The association of comorbidity with Parkinson's disease-related hospitalizations

Hommel, Adrianus L.A.J.; Krijthe, Jesse H.; Darweesh, Sirwan K.L.; Bloem, Bastiaan R.

doi:10.1016/j.parkreldis.2022.10.012

Cited by 14 publications

(11 citation statements)

References 36 publications

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“…There are, however, indications for a significantly higher risk for people with respiratory diseases (e.g., chronic obstructive pulmonary disease (COPD)) [28] or obstructive sleep apnea [29]) to develop PD. In addition, people with PD and COPD comorbidities are at greater risk for PDrelated hospitalization [30], potentially indicating a worse disease progression in this subpopulation. Similarly, stroke and PD appear to both increase the risk of each other, with a pooled odds ratio of PD postmortem brains exhibiting stroke pathology amounting to 1.86, as assessed by a recent meta-analysis [31].…”

Section: Impaired Systemic Oxygen-sensing and Ventilatory Dysfunctionmentioning

confidence: 99%

Hypoxia Sensing and Responses in Parkinson’s Disease

Burtscher,

Duderstadt,

Gatterer

et al. 2024

IJMS

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Parkinson’s disease (PD) is associated with various deficits in sensing and responding to reductions in oxygen availability (hypoxia). Here we summarize the evidence pointing to a central role of hypoxia in PD, discuss the relation of hypoxia and oxygen dependence with pathological hallmarks of PD, including mitochondrial dysfunction, dopaminergic vulnerability, and alpha-synuclein-related pathology, and highlight the link with cellular and systemic oxygen sensing. We describe cases suggesting that hypoxia may trigger Parkinsonian symptoms but also emphasize that the endogenous systems that protect from hypoxia can be harnessed to protect from PD. Finally, we provide examples of preclinical and clinical research substantiating this potential.

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Section: Impaired Systemic Oxygen-sensing and Ventilatory Dysfunctionmentioning

confidence: 99%

Hypoxia Sensing and Responses in Parkinson’s Disease

Burtscher,

Duderstadt,

Gatterer

et al. 2024

IJMS

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“…[5][6][7] In addition, people with PD have significant comorbidities, and comorbid illnesses are related to an increased risk of hospitalization. [8,9] Although PD progression is not abrupt, PD symptoms can be more severe temporarily when patients are ill. Infections, metabolic changes, exposure to anesthesia, changes in medication regimen or new medication changes are some common factors that may worsen PD symptoms during hospitalization.…”

Section: Why Do We Care?mentioning

confidence: 99%

Inpatient Parkinson’s Care: Challenges and Special Considerations

Yu¹

2023

JMUST

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“…Stroke and Parkinson disease (PD) are common problems in the aged population, and the coexistence of these disorders can lead to particularly unfavorable outcomes [2,3]. Previous studies have reported that PD patients with a history of stroke have increased risk of hospitalization [4,5], and even a silent vascular burden can affect the motor and nonmotor symptoms of PD patients [6]. Therefore, the relationship between PD and stroke could be clinically important.…”

Section: Introductionmentioning

confidence: 99%

Risk of Parkinson disease in stroke patients: A nationwide cohort study in South Korea

Choi,

Ahn,

Chang

et al. 2024

Euro J of Neurology

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Background and purposePrevious studies have examined the risk of stroke in patients with Parkinson disease (PD), but the incidence of PD onset among stroke patients and its risk according to severity of poststroke disabilities have scarcely been investigated. This study aims to determine whether the risk of PD is increased among stroke patients using a retrospective cohort with a large population‐based database.MethodsWe used data collected by the Korean National Health Insurance Service from 2010 to 2018 and examined 307,361 stroke patients and 380,917 sex‐ and age‐matched individuals without stroke to uncover the incidence of PD. Cox proportional hazards regression was used to calculate the hazard ratio (HR) and 95% confidence interval (CI), and the risk of PD was compared according to presence and severity of disability.ResultsDuring 4.31 years of follow‐up, stroke patients had a 1.67 times higher risk of PD compared to individuals without stroke (adjusted HR = 1.67, 95% CI = 1.57–1.78). The risk of PD was greater among stroke patients with disabilities than among those without disabilities, even after adjustment for multiple covariates (adjusted HR = 1.72, 95% CI = 1.55–1.91; and adjusted HR = 1.66, 95% CI = 1.56–1.77, respectively).ConclusionsOur study demonstrated an increased risk of PD among stroke patients. Health professionals need to pay careful attention to detecting movement disorders as clues for diagnosing PD.

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The association of comorbidity with Parkinson's disease-related hospitalizations

Cited by 14 publications

References 36 publications

Hypoxia Sensing and Responses in Parkinson’s Disease

Hypoxia Sensing and Responses in Parkinson’s Disease

Inpatient Parkinson’s Care: Challenges and Special Considerations

Risk of Parkinson disease in stroke patients: A nationwide cohort study in South Korea

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