The association of dyslipidemia with erythrocyte aggregation

Gyawali, Prajwal; Richards, Ross S.; Bwititi, Phillip; Nwose, Ezekiel Uba

doi:10.2217/clp.15.3

Cited by 9 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Knowing that hemoglobin affinity for oxygen is not altered during SARS-CoV-2 infection [48] , this decrease in erythrogram parameters may explain in part the need for artificial ventilation experienced by COVID-19 ICU individuals [28] . Considering that, dyslipidemia has been associated with erythrocyte aggregation which may lead to a decreased life span of the cell [49] , our data showing a reduction in erythrogram parameters in severe COVID-19 patients may be related to the reduction in HDL levels, also observed in non-comorbid patients.…”

Section: Discussionsupporting

confidence: 50%

COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study

Kimura

Sant’Anna

Andrade

et al. 2021

Blood Cells, Molecules, and Diseases

View full text Add to dashboard Cite

Patients with COVID-19 can be asymptomatic or present mild to severe symptoms, leading to respiratory and cardiovascular complications and death. Type 2 diabetes mellitus (T2DM) and obesity are considered risk factors for COVID-19 poor prognosis. In parallel, COVID-19 severe patients exhibit dyslipidemia and alterations in neutrophil to lymphocyte ratio (NLR) associated with disease severity and mortality. To investigate whether such alterations are caused by the infection or results from preexisting comorbidities, this work analyzed dyslipidemia and the hemogram profile of COVID-19 patients according to the severity and compared with patients without T2DM or obesity comorbidities. Dyslipidemia, with a marked decrease in HDL levels, and increased NLR accompanied the disease severity, even in non-T2DM and non-obese patients, indicating that COVID-19 causes the observed alterations. Because decreased hemoglobin is involved in COVID-19 severity, and hemoglobin concentration is associated with metabolic diseases, the erythrogram of patients was also evaluated. We verified a drop in hemoglobin and erythrocyte number in severe patients, independently of T2DM and obesity, which may explain in part the need for artificial ventilation in severe cases. Thus, the control of such parameters (especially HDL levels, NLR, and hemoglobin concentration) could be a good strategy to prevent COVID-19 complications and death.

show abstract

Section: Discussionsupporting

confidence: 50%

COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study

Kimura

Sant’Anna

Andrade

et al. 2021

Blood Cells, Molecules, and Diseases

View full text Add to dashboard Cite

show abstract

“…Park et al (2018) reported that CSS was strongly correlated with acute myocardial infarction in patients with T2DM. CSS has also been found to correlate highly with hyperlipidemia (Gyawali et al, 2015a), chronic inflammatory indexes, and oxidative stress (Gyawali et al, 2015b). Furthermore, Gyawali et al (2014) reported that CSS alone could be used to diagnose metabolic syndrome (MetS) with higher sensitivity and specificity than other conventional indexes such as the ankle brachial pressure index.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Potential Diagnostic Hemorheological Indexes for Chronic Kidney Disease in Patients With Type 2 Diabetes

Lee

et al. 2019

Front. Physiol.

View full text Add to dashboard Cite

Many studies have demonstrated that an alteration in hemorheological properties is closely correlated with diabetic microcirculatory diseases. However, most of these studies have been limited to animal studies or used a small number of clinical samples, due to a lack of effective point-of-care (POC) devices to measure such properties within clinical environments. Owing to recent developments in microfluidic technology, several hemorheological POC devices have been designed that allow for the possibility of conducting extensive clinical studies using hemorheological measurements. Here, we reviewed recent clinical studies of diabetic kidney disease (DKD) associated with hemorheological parameters. We found that RBC deformability alone did not show a significant difference according to the degree of DKD, whereas critical shear stress (CSS) was found to be closely related to the ratio of albumin to creatinine and glomerular filtration rate. We also reviewed studies that alteration of hemorheological properties are associated with the development of DKD, which showed that CSS could be considered as a potential index to diagnose other diabetic complications as well as DKD.

