The association of endothelial nitric oxide synthase gene G894T polymorphism and serum nitric oxide concentration with microalbuminuria in patients with gestational diabetes

Atay, Ahmet Engin; Akbas, Halit; Tümer, Cemıl; Şakar, Mehmet; Esen, Bennur; Incebiyik, Adnan; Şimşek, Selda; Şit, Dede

doi:10.5414/cn108138

Cited by 18 publications

(14 citation statements)

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“…All of these correlations were positive with ADMA and negative with NO. Similarly Atay et al (37) found NO, glucose, creatinine, and microalbuminuria were significantly different between GDM patients and control subjects and in another study, Atay et al (38) found normotensive patients with GDM had significantly reduced NO levels. Moreover, Gumus et al (39) found the insulin and ADMA, and HOMA-IR levels were significantly higher in patients with a history of GDM and Xia et al (40) detected significantly higher serum ADMA and CRP with increased carotid intima-media thickness (CIMT) in women with previous GDM than healthy controls with positive correlation between ADMA and CRP and CIMT with ADMA being a significant predictor for elevated CIMT in subjects with previous GDM.…”

Section: Discussion:-mentioning

confidence: 84%

Reciprocal Relationship Between Insulin Resistance and Disturbed Adma/No Axis in Gestational Diabetes Mellitus.

MD¹,

MD²,

MD³

2018

IJAR

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Objectives: To estimate serum nitric oxide (NO) and asymmetric dimethylarginine (ADMA) levels in pregnant women and correlate it with severity of gestational diabetes mellitus (GDM) judged by Oral Glucose Tolerance Test (OGTT). Patients & Methods: 225 pregnant women gave fasting blood samples to estimate baseline blood glucose (BG), and serum insulin, NO and ADMA, and to undergo OGTT. Insulin resistance (IR) was indicated by HOMA-IR score >2. At 24 th week, blood sample were re-evaluated using OGTT and women were categorized in Study (GDM) and Control (free of GDM) group. Results: At 24 th week, HOMA-IR scores were significantly higher than baseline scores and in study versus control women. Baseline serum ADMA levels were significantly higher, while serum NO levels were significantly lower in study versus control women and correlated with body mass index (BMI), GDM, BG and HOMA-IR score of all women. Serum ADMA and NO showed significant correlation with extent of serum insulin change, but low serum NO is significant predictor for development and severity of IR. Conclusion: IR induces endothelial dysfunction manifested as low serum NO and high serum ADMA. Baseline serum NO could predict the extent of serum insulin change.

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Section: Discussion:-mentioning

confidence: 84%

Reciprocal Relationship Between Insulin Resistance and Disturbed Adma/No Axis in Gestational Diabetes Mellitus.

MD¹,

MD²,

MD³

2018

IJAR

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“…Three comparisons (Motawi et al ,10 Atay e t al 19 and Sakar et al 21) were identified as the main contributors to the heterogeneity by using Galbraith plot. The MD value and 95% CI (MD −0.13 μmol/L, 95% CI −0.22 to −0.04 μmol/L, p heterogeneity =0.89, p MD <0.001) did not change substantially after excluding these outlier comparisons (table 2).…”

Section: Resultsmentioning

confidence: 99%

Associations of theNOS3rs1799983 polymorphism with circulating nitric oxide and lipid levels: a systematic review and meta-analysis

Wang

Jia

et al. 2019

Postgraduate Medical Journal

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BackgroundCirculating nitric oxide (NO) and lipid levels are closely associated with coronary artery disease (CAD). It is unclear whether the rs1799983 polymorphism in endothelial nitric oxide synthase (NOS3) gene is associated with plasma levels of NO and lipids. This systematic review and meta-analysis (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) aimed to clarify the relationships between the rs1799983 polymorphism and plasma levels of NO and lipids.MethodsSixteen studies (2702 subjects) and 59 studies (14 148 subjects) were identified for the association analyses for NO and lipids, respectively. Mean difference (MD) and 95% CI were used to estimate the effects of the rs1799983 polymorphism on plasma NO and lipid levels. The primary outcome variable was NO, and the secondary outcomes included triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C).ResultsCarriers of the T allele had lower levels of NO (MD −0.27 μmol/L, 95% CI −0.42 to −0.12 μmol/L, p<0.001) and HDL-C (MD −0.07 mmol/L, 95% CI −0.14 to −0.00 mmol/L, p=0.04), and higher levels of TC (MD 0.13 mmol/L, 95% CI 0.06 to 0.20 mmol/L, p<0.001) and LDL-C (MD 0.14 mmol/L, 95% CI 0.05 to 0.22 mmol/L, p=0.002) than the non-carriers. Triglyceride levels were comparable between the genotypes.ConclusionThe association between the NOS3 rs1799983 polymorphism and CAD may be partly mediated by abnormal NO and lipid levels caused by the T allele.

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“…NOS3 gene polymorphisms were also investigated in pregnant women with GDM. Atay et al . investigated the association between the NOS3 gene rs1799983 polymorphism and serum nitric oxide levels and microalbuminuria in women with GDM and healthy pregnancies.…”

Section: Discussionmentioning

confidence: 99%

“…33 NOS3 gene polymorphisms were also investigated in pregnant women with GDM. Atay et al 34 investigated the association between the NOS3 gene rs1799983 poly- Cycloogenase 2 is the enzyme responsible for the synthesis of prostaglandins. It was shown that this enzyme may be involved in the pathogenesis of diabetes type 2 and GDM.…”

Section: Discussionmentioning

confidence: 99%

COX2 and NOS3 gene polymorphisms in women with gestational diabetes

Tarnowski

Tkacz

Dziedziejko

et al. 2017

The Journal of Gene Medicine

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The association of endothelial nitric oxide synthase gene G894T polymorphism and serum nitric oxide concentration with microalbuminuria in patients with gestational diabetes

Cited by 18 publications

References 0 publications

Reciprocal Relationship Between Insulin Resistance and Disturbed Adma/No Axis in Gestational Diabetes Mellitus.

Reciprocal Relationship Between Insulin Resistance and Disturbed Adma/No Axis in Gestational Diabetes Mellitus.

Associations of theNOS3rs1799983 polymorphism with circulating nitric oxide and lipid levels: a systematic review and meta-analysis

COX2 and NOS3 gene polymorphisms in women with gestational diabetes

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