulta 9,10,11,12 . O peso ao nascer, nesse sentido, é um indicador da saúde do recém-nascido, que reflete as condições da vida intrauterina.…”

Section: Introductionunclassified

Tamanho ao nascer e problemas de saúde mental aos 11 anos em uma coorte brasileira de nascimentos

et al. 2011

View full text Add to dashboard Cite

O objetivo foi avaliar a associação entre tamanho ao nascer e problemas de saúde mental aos 11 anos na Coorte de Nascimentos de Pelotas, Rio Grande do Sul, Brasil, de 1993. Foram pesados e medidos ao nascer 4.358 recém-nascidos. Avaliou-se problemas de saúde mental com o questionário de capacidades e dificuldades (Strengths and Difficulties Questionnaire - SDQ). A prevalência de problemas de saúde mental foi de 32% (IC95%: 31-33). Na análise ajustada, os 291 (6,7%) recém-nascidos com escorez de peso/idade e os 268 (6,2%) com índice de massa corporal (IMC)/idade < -2 DP tiveram, respectivamente, 27% (IC95%: 7-49) e 29% (IC95%: 10-51) maior risco de apresentar problemas de saúde mental aos 11 anos quando comparados com aqueles com escore normal. Os 102 (2,43%) recém-nascidos com escorez de IMC e os 279 (6,4%) com perímetro cefálico/idade > +2 DP tiveram, respectivamente, 34% (IC95%: 6-71) e 19% (IC95%: 1-40) maior risco de apresentar esses problemas se comparados com aqueles com escore normal. Os resultados sugerem que fatores ocorridos na gestação e refletidos nas medidas de tamanho ao nascer podem ocasionar problemas de saúde mental em etapas tardias.

show abstract

The association of fetal and childhood growth with risk of schizophrenia. Cohort study of 720,000 Swedish men and women

Cited by 58 publications

References 23 publications

Predicting Risk and the Emergence of Schizophrenia

Predicting Risk and the Emergence of Schizophrenia

Paternal age, size at birth, and size in young adulthood – risk factors for schizophrenia

Tamanho ao nascer e problemas de saúde mental aos 11 anos em uma coorte brasileira de nascimentos

Contact Info

Product

Resources

About