The Association of Crohn’s Disease, Celiac Disease and Selective Ig A Deficiency

Abstract

Concomitant occurrence of celiac disease (CeD) and Crohn's disease (CD) is rare and has been reported in several case reports and series. We report a case of a 63-year-old man with proximal CD, CeD and selective immunoglobulin (Ig) A deficiency (SIgAD). The patient was admitted in our Clinic for evaluation of epigastric pain, nausea, vomiting and weight loss (up to 7 kg) appeared in the last 3 months. The imaging findings from abdominal ultrasound and CT enterography raised suspicion of a lymphoproliferative disease of the jejunum. To exclude the development of lymphoma based on long standing untreated atypical CeD, upper endoscopy with biopsies and serological tests were conducted, showing and subtotal villous atrophy and elevated levels of IgG tissue transglutaminase tTG. Histopathology documented CD (A3,L4,B2 according to Montreal's classification).

Trends in Hospitalizations for Celiac Disease in the United States

“…In severe cases, CD can lead to digestive cancers which can be fatal [14]. There is increasing evidence that patients with celiac disease are at a higher risk of having additional autoimmune diseases such as Hashimoto's thyroiditis, Grave's disease, type 1 diabetes mellitus (T1DM), inflammatory bowel disease (IBD) and Crohn's disease [15,16,17,18]. There is currently no cure for CD.…”