The Association of Estimated Whole Blood Viscosity with Hemodynamic Parameters and Prognosis in Patients with Heart Failure

Abstract

Aim: We aimed to investigate the association of estimated whole blood viscosity (WBV) with hemodynamic parameters and prognosis in patients with heart failure with reduced ejection fraction. Materials & methods: Total of 542 patients were included and followed-up for median 13 months. Results: The WBV parameters had negative relationship with right atrium pressure and positive correlation with cardiac index. The WBV parameters were found to be independent predictors of composite end point (CEP) and all-cause mortality. Every one cP increases of WBV(h) and WBV(l) were associated with 17 and 1% reductions of CEP. In Kaplan–Meier analysis, patients with low WBV quartiles were found to have significantly more CEP. Conclusion: Being an easily accessible and costless prognosticator, WBV seems to be a novel marker for determining prognosis and an emerging tool to individualize heart failure with reduced ejection fraction management.

Intraoperative changes in whole-blood viscosity in patients undergoing robot-assisted laparoscopic prostatectomy in the steep Trendelenburg position with pneumoperitoneum: a prospective nonrandomized observational cohort study

“…Notably, viscosity decreased after hydration therapy, but hyperviscosity recurred when hydration therapy was discontinued [11]. Our study population showed a more stable clinical condition before surgery, as represented by ASA physical status I or II, compared to the patients in previous studies [10,11,13,20,30]. During RALP surgery, we encountered no hemodynamic instability that required aggressive fluid or blood product transfusion therapy.…”

“…Many clinical studies have suggested that elevated WBV is associated with the development of cardiovascular and cerebrovascular diseases [10,11,13,30]. In patients with mitral annular calcification, higher WBV was predictive of pathologic mitral annulus.…”

“…This viscosity is also associated with features of blood components, such as deformability, aggregation, and concentration of red blood cells and other proteins [6,8,9]. Because increased WBV may cause greater oscillation of shear stress in relation to endothelial injury, close association of WBV with the development of cardio-and/or cerebrovascular diseases has been reported in clinical settings [10][11][12][13][14]. Additionally, various risk factors, such as obesity, aging, and comorbidity, seem to contribute to increases in WBV [6,9,[15][16][17][18].…”

Tam Kan Akışkanlığı ile Alt Ekstremite Periferik Arter Hastalığı Şiddeti Arasındaki İlişki

“…In their study De Simone et al evaluated WBV with a simple, costless equation using total protein and HCT levels at different shear rates [8]. The prognostic value of estimated WBV calculated by this formula has been demonstrated in many studies for cardiovascular diseases [11][12][13][14][15]. In our study, we also preferred to use this formula to evaluate WBV.…”

Evaluating of Red Blood Cell Distribution Width, Comorbidities and Electrocardiographic Ratios as Predictors of Prognosis in Patients with Pulmonary Hypertension

“…Notably, erythrocytosis may result in symptoms of hyperviscosity in patients with heart failure [ 38 ], but these conditions rarely appear until HTO is >65% and are related to its progressive increase and not to its elevated level per se. On the other hand, it is possible that compensated erythrocytosis manifests in these patients when HTO values (even those greater than 70%) remain stable for a long time, while decompensated erythrocytosis is generated when these values are not stable or increase progressively [ 39 , 40 ].…”