The association of dietary inflammatory index with urinary risk factors of kidney stones formation in men with nephrolithiasis

Abstract

Objective: Inflammation plays a leading role in the pathogenesis of nephrolithiasis. The association of the dietary inflammatory index (DII) with urinary lithogenic factors is unclear. This study aimed to evaluate the relation of DII to urinary risk factors of kidney stones formation.Results: Of 264 participants, 61.4% (n= 162), 72% (n=190), 74.6% (n=197), 68.6% (n=181), and 80.3% (n=212) had hyperoxaluria, hypercreatininuria, hypercalciuria, hyperuricosuria, hypocitraturia, respectively. There was a significant increasing trajectory in urinary calcium, uric acid, and creatinine as well as a decreasing trend in urinary citrate across tertiles of DII score (all P=≤0.001). After multivariate adjustment for energy intake, age, physical activity and body mass index, high DII scores were associated with elevated odds of having hypercreatininuria (OR=2.80, 95%CI: 1.10-7.12, Ptrend=0.04), hypercalciuria (OR=7.44, 95%CI: 2.62-21.14, Ptrend≤0.001), hyperuricosuria (OR=2.22, 95%CI: 1.001-4.95, Ptrend=0.05), and hypocitraturia (OR=5.84, 95%CI: 2.14-15.91, Ptrend≤0.001). No association was identified between DII and hyperoxaluria.

Dietary Inflammatory Index in relation to Type 2 Diabetes: A Meta-Analysis

“…For instance, dietary flavonoid intake has been inversely associated with inflammation [11], whereas saturated fatty acids have shown a positive association [12]. However, studying whole dietary patterns/indices may be better in evaluating the inflammatory effect of diet because such patterns/indices can capture the interaction of multiple nutrients or foods to reflect the complexity of a diet [13]. Dietary diversity index, also known as potential inflammatory of diet, is a literaturederived, population-based dietary index developed by Shivappa et al [14].…”

Rising prevalence of renal calculi

“…Metabolic disorders such as diabetes and the metabolic syndrome result in hypercalciuria, hyperoxaluria, hyperuricosuria, and hypocitraturia (see Health disorders associated with renal calculi ). The presence of such metabolic alterations increases the risk of renal calculi formation 3,8…”