The association of ESBL-producing Enterobacteriaceae (ESBL-E) carriage in humans with pigs

Denkel, Luisa A.; Gastmeier, Petra; Leistner, Rasmus

doi:10.1017/s095026881500240x

Cited by 5 publications

(6 citation statements)

References 7 publications

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“…In their letter, Denkel et al [1] report on data from the German National Reference Center for the Surveillance of Nosocomial Infections (KISS) in hospitals, which indicate that the federal state of North Rhine-Westphalia (NRW) was among the risk factors for a significantly increased proportion of nosocomial infection due to ESBL-E (odds ratio 1•41) [9]. Denkel et al discuss that 'this observation suggests a relationship between the production farming of pigs and the emergence of ESBL-E infections in the same regions', because the state of NRW also comprises regions with a high density of livestock production.…”

Section: To the Editormentioning

confidence: 96%

“…In their recent letter, Denkel et al . [1] pointed out that contact with livestock animals can indeed be a risk factor for the acquisition of colonization with extended-spectrum β -lactamase-producing Enterobacteriaceae (ESBL-E) among humans. This has been demonstrated for pig farmers and poultry farmers, for whom ESBL-E carriage rates reached 6–33% [2, 3], which exceeds carriage rates expected for the general population [4, 5].…”

mentioning

confidence: 99%

“…In their letter, Denkel et al . [1] report on data from the German National Reference Center for the Surveillance of Nosocomial Infections (KISS) in hospitals, which indicate that the federal state of North Rhine-Westphalia (NRW) was among the risk factors for a significantly increased proportion of nosocomial infection due to ESBL-E (odds ratio 1·41) [9]. Denkel et al .…”

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confidence: 99%

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The association of ESBL-producing Enterobacteriaceae (ESBL-E) carriage in humans with pigs – a reply

et al. 2015

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Section: To the Editormentioning

confidence: 96%

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confidence: 99%

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confidence: 99%

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The association of ESBL-producing Enterobacteriaceae (ESBL-E) carriage in humans with pigs – a reply

et al. 2015

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“…and macrolide resistant Campylobacter spp. (Aidara-Kane et al, 2013), while there is strong evidence that they are involved in other infectious diseases caused by extended spectrum beta-lactamase (ESBL) producing-E. coli (Dahms et al, 2015;Dohmen et al, 2015;Denkel et al, 2016) and vancomycin resistant Enterococcus spp. (VRE) in humans (Swartz, 2002;Newell et al, 2010;Aidara-Kane et al, 2013;WHO, 2015c).…”

Section: Public Health Implicationsmentioning

confidence: 99%

Antimicrobial Resistance in the Farm-To-Plate Continuum: More Than a Food Safety Issue

Founou¹,

Founou²,

Essack³

2020

Preprint

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Antimicrobial resistance (AMR) threatens to reverse the essential benefits of antibiotics not only in humans, where decades of advancements in healthcare outcomes are endangered but also in the food production industry. The emergence of AMR in the pre- and post-harvest systems presents a serious risk of contamination or infection directly by antibiotic-resistant bacteria (ARB) and genes (ARGs) for farmers, agricultural practitioners, abattoir workers, food handlers and their associated contacts as well as consumers at the end of the food chain. Any breach in the food safety barrier leading to the emergence and spread of ARB and ARGs has severe multi-sectorial implications and threatens to reverse decades of human and animal health improvements globally. As the world moves towards Sustainable Development Goals (SDGs), food safety is a critical element to improve and strengthen global health, security and ensure sustainable development. This paper presents the challenge of AMR through the lens of food safety, by highlighting its multi-sectoral and multi-dimensional implications not only the SDG on food safety but also on food security, public health, animal health and welfare, the environment and climate and socio-economic development.

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“…Several studies proved a link between the use of 3 rd and 4 th generation cephalosporins and selection of ESBL-producing E. coli in poultry (Dutil et al 2010), cows (Tragesser et al 2006;Dolejska et al 2011) and pigs (Jørgensen et al 2007;Lutz et al 2011;Agersø et al 2012;Andersen et al 2015). The occurrence of ESBL-producing commensal E. coli in swine is alarming due to the potential risk of transfer of antibiotic resistance determinants to human microbiome via the food chain (Denkel et al 2016). Increasing prevalence of ESBL-producing E. coli led to a voluntary ban or significant reduction of cephalosporin use in pig production in some European countries (EMA 2015).…”

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confidence: 99%

Occurrence and faecal shedding of extended-spectrum beta-lactamase-producing Escherichia coli in sows and their offspring

et al. 2020

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The aim of the present study was to monitor the presence of extended-spectrum beta-lactamase (ESBL) producing E. coli on farm A with the history of previous use of ceftiofur in suckling pigletsand to analyse the risk factors of selection and dissemination of ESBL producers in the production herd. In the year of 2014, a total of 411 samples (rectal swabs or faeces)from pigs of various age categories (sows, gilts and suckling piglets) were collected. The sampling was performed more than 24 months after the ban of ceftiofur on the farm.The sows and gilts were sampled repeatedly before and after farrowing. All collected samples were directly cultivated on MacConkey agar (MCA) containing cefotaxime (2 mg/l) and obtained sub-cultures were tested for ESBL production by double disc synergy test. According to our results, all gilts were negative for ESBL-producing E. coli in the introduction period, however, the excretion of ESBL-producing E. coli was observed before and after delivery. Most of the new-born piglets from positive sows and gilts shed ESBL-producing E. coli early after birth. All tested ESBL-producing isolates were resistant to multiple antimicrobials, suggesting that antibiotics from other groups used for therapy co-select for ESBL producers in pigs on the studied farm. Intestinal colonization of lactating sows and their offspring as well as survival of ESBL-producing E. coli in the farm environment should be recognised as important risk factors of circulation and long-time persistence of ESBL producers in the herd.

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The association of ESBL-producing Enterobacteriaceae (ESBL-E) carriage in humans with pigs

Cited by 5 publications

References 7 publications

The association of ESBL-producing Enterobacteriaceae (ESBL-E) carriage in humans with pigs – a reply

The association of ESBL-producing Enterobacteriaceae (ESBL-E) carriage in humans with pigs – a reply

Antimicrobial Resistance in the Farm-To-Plate Continuum: More Than a Food Safety Issue

Occurrence and faecal shedding of extended-spectrum beta-lactamase-producing Escherichia coli in sows and their offspring

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