The association of elevated plasma cortisol and early atherosclerosis as demonstrated by coronary angiography

Troxler, Raymond G.; Sprague, Eugene A.; Albanese, Richard A.; Fuchs, Robert; Thompson, Amanda

doi:10.1016/0021-9150(77)90098-3

Cited by 212 publications

(87 citation statements)

References 36 publications

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“…Elevated cortisol levels have been associated not only with depression but also coronary disease (Koertge et al 2002;Troxler et al 1977); we did not observe a cross-sectional association between cortisol and worse cardiac disease severity, however. One potential reason for the differences between our study and those demonstrating a link between cortisol and coronary atherosclerosis is that we did not use angiographic or carotid ultrasound measurements to determine level of atherosclerosis.…”

Section: Discussioncontrasting

confidence: 85%

Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: The Heart and Soul Study

Otte

Marmar

Pipkin

et al. 2004

Biological Psychiatry

117

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Background-In patients with coronary heart disease (CHD), depression leads to worse cardiovascular outcomes. Depression has been associated with increased cortisol in medically healthy patients, suggesting that cortisol may act as a mediator in the pathway between depression and cardiovascular events. However, it is not known whether depression is associated with elevated cortisol levels in patients with CHD.

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Section: Discussioncontrasting

confidence: 85%

Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: The Heart and Soul Study

Otte

Marmar

Pipkin

et al. 2004

Biological Psychiatry

117

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“…The results of our correlation analysis are in accordance with findings of Akaza et al [15] who showed a significant negative correlation between percentage changes in brachial artery diameter during flow mediated dilatation and morning cortisol levels in patients of CS. Although morning serum cortisol level is not considered to be a disease marker in CS due to its inherent inter-individual variations independent of the disease status, our findings indicate the probable pathophysiologic role excess cortisol levels can play in the causation of vascular endothelial dysfunction as already been shown by previous studies [9][10][11].…”

Section: Discussionsupporting

confidence: 54%

“…High plasma cortisol levels have been linked to the presence and severity of coronary atherosclerosis in patients who presented with clinical and electrocardiographic evidence of coronary artery disease [9]. Recently, a direct causative role of cortisol in the induction of vascular endothelial dysfunction has been suggested by studies conducted in patients treated with exogenous glucocorticoids [10] and normal human subjects administered with short term oral hydrocortisone All India Institute of Medical Sciences, New Delhi.…”

mentioning

confidence: 99%

Impaired endothelium mediated vascular reactivity in endogenous Cushing's syndrome

et al. 2011

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“…The decrease in cortical observed during the control session corresponds to established circadian patterns (25,26). This normal circadian variation in cortisol was offset when subjects were presented with challenging tasks.…”

Section: Discussionmentioning

confidence: 79%

Cardiovascular and neuroendocrine responses to extended laboratory challenge.

McCann

Carter

Vaughan

et al. 1993

Psychosomatic Medicine

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The purpose of this study was to examine the effects of a 2-hour laboratory challenge on heart rate, blood pressure, catecholamines, and cortisol; and investigate the contribution of the physical act of speaking on both neuroendocrine and cardiovascular measures. Using a within-subjects design, 14 subjects were tested individually during two separate laboratory sessions. During one session, subjects engaged in two cognitively demanding tasks for 2 hours. During the other session, subjects executed the verbal demands of the tasks for 2 hours, but cognitive demands were absent. During both sessions, blood pressure and heart rate were measured and arterialized blood samples were obtained for the measurement of epinephrine, norepinephrine, and cortisol. Subjects demonstrated significantly greater increases in systolic blood pressure, diastolic blood pressure, heart rate, epinephrine, and cortisol during the cognitively challenging session than during the control session. It is concluded that sustained elevations in cardiovascular and neuroendocrine measures can be achieved in the laboratory, and that the effects of such tasks cannot be attributed solely to the physical demands of speaking. Implications for the measurement of circulating catecholamines and cortisol during laboratory studies are discussed.

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The association of elevated plasma cortisol and early atherosclerosis as demonstrated by coronary angiography

Cited by 212 publications

References 36 publications

Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: The Heart and Soul Study

Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: The Heart and Soul Study

Impaired endothelium mediated vascular reactivity in endogenous Cushing's syndrome

Cardiovascular and neuroendocrine responses to extended laboratory challenge.

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