show abstract

“…Значение морфофункциональных изменений эритроцитов при МС менее изучено, на сегодняшний день в мировой литературе нами не найдено исследований, оцени-вающих состояние ЭЗЭ при МС. В единичных работах показано снижение электрического потенциала эрит-роцитов у больных с АГ, сахарным диабетом и дисли-пидемией [9][10][11][12].…”

Section: Discussionunclassified

Relation of Disturbances in the Erythrocytes Electrical Activity With Dyslipidemia in the Metabolic Syndrome

Подзолков¹,

Королева²,

Брагина³

et al. 2018

Racionalʹnaâ farmakoterapiâ v kardiologii

View full text Add to dashboard Cite

Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет) Россия, 119991, Москва, ул. Трубецкая, 8 стр. 2 Цель. Исследование электрического заряда эритроцитов (ЭЗЭ) у больных метаболическим синдромом (МС). Материал и методы. Обследовано 112 больных МС (средний возраст 61,4±7,2 лет, средняя продолжительность МС 8,7±5,2 лет). Группу контроля (25 человек) составили относительно здоровые люди сходного возраста. Уровень ЭЗЭ определяли методом адсорбции положи-тельного катионного красителя (катионный синий О) на поверхности плазматической мембраны эритроцитов до полной нейтрализации их отрицательного заряда с последующей фотометрией раствора и расчета числа зарядов на клеточной поверхности эритроцитов. Результаты исследования обрабатывались с помощью программы Statistica 10.0. Результаты. В основной группе больных МС артериальная гипертензия выявлена у 73%, гипергликемия -у 39%, сахарный диабет -у 36%, дислипидемия -у 80%. Величина ЭЗЭ у больных МС (1,59±0,05×10 7 ) была статистически значимо ниже, чем в группе контроля (1,65±0,03×10 7 ; р<0,05). При длительности МС более 5 лет ЭЗЭ была статистически значимо ниже по сравнению с группой контроля (р<0,05). У больных с ожирением II-III степени, а также при дислипидеми показатели ЭЗЭ были статистически значимо ниже, чем в конт-рольной группе(р<0,05). У больных с МС была выявлена статистически значимая отрицательная корреляция между ЭЗЭ и уровнями общего холестерина (r=-0,51; p<0,05) и триглицеридов (r=-0,46; p<0,05). Заключение. У больных МС с увеличением длительности МС, степени ожирения и нарастания нарушений липидного обмена отмечаются статистически значимо более низкие значения ЭЗЭ.Ключевые слова: метаболический синдром, электрический заряд эритроцитов, ожирение, дислипидемия, микроциркуляция. Aim. To study the erythrocyte electric charge (EEC) in patients with metabolic syndrome (MS). Material and methods. 112 patients (mean age 61.4±7.2 years) with MS (average duration of MS 8.7±5.2 years) were examined. Control group consisted of healthy volunteers (n=25) of similar age. The level of EEC was detected by the method of adsorption of a positive cationic dye (cationic blue O) on the surface of the erythrocyte plasma membrane up to the complete neutralization of their negative charge, followed by photometry of the solution and calculation of the number of charges on the erythrocyte cell surface. The results of the study were processed by Statistica 10.0 software. Results. Hypertension was found in 73% of patients with MS, hyperglycemia -in 39%, diabetes -in 36%, dyslipidemia -in 80% of patients. The EEC in MS patients (1.59±0.05×10 7 ) was lower than this in the control group (1.65±0.03×10 7 ; p<0.05). With MS duration more than 5 years, the EEC was significantly lower in comparison with control group (p<0.05). In patients with obesity II-III degrees as well as dyslipidemia the EEC values were significantly lower vs control group (p<0.05). In patients with MS, a significant negative correlation of EEC with total cholesterol...

show abstract

The association of dyslipidemia with erythrocyte aggregation

Cited by 9 publications

References 27 publications

COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study

COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study

Potential Diagnostic Hemorheological Indexes for Chronic Kidney Disease in Patients With Type 2 Diabetes

Relation of Disturbances in the Erythrocytes Electrical Activity With Dyslipidemia in the Metabolic Syndrome

Contact Info

Product

Resources

About