The association of cytokine genes polymorphisms and susceptibility to aplastic anemia in Egyptian patients

Abstract

IFN-γ +874 A/T gene polymorphism is associated with the etiology of AA in Egyptian patients.

Prognostic value of TNF-a-308 and IFN-g-874 single nucleotide polymorphisms and their plasma levels in patients with aplastic anemia

“…. TNF-α-308 positively correlated with AA in our population; this result is not in agreement with earlier findings available on the subject [22]. This inconsistency might be due to the smaller sample size, selection criteria, ethnicity, and geographical variation of study subjects.…”

The relationship between interferon-gamma (INF-γ) single nucleotide polymorphism +874(T/A) and occurrence risk of aplastic anemia: a meta-analysis

“…No additional studies were found by manual search. Finally, five articles were included in this meta-analysis [10][11][12][13]16].…”

“…All these studies detected the polymorphisms of IFN-γ by PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism), PCR-SSP (polymerase chain reaction-sequence-specific primer) or ARMS-PCR (amplification refractory mutation system-polymerase chain reaction), except one study did not describe the detection method [13]. The polymorphisms of IFN-γ of the controls in each included study met the Hardy-Weinberg equilibrium, except El Mahgoub IR 2014 [11] and Zayed RA 2015 [16]. In addition, based on the NOS scores, no low-quality studies were included in this meta-analysis (Table 1).…”

Interlukin‐27 rs153109 polymorphism confers the susceptibility and prognosis of aplastic anemia in Chinese population

“…gene polymorphisms were explored to estimate the correlation with genetic predisposition to aplastic anemia; nonetheless, few explicit contributors have been identified. [25][26][27] Among the polymorphic sites identified, HLA-DPB1, IFNγ + 874 A/T, and TNFα-308 G/A were proved to contribute to the susceptibility of aplastic anemia. 25,26 The IL-27 gene, located in chromosome 16p11, plays important role in regulating polarization of T cells.…”